DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment ASH1L and set2

DIOPT Version :9

Sequence 1:	NP_001353106.1	Gene:	ASH1L / 55870	HGNCID:	19088	Length:	2969	Species:	Homo sapiens
Sequence 2:	NP_594980.1	Gene:	set2 / 2542070	PomBaseID:	SPAC29B12.02c	Length:	798	Species:	Schizosaccharomyces pombe

Alignment Length:	999	Identity:	211/999 - (21%)
Similarity:	371/999 - (37%)	Gaps:	306/999 - (30%)

- Green bases have known domain annotations that are detailed below.

Human  1931 PLPEEEEQENNKSFNEAPVEIPSPSETPAKPSEPESTLQPVLSLIPREKKPPRPPKKKYQKAGLY 1995
            || .||..:...|:::..:.:.:...:|:..|..:...:.....:.:::..|.|
pombe    12 PL-NEENVDRKSSWSKDTIAVQAVGSSPSSSSSHDFESKEDAEGMNKDESAPSP----------- 64

Human  1996 SDVYKTTDPKSRLIQLKKEKLEYTPGEHEYGLFPAPIHVVFFVSGKYLRQKRIDFQLPYDILWQW 2060
                .|:.|.|...:.:                           .||:|::.:..||       :
pombe    65 ----STSSPSSASSRSQ---------------------------SKYVRKEALPPQL-------F 91

Human  2061 KHNQLYKKPDVPLYKKIRSNVYVDV---KPLSGYEATTCNCKKPD--DDTRKGC--VDDCLNRMI 2118
            .|....|...:..:::|:...|...   ||... ||..|:| :|.  |.....|  ..:|:|||.
pombe    92 HHLDSAKDKALTTFEEIQECQYASANIGKPPEN-EAMICDC-RPHWVDGVNVACGHGSNCINRMT 154

Human  2119 FAECSPNTCPCGEQCCNQRIQRHEWVQCLERFRAEEKGWGIRTKEPLKAGQFIIEYLGEVVSEQE 2183
            ..||:.....||..|.|||.||||:.: ::.|..|:||:|:|....|....|:.||:|||:.||:
pombe   155 SIECTDEDNVCGPSCQNQRFQRHEFAK-VDVFLTEKKGFGLRADANLPKDTFVYEYIGEVIPEQK 218

Human  2184 FRNRMIEQYHNH--SDHYCLNLDSGMVIDSYRMGNEARFINHSCDPNCEMQKWSVNGVYRIGLYA 2246
            ||.|| .||.:.  ...|.:.|..|..||:.:.|:.|||.||||.|||.:.||.|....|:|::.
pombe   219 FRKRM-RQYDSEGIKHFYFMMLQKGEYIDATKRGSLARFCNHSCRPNCYVDKWMVGDKLRMGIFC 282

Human  2247 LKDMPAGTELTYDYNFHSFNVEKQQLCKCGFEKCRGIIGGKSQRVNGLTSSKNSQPMATHKKSGR 2311
            .:|:..|.|||:|||...:..:.|. |.||...|.|.||||:|     |.:::..|....:..|
pombe   283 KRDIIRGEELTFDYNVDRYGAQAQP-CYCGEPCCVGYIGGKTQ-----TEAQSKLPENVREALG- 340

Human  2312 SKEKRKSKHKLKKRRGHLSEEPSENINTPTRLTPQLQMKPMSNRERNFVLKHHVFLVRNWEKI-- 2374
            .:::..|...:..||    :...:.|:..:::..::|..|:::.....|:.   .|::..:.:
pombe   341 IEDEEDSWENITARR----QRRKKGIDETSKIIEEVQPTPLTSESATKVIG---VLLQTKDDLLT 398

Human  2375 RQKQEEVKHTSDNIHSASLYTRWNGICRDDGNIKS-DVF---MTQFS--------ALQTARS-VR 2426
            |:..|.:..|||           ..:||....::. ::|   :.:||        :::|..| .|
pombe   399 RKLMERIFLTSD-----------PSVCRSIIALRGYNIFGLMLKKFSIDIEFILRSIKTMLSWPR 452

