DRSC/TRiP Functional Genomics Resources

powered by:
logo

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits


Protein Alignment ASH1L and bye1

DIOPT Version :10

Sequence 1:NP_001353106.1 Gene:ASH1L / 55870 HGNCID:19088 Length:2969 Species:Homo sapiens
Sequence 2:NP_001342882.1 Gene:bye1 / 2538700 PomBaseID:SPCC645.13 Length:721 Species:Schizosaccharomyces pombe


Alignment Length:436 Identity:85/436 - (19%)
Similarity:122/436 - (27%) Gaps:204/436 - (46%)


- Green bases have known domain annotations that are detailed below.


Human  2583 DDVIRCICGLYKDEG-LMIQCDKCMVWQHCDCMGV-NSDV-EHYLCEQCDPR-PVDREVPMIPRP 2643
            :.|:||:|...:|.| ..:|||.|..|||..|:|: :.|: |.|.||.|..| .|..:|...|  
pombe    18 ETVVRCVCKSQEDIGDTWVQCDGCDCWQHASCVGLADKDIPESYYCEVCHSRSDVSSQVQNSP-- 80

Human  2644 HYAQPGCVYFICLLRDDLLLRQGDCVYLMRDSRRTPDGHPVRQSYRLLSHINRDKLDIFRIEKLW 2708
                                                                             
pombe    81 ----------------------------------------------------------------- 80

Human  2709 KNEKEERFAFGHHYFRPHETHHSPSRRFYHNELFRVPLYEIIPLEAVVGTCCVLDLYTYCKGRPK 2773
             |:.||           |:|                                 .||....:|..|
pombe    81 -NKDEE-----------HQT---------------------------------ADLLASNEGNEK 100

Human  2774 GVKEQDVYICDYR----LDKSAHLFYKIHRNRYPVCTK----------------PYAFDHFPKKL 2818
            ..:|.:|...|.:    .:..|.|     .:..|..|.                |..      ..
pombe   101 NNEENNVVSSDSKEAITKESGAEL-----ESSEPASTNSNVGMTTRSGRQSPRTPIG------ST 154

Human  2819 TPKKDFSPHYVPDNYKRNG--GRSSWKSERSKPPLKDLGQEDDALPLIEEVLASQEQAANE---- 2877
            |||...||   |...||.|  |.::..::|||...|...::           ||.|.|..|    
pombe   155 TPKSSHSP---PSTRKRRGSVGTTATHTKRSKNAPKTSPKD-----------ASNETADQEKELS 205

Human  2878 ----IPSLEEPEREG-ATANVSEGEKKTEESS-------QEPQSTCTPEERRH------------ 2918
                |..::.|.|:. |.|.||..||..|::.       ::..||....:..|            
pombe   206 LHTSIDEIQNPVRKSVAKAWVSVFEKIIEKAKLEGVQGLEDLNSTSLALQLEHIMFMVLSYTTDH 270

Human  2919 ------NQRERLNQILLNLL-EKIPG------KNAIDVTYLLEEGS 2951
                  ..||:...:..||: :|.|.      ||.|....|:...|
pombe   271 SLTPNNKYREKFRALRFNLVDDKNPAFRARVLKNEISFNDLVNLSS 316

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
ASH1LNP_001353106.1 Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 1..70
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 118..143
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 501..525
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 537..583
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 824..845
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 878..966
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 1100..1128
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 1151..1231
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 1243..1281
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 1489..1508
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 1580..1711
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 1741..1761
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 1911..1991
Catalytic domain 2069..2288
AWS 2092..2143 CDD:197795
SET_ASH1L 2146..2286 CDD:380951
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 2288..2346
Bromo_ASH1 2443..2548 CDD:99955
PHD_ASH1L 2586..2628 CDD:277023 19/44 (43%)
BAH_polybromo 2665..2799 CDD:240068 14/137 (10%)
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 2825..2856 11/32 (34%)
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 2876..2919 14/76 (18%)
bye1NP_001342882.1 PHD_SF 22..66 CDD:473978 19/43 (44%)
TFS2M 215..330 CDD:128786 23/102 (23%)
SPOC_TFIIS 483..625 CDD:439201
Blue background indicates that the domain is not in the aligned region.

Return to query results.
Submit another query.