|
Human 1 MDPRNTAMLGLGSDSEGFSRKSPSAISTGTLVSKREVELEKNTKEEEDLRKRNRERNIEAGKDDG 65
||.|:.|||.|..:.| :.|:|:...|.::.:.| .:....||
Frog 1 MDHRDLAMLALAPNVE--------------IASRRDAPQEPSSTQSE----------AQQCPGDG 41
Human 66 LTDAQQQFSVKETNFSEGNLKLKIGLQAKRTKKPPKNLENYVCRPAIKTTIKHPRK-ALKSGKMT 129
.. .|||||..|.||||:.|||||||||||||||||||||||||||||:.|..|| ..|.|.:.
Frog 42 AD--PQQFSVTHTIFSEGHFKLKIGLQAKRTKKPPKNLENYVCRPAIKTSNKCTRKLPPKGGNLP 104
Human 130 DEKNEHCPSKRDPSKL--YKKADDVAAIECQSEEVIRLHSQGENNPLSKKLSPVHSEMADYINAT 192
:||.:..|.|:||:.. .|.|:|....|| ||...|...:| ::|..:.:...::|.
Frog 105 EEKRDGLPPKQDPATTPSRKAAEDSPESEC-------LHRSKEQEKVS--VAPNSAPLPTDVHAQ 160
Human 193 PSTLLGSRDPDLKDRAL-LNGGTSVTEKLAQLIATCPPSKSSKTKPKKLGTGTTAGLVSKDLIRK 256
|.| |. :.||| .:..:|||||||||||||||:||||::.||.......|..||:|
Frog 161 PDT------PP-RPRALGPSSASSVTEKLAQLIATCPPAKSSKSRVKKQANAGPNGTPSKEL--- 215
Human 257 AGVGSVAGIIHKDLIKKPTISTAVGLVTKDPGKKPVFNAAVGLVNKDSVKKLGTGTTAVFINKNL 321
|..|. .:|...: ||.| || :|:.|.:::.
Frog 216 -GAASA---------YEPASDS-----TKPP------NA----------------STSTFCSEDK 243
Human 322 GKKPGTITTVGLLSKDSGKKLGIGIVPGLVHKESGKKLGLGTVVGLVNKDLGKKLGSTVGLVAKD 386
.|:| ||| :.|.|.:
Frog 244 EKQP---------------------VPG--------RQGNGAI---------------------- 257
Human 387 CAKKIVASSAMGLVNKDIGKKLMSCPLAGLISKDAINLKAEALLPTQEPLKASCSTNINNQESQE 451
Frog 258 ----------------------------------------------------------------- 257
Human 452 LSESLKDSATSKTFEKNVVRQNKESILEKFSVRKEIINLEKEMFNEGTCIQQDSFSSSEKGSYET 516
:|...||.:|.:.||.|...|: .:.:...|...|..|||..:|
Frog 258 --------------DKGNQRQAQEGLKEKLSAMNEL--------GDSSSTPQGGVSLGEKGLPDT 300
Human 517 SKHEKQPPVYCTSPDFKMGGASDVSTAKSPFSAVGESNLPSPSPTVSVNPLTRSPPET-----SS 576
:..||..||||||.||:||||||.||||||||||||.|||||:|..||...:|||..| ||
Frog 301 NLQEKMLPVYCTSLDFRMGGASDASTAKSPFSAVGEGNLPSPAPATSVTSFSRSPNGTFPHSPSS 365
Human 577 QLAPNPLLLSSTTELIEEISESVGKNQFTSESTHLNVGHRSVGHSISIECKGIDKEVNDSKTTH- 640
.|..||: :.|..::.:: |:.|.|::.....||.:..||:..:....:|...:....|
Frog 366 SLHLNPV----SAECSDQPTD---KSPFASDNLPGTRGHPTAPHSLDSDTVRSNKRSEEYSGAHS 423
Human 641 --IDIPRISSSLGKKPSLTSESSIHTITPSVVNFTSLFSNKPFLKLGAV--SASDKHCQVAESLS 701
:....:.|:|...| .:.|.|...||||:|.||...:..||:.:: :|:::| .:.|.:
Frog 424 EKMSRTHLPSTLRMPP---KQPSSHKSEPSVVSFASLLRKQRQLKISSMAGAAAERH--FSSSQA 483
Human 702 TSLQSKPLKKRKGRKPRWTKVVARSTCRSPKGLELERSELFKNVSCSSLSNSNSEPAKFMKNIGP 766
||.|:|.||||||:||:|||||::||.:..|..:|...| ||: :.||.