Human  2427 TRRLAAAEENIEVARAARLAQIFKEICDGIISYKDSSRQALAAPLLNLPPKKKNADYYEKISDPL 2491
            ..|....:.|||        .:.:|.||                       .:|    |::.|
pombe   453 LTRNKIQDSNIE--------PVVQEFCD-----------------------HEN----EEVKD-- 480

Human  2492 DLITIEKQILTGYYKTVEAFDADMLKVFRNAEKYY--GRKSPVGRDVCRLRKAYYNARHEASAQI 2554
                        :.||       :||.:.:.|..|  .|:.|
pombe   481 ------------HAKT-------LLKEWESLEIAYRIPRRKP----------------------- 503

Human  2555 DEIVGETASEADSSETSVSEKENGHEKDDDVIRCICGLYKDEGLMIQCDKCMVWQHCDCMGVNSD 2619
                |:.|.::.::|.| :.:.|...:|.:..|...|..|.                   .:|:.
pombe   504 ----GQVAPQSTNAEPS-NNQSNPPLRDQEPQRGDKGDIKS-------------------AINNS 544

Human  2620 VEHYLCEQCDPRPVDREVPMIPRPHYAQPGCVYFICLLRDDLLLRQGDCVYLMRDSR-RTPDGHP 2683
            .|          .:.::.|.:   |.::|.                        ||| |:..|:.
pombe   545 TE----------DLSKKHPAL---HSSRPS------------------------DSRSRSKFGND 572

Human  2684 VRQSYRLLSHINRDKLDIFRIEKLWKNEKEERFAFGHHYFRPHETHHSPSRRFYHNELFRVPLYE 2748
            .:      ||   .|.::||     ||...:|....:.......|..:..:....|:..:|.|.:
pombe   573 YQ------SH---SKHNLFR-----KNSFPKRRRLSNSDTPSETTTPNNEQEQVSNQANKVDLNK 623

Human  2749 II--PLEAVVGTCCVLDLYTYCKGRPKGVKEQDVYICDYRLDKSAHLFY---------KIHRNRY 2802
            ||  .:|:|           ..|...|..||::..|...:.::...|.|         |:|..:
pombe   624 IISAAMESV-----------NQKNVLKAQKEEEERIAQQKREEKRRLAYEESLKRHAKKLHEKK- 676

Human  2803 PVCTKP--------YAFDHFPKKLTPKKDFSPHYV--PDNYKRNGGRSSWKSERSKPP---LKD- 2853
               ||.        :...|.|:.:..|...:..:.  ...|:...|::.:|....|..   ||.
pombe   677 ---TKSSQDATIDHHLTSHSPESIAFKAVLAKFFANKTARYQEKLGKAEFKLRVKKMTEIILKKH 738

Human  2854 ----LGQEDDALPLIEEVLASQEQ 2873
                |.:::.|||  :|:..||::
pombe   739 IQLVLSKKEKALP--DELSDSQQR 760

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
ASH1L	NP_001353106.1	Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	1..70
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	118..143
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	501..525
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	537..583
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	824..845
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	878..966
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	1100..1128
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	1151..1231
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	1243..1281
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	1489..1508
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	1580..1711
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	1741..1761
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	1911..1991		9/59 (15%)
		Catalytic domain	2069..2288		86/227 (38%)
		AWS	2092..2143	CDD:197795	22/54 (41%)
		SET	2146..2266	CDD:214614	50/121 (41%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	2288..2346		8/57 (14%)
		Bromo_ASH1	2443..2548	CDD:99955	14/106 (13%)
		PHD_ASH1L	2586..2628	CDD:277023	5/41 (12%)
		BAH_polybromo	2665..2799	CDD:240068	29/145 (20%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	2825..2856		7/40 (18%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	2876..2919
set2	NP_594980.1	AWS	125..179	CDD:197795	22/54 (41%)
		SET	180..303	CDD:214614	50/124 (40%)
		SET	275..791	CDD:225491	125/682 (18%)
		PostSET	304..320	CDD:214703	6/16 (38%)
		Med26	440..489	CDD:285873	17/104 (16%)
		SRI	699..771	CDD:285448	14/64 (22%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	1	1.030	-	avgDist	Average_Evolutionary_Distance	R4489
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	2	1.940