DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment PRKD1 and Prkd1

DIOPT Version :9

Sequence 1:	NP_001316998.1	Gene:	PRKD1 / 5587	HGNCID:	9407	Length:	920	Species:	Homo sapiens
Sequence 2:	XP_038968942.1	Gene:	Prkd1 / 85421	RGDID:	620964	Length:	928	Species:	Rattus norvegicus

Alignment Length:	930	Identity:	863/930 - (92%)
Similarity:	883/930 - (94%)	Gaps:	12/930 - (1%)

- Green bases have known domain annotations that are detailed below.

Human     1 MSAPPVLRPPSPLLPVAAAAAAAAAALVPGSGPGPAPFLAPVAAPVGGISFHLQIGLSREPVLLL 65
            |||||:|||||||||.|||.|||||||||||  |||||.||.|||.|||||||||||||||||||
  Rat     1 MSAPPLLRPPSPLLPAAAAVAAAAAALVPGS--GPAPFPAPGAAPAGGISFHLQIGLSREPVLLL 63

Human    66 QDSSGDYSLAHVREMACSIVDQKFPECGFYGMYDKILLFRHDPTSENILQLVKAASDIQEGDLIE 130
            |||||||||||||||||||||||||||||||:|||||||||||.|||||||||.|||||||||||
  Rat    64 QDSSGDYSLAHVREMACSIVDQKFPECGFYGLYDKILLFRHDPASENILQLVKIASDIQEGDLIE 128

Human   131 VVLSASATFEDFQIRPHALFVHSYRAPAFCDHCGEMLWGLVRQGLKCEGCGLNYHKRCAFKIPNN 195
            |||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
  Rat   129 VVLSASATFEDFQIRPHALFVHSYRAPAFCDHCGEMLWGLVRQGLKCEGCGLNYHKRCAFKIPNN 193

Human   196 CSGVRRRRLSNVSLTGVSTIRTSSAELSTSAPDEPLLSPVSPGFEQKSPSESFIGREKRSNSQSY 260
            ||||||||||||||||:.|:||:|||.||||||||||||||||||||||||||||||||||||||
  Rat   194 CSGVRRRRLSNVSLTGLGTVRTASAEFSTSAPDEPLLSPVSPGFEQKSPSESFIGREKRSNSQSY 258

Human   261 IGRPIHLDKILMSKVKVPHTFVIHSYTRPTVCQYCKKLLKGLFRQGLQCKDCRFNCHKRCAPKVP 325
            :||||.|||:|||||||||||||||||||||||:|||||||||||||||||||||||||||||||
  Rat   259 VGRPIQLDKLLMSKVKVPHTFVIHSYTRPTVCQFCKKLLKGLFRQGLQCKDCRFNCHKRCAPKVP 323

Human   326 NNCLGEVTINGDLLSPGAESDVVMEEGSDDNDSERNSGLMDDMEEAMVQDAEMAMAECQNDSGEM 390
            |||||||||||:|||||||||||||||||||||||||||||||:||||||.|||:||.|:|..||
  Rat   324 NNCLGEVTINGELLSPGAESDVVMEEGSDDNDSERNSGLMDDMDEAMVQDTEMALAEGQSDGAEM 388

Human   391 QDPDPDHEDANRTISPSTSNNIPLMRVVQSVKHTKRKSSTVMKEGWMVHYTSKDTLRKRHYWRLD 455
            ||||.|.||:||||||||||||||||||||||||||:||||||||||||||||||||||||||||
  Rat   389 QDPDADQEDSNRTISPSTSNNIPLMRVVQSVKHTKRRSSTVMKEGWMVHYTSKDTLRKRHYWRLD 453

Human   456 SKCITLFQNDTGSRYYKEIPLSEILSLEPVKTSALIPNGANPHCFEITTANVVYYVGENVVNPSS 520
            ||.||||||||||||||||||||||.|||.|.|||||.|||||||||||||||||||||||||||
  Rat   454 SKSITLFQNDTGSRYYKEIPLSEILCLEPAKPSALIPTGANPHCFEITTANVVYYVGENVVNPSS 518