Frog 484 TSHQAKCLKKRKGKKPKWTKVVSKSTGQCAKLGQLPEQE--------SLA----------RGIGR 530
Human 767 PSFVDHDFLKRRLPKLSKSTAPSLALLADSEKPSHKSFATHKLSSSMCVSSDLLSDIYKPKRGRP 831
...:.| .||.:.||. |.||:||.:.:|:..||:|.|.|| .:|.|:.|
Frog 531 APLLAH---------TSKGSIPSA-----SHKPTHKLYESHRTYSSLCASRDL---FHKSKKCR- 577
Human 832 KSKEMPQLEGPPKRTLKIPASKVFSLQSKEEQEPPILQPEIEIPSFKQGLSVSPFPKKRGRPKRQ 896
|::||.|:.|||..|:|..||:.|.|||||..|||||||:|||..:...|...||||||||:||
Frog 578 -SQDMPHLDVPPKWALQISPSKLISSQSKEEPGPPILQPEVEIPPAQVSQSGQLFPKKRGRPRRQ 641
Human 897 MRSPVKMKPPV-LSVAPFVATESPSKLESESDNHRSSSDFFESEDQLQDPDDLDDSHRPSVCSMS 960
:..|| :|||. ||:|| .||.. :|:......::.|.|..| .|| .|
Frog 642 LAPPV-LKPPCGLSLAP---NESIG-VEASGAGCGANMDPFGEE-----------PHR-----AS 685
Human 961 DLEMEPDKKITKRNNGQLMKTIIRKINKMKTLKRKKLLNQILSSSVESSNKGKVQSKLHNTVSSL 1025
|...|..:|...|.||||:||||||||||||:||:||::||||...|.| .:||.:|..:||||
Frog 686 DQCPESGRKALNRGNGQLVKTIIRKINKMKTIKRRKLVSQILSGGTEPS--AQVQPRLQGSVSSL 748
Human 1026 AATFGSKLGQQINVSKKGTIYIGKRRGRKPKTV-LNGIL---SGSPTSLAVLEQTAQQAAGSALG 1086
||||.||||||||||||||||||||||||||.. |:.:| |..|.|| ||...|..|.|.
Frog 749 AATFSSKLGQQINVSKKGTIYIGKRRGRKPKVAPLDCLLAKNSTCPPSL--LESLGQPLAAST-- 809
Human 1087 QILPPLLPSSASSSEILPSPICSQSSGTSGGQSPVSSDAGFVEPSSVPYLHLHS-RQGSMIQTLA 1150
:.||:||.:|:||||.....|.|||..|||||||.||||||:.|||:|| |..|.:||||
Frog 810 -----IQPSAASCAEVLPSPSSCHLSATSGALSPVSSDASFVEPSSLSYLHMHSARHNSALQTLA 869
Human 1151 MKKASKGRRRLSPPTLLPNSPSHLSELTSLKEATPSPISESHSDETIPSDSGIGTDNNSTSDRAE 1215
|:||:|..|:|||||||||||:|:|||:|||||||||||||||||||||||||||||||||||||
Frog 870 MRKAAKDGRQLSPPTLLPNSPAHISELSSLKEATPSPISESHSDETIPSDSGIGTDNNSTSDRAE 934
Human 1216 KFCGQKKRRHSFEHVSLIPPETSTVLSSLKEKHKHKCKRRNHDYLSYDKMKRQKRKRKKKYPQLR 1280
|.||||:|||||||:.|:|.|.|.:|||||||||||||.|.||:|||||:|||||||||||||||
