DRSC/TRiP Functional Genomics Resources

powered by:
logo

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits


Protein Alignment ASH1L and lin-59

DIOPT Version :10

Sequence 1:NP_001353106.1 Gene:ASH1L / 55870 HGNCID:19088 Length:2969 Species:Homo sapiens
Sequence 2:NP_491206.1 Gene:lin-59 / 266825 WormBaseID:WBGene00003040 Length:1312 Species:Caenorhabditis elegans


Alignment Length:1448 Identity:322/1448 - (22%)
Similarity:501/1448 - (34%) Gaps:472/1448 - (32%)


- Green bases have known domain annotations that are detailed below.


Human  1544 SPSKSLINREEQWVHRE------PSESSPLALGLQTPLQIDCSESSPSLSLGGFTPNSEPASSDE 1602
            |||.:::|..:...|.:      |::.:.:.|........||.: .|..|.|....||.||    
 Worm   187 SPSYAMMNDVDIGDHDDEEDDDGPADFTDMPLLKPVDEDDDCYD-VPCTSEGPPPNNSNPA---- 246

Human  1603 HTNLFTSAIGSCRVSNPNSSG-------------------------RKKLTDSPGLFSAQDTSLN 1642
                .|:...||....|....                         |:.:...|.:..|....:.
 Worm   247 ----ITTIPSSCSTPAPPKESLPTGMNVEEWGSFLIASNMDREEIVRRLMAHDPEMAKAIAMRIR 307

Human  1643 RLHRKESLPSNERAVQTLAGSQPTSDKPSQRPSESTNCSPTRKRSSSESTSSTVNGVPSRSPRLV 1707
            .|..:||....:...: ::.:.||:  |..|.:.:.|...||..:|.:.|:|.:...||.|...:
 Worm   308 ELSAEESKKKKDMEAE-VSSTTPTT--PRARGTRTRNKCATRSTNSPDVTTSNLPEEPSTSTMGL 369

Human  1708 ASGDDSVDSL----------LQRMVQNEDQEPMEKSIDAVIATASAPPSSSPGRSHSKDRTLGKP 1762
            ...::.|:.:          .:|....|..|.:|.  ||..:.|.......|..|.|     .:|
 Worm   370 VKENEDVEKVEGKRRGRKPKKRRGFHKESFEDLES--DAKKSKAEQHEDHLPEASCS-----SRP 427

Human  1763 DSLLVPAVTSDSCNNSISLLSEKLTSSCSPHHIKRSVVEAMQRQARKMCNYDKILATKKNLDHVN 1827
            :|::.|.|                    .|...:..|.|.|:|:..::........|:..|.|: 
 Worm   428 ESVIPPPV--------------------DPIQFRLKVREMMERKLEQLTQKMSEDMTELRLSHL- 471

Human  1828 KILKAKKLQRQARTGNNFVKRRPGRPRKCPLQAVVSMQAFQAAQFVNPELNRDEEGAALHLSPDT 1892
                         |.:..|....|:.|:..|:                                 
 Worm   472 -------------TSSKMVNGERGKRRESFLR--------------------------------- 490

Human  1893 VTDVIEAVVQSVNLNPEHKKGLKRKGWLLEEQTRKKQKPLPEEEE--QENNKSFNEAPVEIPSPS 1955
                        .||.:.||  .|||.:|   .||:.:....|.:  :||..:..:...|..:|.
 Worm   491 ------------QLNEQSKK--LRKGGML---GRKRLRMFMTESDILEENKDNIKKEVKEESTPP 538

Human  1956 ETPAKPSEPESTLQPVLSLIPREKKPPRPPKKKYQKAGLYSDVYKTTDPKSRLIQLKKEKLEYTP 2020
            .|..:...|....:.     |.|...|.|.:||:.  |.|.::.|:. |.|.             
 Worm   539 PTKLRGRLPSRRTRE-----PSEIVNPEPVEKKFN--GEYFEITKSV-PSSD------------- 582

Human  2021 GEHEYGLFPAPIHVVFFVSGKYLRQKRIDFQLPYDILWQWKHNQLYKKPDVPLYKKIRSNVYVDV 2085
                                                                           |:
 Worm   583 ---------------------------------------------------------------DI 584

Human  2086 KPLSGYEATTCNCKKPDDDTRKGCVD--DCLNRMIFAECSPNTCPCGEQCCNQRIQRHEWVQCLE 2148
            .||....:.||.|      |:..|..  |||||.:..:||.:   |....|:.|           
 Worm   585 IPLWMAPSLTCGC------TKGACTSDMDCLNRALRVQCSSD---CSVPYCSNR----------- 629

Human  2149 RFRAEEKG------WGIRTKEPLK------AGQFIIEYLGEVVSEQEFRNRMIEQYHNHSDHYCL 2201
            ||..|:.|      .|.|:|..||      ||:|:.||.|||::.::.:    |::....|...:
 Worm   630 RFWKEDCGNKLCVSNGPRSKRVLKTKIARRAGEFLCEYAGEVITREQAQ----EKFAQDRDPRII 690

Human  2202 NLDSGMVIDSYRMGNEARFINHSCDPNCEMQKWSVNGVYRIGLYALKDMPAGTELTYDYNFHSFN 2266
            .:.:.:.:|:.:..|.||||.|||.||..::.|||||.||.|::||.|:....|:|         
 Worm   691 AIAAHLFVDATKRSNIARFIKHSCKPNSRLEVWSVNGFYRAGVFALSDLNPNAEIT--------- 746