Human   521 PSPNNSVLTSGVGADVARMWEIAIQHALMPVIPKGSSVGTGTNLH----------RDISVSISVS 575
            |.|||||..||:|.|||||||:|||||||||||||||||:|||.|          .|||||||||
  Rat   519 PPPNNSVPPSGIGTDVARMWEVAIQHALMPVIPKGSSVGSGTNSHSESNDFRLSREDISVSISVS 583

Human   576 NCQIQENVDISTVYQIFPDEVLGSGQFGIVYGGKHRKTGRDVAIKIIDKLRFPTKQESQLRNEVA 640
            |.|||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
  Rat   584 NSQIQENVDISTVYQIFPDEVLGSGQFGIVYGGKHRKTGRDVAIKIIDKLRFPTKQESQLRNEVA 648

Human   641 ILQNLHHPGVVNLECMFETPERVFVVMEKLHGDMLEMILSSEKGRLPEHITKFLITQILVALRHL 705
            |||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
  Rat   649 ILQNLHHPGVVNLECMFETPERVFVVMEKLHGDMLEMILSSEKGRLPEHITKFLITQILVALRHL 713

Human   706 HFKNIVHCDLKPENVLLASADPFPQVKLCDFGFARIIGEKSFRRSVVGTPAYLAPEVLRNKGYNR 770
            |||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
  Rat   714 HFKNIVHCDLKPENVLLASADPFPQVKLCDFGFARIIGEKSFRRSVVGTPAYLAPEVLRNKGYNR 778

Human   771 SLDMWSVGVIIYVSLSGTFPFNEDEDIHDQIQNAAFMYPPNPWKEISHEAIDLINNLLQVKMRKR 835
            |||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
  Rat   779 SLDMWSVGVIIYVSLSGTFPFNEDEDIHDQIQNAAFMYPPNPWKEISHEAIDLINNLLQVKMRKR 843

Human   836 YSVDKTLSHPWLQDYQTWLDLRELECKIGERYITHESDDLRWEKYAGEQGLQYPTHLINPSASHS 900
            ||||||||||||||||||||||||||:||||||||||||.|||:||||||||||.||||.||||.
  Rat   844 YSVDKTLSHPWLQDYQTWLDLRELECRIGERYITHESDDSRWEQYAGEQGLQYPAHLINLSASHG 908

Human   901 DTPETEETEMKALGERVSIL 920
            |:||.||.|||||.||||||
  Rat   909 DSPEAEEREMKALSERVSIL 928

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
PRKD1	NP_001316998.1	C1_1	147..196	CDD:278556	48/48 (100%)
		C1	279..328	CDD:237996	47/48 (98%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	385..410		18/24 (75%)
		PH_PKD	424..551	CDD:269945	114/126 (90%)
		STKc_PKD	587..846	CDD:270984	258/258 (100%)
		S_TKc	595..847	CDD:214567	251/251 (100%)
Prkd1	XP_038968942.1	C1_PKD1_rpt1	138..209	CDD:410389	70/70 (100%)
		C1_PKD1_rpt2	243..336	CDD:410392	88/92 (96%)
		PH_PKD	422..549	CDD:269945	114/126 (90%)
		STKc_PKD	595..854	CDD:270984	258/258 (100%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C83696042
Domainoid	1	1.000	516	1.000	Domainoid score	I6715
eggNOG	1	0.900	-	-		E1_KOG4236
HGNC	1	1.500	-	-
Hieranoid	1	1.000	-	-
Homologene	1	1.000	-	-		H55680
Inparanoid	1	1.050	1735	1.000	Inparanoid score	I2036
NCBI	1	1.000	-	-
OMA	1	1.010	-	-		QHG48438
OrthoDB	1	1.010	-	-		D12448at314146
OrthoFinder	1	1.000	-	-		FOG0002280
OrthoInspector	1	1.000	-	-		oto130164
orthoMCL	1	0.900	-	-		OOG6_103473
Panther	1	1.100	-	-	LDO	PTHR22968
Phylome	1	0.910	-	-
SonicParanoid	1	1.000	-	-		X1509
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
	17	17.310