Frog 935 KLCGQKRRRHSFEHMPLMPVEPSVLLSSLKEKHKHKCKHRGHDFLSYDKIKRQKRKRKKKYPQLR 999
Human 1281 NRQDPDFIAELEELISRLSEIRITHRSHHFIPRDLLPTIFRINFNSFYTHPSFPLDPLHYIRKPD 1345
..|||||:|||||||.|||::|||||:||||||||||||||:|||:||:||:|||:||||||||:
Frog 1000 VHQDPDFLAELEELIGRLSDVRITHRTHHFIPRDLLPTIFRLNFNNFYSHPTFPLEPLHYIRKPN 1064
Human 1346 LKKKRGRPPKMREAMAEMPFMHSLSFPLSSTGFYPSYGMPYSPSPLTAAPIGLGYYGRYPPTLYP 1410
||||||||||:||.:.||||||||.||||.|||||||||||||||||..||||.||||||||:||
Frog 1065 LKKKRGRPPKLRETIGEMPFMHSLGFPLSGTGFYPSYGMPYSPSPLTPPPIGLSYYGRYPPTIYP 1129
Human 1411 PPPSPSFTTPLPPPSYM-HAGHLLLNPAKYHKKKHKLLRQEAFLTTSRTPLLSMSTYPSVPPEMA 1474
||||||||||||||||| ||||||||||||||||||||||||||.|.|.|||||.||||||||||
Frog 1130 PPPSPSFTTPLPPPSYMHHAGHLLLNPAKYHKKKHKLLRQEAFLGTGRAPLLSMGTYPSVPPEMA 1194
Human 1475 YGWMVEHKHRHRHKHREHRSSEQPQVSMD--TG--SSRSVLESLKRYRFGKDAVGERYKHKEKHR 1535
|.||.||||||||||||||..:|.|:|:| || |||||||||||||||||:..:|||||:|||
Frog 1195 YSWMFEHKHRHRHKHREHRLPDQAQLSIDPLTGVSSSRSVLESLKRYRFGKDSASDRYKHKDKHR 1259
Human 1536 CHMSCPHLSPSKSLINREEQWVHREPSESSPLALGLQTPLQIDCSESSPSLSLGGFTPNSEPASS 1600
||::|||||||:.|::|:|.|..|:..|:..|:|||.:|||||||:|||..|:|||||:||.|||
Frog 1260 CHLACPHLSPSQGLLSRDEHWARRDSPETHSLSLGLHSPLQIDCSDSSPGRSIGGFTPSSEQASS 1324
Human 1601 DEHTNLFTSAIGSCRVSNPNSS--GRKKLTDSPGLFSAQDTSLNRLHRKESLPSNERAVQTLAGS 1663
||||||||||||:||.|...|. |||.|.::...| .|::|:|..||| |.::|..|.|:..
Frog 1325 DEHTNLFTSAIGNCRPSGSVSGPVGRKALNENSPFF--MDSTLSRSLRKE--PPSDRLAQALSVP 1385
Human 1664 QPTSDKPSQRPSESTNCSPTRKRSSSESTSSTVNGVPSRSPRLVASGDDSVDSLLQRMVQNEDQE 1728
| :.|.|.|:.::|||:|:|:.|||.|..:.||.:|..|:.:.||||.:..:||:|.||..:
Frog 1386 Q----ERSLRQSDRSSCSPSRRRTPSESPSPALMGVGARGTRMGSLGDDSAEPFVQRIVHNEKPD 1446
Human 1729 PMEKSIDAVIATASAPPSSSPGRSHSKDRTLGKPDSLLVPAVTSDSCNNSISLLSEKLTSSCSPH 1793
.:|||:.......|.|.|....|.||::|:....: |..:.:|.|......|.::.|.||..