Human  2267 VEKQQL------CKCGFEKCRGIIGGKSQRVNGLTSSKNSQPMATHKKSGRSKEKRKSKHKLKKR 2325
            |:|..|      |.||..:|:.:|.|...|                                   
 Worm   747 VDKSDLLPFDMACNCGATECKRVIRGVRWR----------------------------------- 776

Human  2326 RGHLSEEPSENINTPTRLTPQLQMKPMSNRERNFVLKHHVFLVRNWEKIRQKQEEVKHTSDNIHS 2390
                ..:|:|.|.|                 |.||             ||.:::.::.:|.:...
 Worm   777 ----CADPNEKIVT-----------------RRFV-------------IRNRRKTIERSSHSGLP 807

Human  2391 ASLYTRWNGICRDDGNIKSDVFMTQFSALQTARSVRTRRLAAAEENIEVARAARLAQIFKEICDG 2455
            |.|.|..      |.|....:.|.|..|   |.:.|.|::                       ||
 Worm   808 AILQTPM------DENSSIRLKMKQVLA---AFAFRVRKI-----------------------DG 840

Human  2456 IISYKDSSRQALAAPLLNLPPKKKNADYYEKISDPLDLITIEKQILTGYYKTVEAFDADML-KVF 2519
            .:|........|....|.......|         |::.:::       :.|.:||.|.|.| :.|
 Worm   841 SMSRTMLPHYTLIIKFLKTKGNNPN---------PVEFVSL-------FRKWLEAIDDDDLERAF 889

Human  2520 RNAEKYYGRKSPVGRDVCRLRKAYYNA-RHEA-SAQIDEIVGETASEADSSETSVSEKENGHEKD 2582
            ...|.:|...|.:...: :.:||..|| |..| |......|.....:||.|..........::.|
 Worm   890 VAIESHYMSSSILSSSL-QSKKAKDNAPRARALSTSCPSPVPSKRGDADLSYLESLYPIGSYDPD 953

Human  2583 D-----------DVIRCICGLYKDEGLMIQCDKCMVWQHCDC--------------MGVNSDVEH 2622
            |           :.:|||||...:||.|:|||.|..|.|.||              ....||...
 Worm   954 DAWESYSTNKKGNAVRCICGALDEEGTMVQCDTCHFWLHVDCCQYVVRSNEKAQKSKNPPSDDGE 1018

Human  2623 YLCEQCDP-----RPVDREVPMIPRPHYAQPGCVYFICLL-RDDLLLRQGDCVY----------- 2670
            |:|:.|..     || ..:|.:..:|......|.|:..|: |..:.:...:.||           
 Worm  1019 YICDFCTNKQNGLRP-SADVKLTEQPDVRFENCDYYRSLINRRGIQVVLNETVYVNRVLPEDHKA 1082

Human  2671 LMRDSRRTPDGHPVRQS--YRL---------LSHINRDKLDIFRIEKLWKNEKEERFAFGHHYFR 2724
            ::|:.|....|...:.:  ||.         :..::|....|||:|:|:......||.||..|..
 Worm  1083 MLRNLREEKKGSKQKDTNKYRFPKAATSPLPIEKVDRKNARIFRVERLFVCPGNNRFVFGSFYAW 1147

Human  2725 PHETHHSPSRRFYHNELFRVPLYEIIPLEAVVGTCCVLDLYTYCKGRPK--GVKEQDVYICDYRL 2787
            ||||:....|.|...|:|..|.||.:||:.|:|.|.|||..|:||||||  ..||.||::|:.::
 Worm  1148 PHETYADAGRVFSKKEVFATPYYETLPLDEVIGRCLVLDTATWCKGRPKVPKFKEDDVFLCEMQI 1212

Human  2788 DKSAHLFYKI-HRNRYPVCTKPYAFDHF--PKKLTPKKDFSPHYVPDNYKRNGGRSSWKSERSK- 2848
            .|:..:|.|: .:||||:.|..|.|..|  |||:.  :||.| |.|.|......::|.....|. 
 Worm  1213 GKTQRVFEKVPPKNRYPINTNSYVFTEFTHPKKVV--RDFRP-YDPSNPSPKPPKTSSIPSTSSI 1274

Human  2849 -PPLKDLGQEDDALPLIE 2865
             ||    ....|.||.::
 Worm  1275 DPP----QSSSDGLPEVD 1288

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
ASH1LNP_001353106.1 Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 1..70
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 118..143
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 501..525
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 537..583
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 824..845
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 878..966
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 1100..1128
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 1151..1231
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 1243..1281
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 1489..1508
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 1580..1711 30/155 (19%)
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 1741..1761 4/19 (21%)
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 1911..1991 21/81 (26%)
Catalytic domain 2069..2288 70/238 (29%)
AWS 2092..2143 CDD:197795 15/52 (29%)
SET_ASH1L 2146..2286 CDD:380951 51/157 (32%)
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 2288..2346 5/57 (9%)
Bromo_ASH1 2443..2548 CDD:99955 21/106 (20%)
PHD_ASH1L 2586..2628 CDD:277023 20/55 (36%)
BAH_polybromo 2665..2799 CDD:240068 52/158 (33%)
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 2825..2856 8/32 (25%)
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 2876..2919
lin-59NP_491206.1 AWS 591..636 CDD:197795 18/64 (28%)
SET 629..772 CDD:394802 52/166 (31%)
PHD 970..1027 CDD:425785 20/56 (36%)
BAH_polybromo 1118..1222 CDD:240068 44/103 (43%)
Blue background indicates that the domain is not in the aligned region.

Return to query results.
Submit another query.