Frog 1447 TLEKSVGVQCPIGSVPASGGSSRGHSRERSQENRN----PTASIESYNGPGPASSRQVGSGCSSQ 1507
Human 1794 HIKRSVVEAMQRQARKMCNYDKILATKKNLDHVNKILKAKKLQRQARTGNNFVKRRPGRPRKCPL 1858
.:|||:|||:.::||:|.:||:|||:|||||||||||||||||||:||||||||||||||||.|:
Frog 1508 QLKRSMVEAIHKRARRMYSYDRILASKKNLDHVNKILKAKKLQRQSRTGNNFVKRRPGRPRKYPV 1572
Human 1859 QAVVSMQAFQAAQFVNPELNRDEEGAALHLSPDTVTDVIEAVVQSVNLNPEHKKGLKRKGWLLEE 1923
.::.:.|.|.. :..||||||||||||||:|..|..||.|||...|::
Frog 1573 DSLQAAQLFPI------------------MRSDTVTDVIEAVVQSVSLRDEQHKGWKRKHLELDK 1619
Human 1924 QTRKKQKPLPEEEEQENNKSFNE-APVEIPSPSETPAKPSEPESTLQPVLSLIP---REKKPPRP 1984
|.:|:.|.| .|::||:|.|.:| |.||.|:..:....| |.|.....:.::.| ::||.|||
Frog 1620 QVKKRPKSL-YEDDQESNISLSECAIVEAPAAPDISGNP-EVERAGDLLHTMAPPPQKQKKAPRP 1682
Human 1985 PKKKYQKAGLYSDVYKTTDPKSRLIQLKKEKLEYTPGEHEYGLFPAPIHVVFFVSGKYLRQKRID 2049
||||||||||:||:|||.||||||:|||||||||.|.||||||.|||||: ||||||||.|
Frog 1683 PKKKYQKAGLFSDMYKTLDPKSRLVQLKKEKLEYDPREHEYGLLPAPIHI-----GKYLRQKRND 1742
Human 2050 FQLPYDILWQWKHNQLYKKPDVPLYKKIRSNVYVDVKPLSGYEATTCNCKKPDDDTRKGCVDDCL 2114
|||||||||||||||||||||||||||||||||||||||||||||.||||.||:.:.||||:|||
Frog 1743 FQLPYDILWQWKHNQLYKKPDVPLYKKIRSNVYVDVKPLSGYEATMCNCKCPDNQSEKGCVEDCL 1807
Human 2115 NRMIFAECSPNTCPCGEQCCNQRIQRHEWVQCLERFRAEEKGWGIRTKEPLKAGQFIIEYLGEVV 2179
|||||||||||||||||||.||.||||||||||||||||.|||||||||||||.|||||||||||
Frog 1808 NRMIFAECSPNTCPCGEQCNNQCIQRHEWVQCLERFRAEGKGWGIRTKEPLKASQFIIEYLGEVV 1872
Human 2180 SEQEFRNRMIEQYHNHSDHYCLNLDSGMVIDSYRMGNEARFINHSCDPNCEMQKWSVNGVYRIGL 2244
||.|||||.|||||||||||||:||||||||||||||||||||||||||||||||||||||||||
Frog 1873 SETEFRNRTIEQYHNHSDHYCLSLDSGMVIDSYRMGNEARFINHSCDPNCEMQKWSVNGVYRIGL 1937
Human 2245 YALKDMPAGTELTYDYNFHSFNVEKQQLCKCGFEKCRGIIGGKSQRVNGLTSSKNSQPMATHKKS 2309
||||||||||||||||||||||.||||:||||.||||||||||||||||| ::|....:.:.::.
Frog 1938 YALKDMPAGTELTYDYNFHSFNTEKQQVCKCGVEKCRGIIGGKSQRVNGL-ANKGGHLVPSQRRL 2001
Human 2310 GRSKEKRKSKHKLKKRRGHLSEEPSENINTPTRLTPQLQMKPMSNRERNFVLKHHVFLVRNWEKI 2374
|||||||||||:||||:||..|:.|:.|.||:||.|||.||||||||||||||||||||||||||
Frog 2002 GRSKEKRKSKHRLKKRKGHFPEDRSDAIGTPSRLGPQLHMKPMSNRERNFVLKHHVFLVRNWEKI 2066
Human 2375 RQKQEEVKHTSDNIHSASLYTRWNGICRDDGNIKSDVFMTQFSALQTARSVRTRRLAAAEENIEV 2439
||:.|||| ||:...|||:||:.:.||||||||||||||||||||:||||||||||||||.||
Frog 2067 RQRHEEVK---DNLPPGSLYSRWSSMGRDDGNIKSDVFMTQFSALQTSRSVRTRRLAAAEENTEV 2128
Human 2440 ARAARLAQIFKEICDGIISYKDSSRQALAAPLLNLPPKKKNADYYEKISDPLDLITIEKQILTGY 2504
|||||||.|||||.||||.|||.|.:.||:|||:||.||||..||||:||||||:::|||||||:
Frog 2129 ARAARLAHIFKEISDGIICYKDFSNRPLASPLLSLPNKKKNPHYYEKVSDPLDLLSVEKQILTGH 2193
Human 2505 YKTVEAFDADMLKVFRNAEKYYGRKSPVGRDVCRLRKAYYNARHEASAQIDEIVGETASEADSSE 2569
||||||||.||||||||||||:||||.|||||||||||||:|||||:||||||||||||||||||
Frog 2194 YKTVEAFDTDMLKVFRNAEKYHGRKSQVGRDVCRLRKAYYSARHEAAAQIDEIVGETASEADSSE 2258
Human 2570 TSVSEKENGHEKDDDVIRCICGLYKDEGLMIQCDKCMVWQHCDCMGVNSDVEHYLCEQCDPRPVD 2634
||:.:|:.|||||||:|||||||:|||||||||:|||||||||||||.|||||||||||:|||||
Frog 2259 TSLFDKDGGHEKDDDIIRCICGLFKDEGLMIQCEKCMVWQHCDCMGVTSDVEHYLCEQCNPRPVD 2323
Human 2635 REVPMIPRPHYAQPGCVYFICLLRDDLLLRQGDCVYLMRDSRRTPDGHPVRQSYRLLSHINRDKL 2699
|||||||.|||||||.:||||||||||||||||||||||||||||||.||||||||||||||:||
Frog 2324 REVPMIPCPHYAQPGFIYFICLLRDDLLLRQGDCVYLMRDSRRTPDGQPVRQSYRLLSHINREKL 2388
Human 2700 DIFRIEKLWKNEKEERFAFGHHYFRPHETHHSPSRRFYHNELFRVPLYEIIPLEAVVGTCCVLDL 2764
|||||||||||||.|||||||||||||||||||||:||:||||||||||||||||||||||||||
Frog 2389 DIFRIEKLWKNEKGERFAFGHHYFRPHETHHSPSRKFYYNELFRVPLYEIIPLEAVVGTCCVLDL 2453
Human 2765 YTYCKGRPKGVKEQDVYICDYRLDKSAHLFYKIHRNRYPVCTKPYAFDHFPKKLTPKKDFSPHYV 2829
||||||||||||||||||||||||||||||||||||||.:|||.|||||||||||||:|||||:|
Frog 2454 YTYCKGRPKGVKEQDVYICDYRLDKSAHLFYKIHRNRYTICTKTYAFDHFPKKLTPKRDFSPHHV 2518
Human 2830 PDNYKRNGGRSSWKSERSKPPLKDLGQEDDALPLIEEVLASQEQAANEIPSLEEPEREGATANVS 2894
|||||||||||:|||:|.|.....|..|:|.||.:.::|.:.|....|.|:.|.||.|.....|:
Frog 2519 PDNYKRNGGRSAWKSDRPKQSSSCLHTEEDPLPTMADLLTNPETCQQENPAPEVPETESPCLEVN 2583
Human 2895 EGEKKTEESSQEPQS-TCTPEERRHNQRERLNQILLNLLEKIPGKNAIDVTYLLEEGSGRKLRRR 2958
| :.||||...|: .|:.:||:..||::||:|||.||:|||||||||||||||||..||||||
Frog 2584 E---QVEESSSTTQAHLCSTQERQQVQRDKLNRILLRLLDKIPGKNAIDVTYLLEEGPCRKLRRR 2645
Human 2959 TLFIPENSFRK 2969
||.:||..|||
Frog 2646 TLTLPECIFRK 2656
| 
