DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment PRKD1 and prkd1

DIOPT Version :9

Sequence 1:	NP_001316998.1	Gene:	PRKD1 / 5587	HGNCID:	9407	Length:	920	Species:	Homo sapiens
Sequence 2:	XP_005158873.1	Gene:	prkd1 / 557123	ZFINID:	ZDB-GENE-080131-1	Length:	886	Species:	Danio rerio

Alignment Length:	922	Identity:	735/922 - (79%)
Similarity:	797/922 - (86%)	Gaps:	38/922 - (4%)

- Green bases have known domain annotations that are detailed below.

Human     1 MSAPPVLRPPSPLLPVAAAAAAAAAALVPGSGPGPAPFLAPVAAPVGGISFHLQIGLSREPVLLL 65
            ||.|||:||||||               |||               .||||.:|||||||||||
Zfish     1 MSVPPVIRPPSPL---------------PGS---------------QGISFQIQIGLSREPVLL- 34

Human    66 QDSSGDYSLAHVREMACSIVDQKFPECGFYGMYDKILLFRHDPTSENILQLVKAASDIQEGDLIE 130
              .||::|||.||||||||||||||||||||||||||||||||.||||||||::|::|.||||:|
Zfish    35 --DSGEFSLAQVREMACSIVDQKFPECGFYGMYDKILLFRHDPNSENILQLVRSAAEIMEGDLVE 97

Human   131 VVLSASATFEDFQIRPHALFVHSYRAPAFCDHCGEMLWGLVRQGLKCEGCGLNYHKRCAFKIPNN 195
            ||||||||.||||||||||||||||||||||||||||||||||||||||||||||||||||||||
Zfish    98 VVLSASATVEDFQIRPHALFVHSYRAPAFCDHCGEMLWGLVRQGLKCEGCGLNYHKRCAFKIPNN 162

Human   196 CSGVRRRRLSNVSLTGVSTIRTSSAELSTSAPDEPLLSPVSPGFEQKSPSESFIGREKRSNSQSY 260
            |||:|:||||||||||::..|:.|||.|.|..||.|||||||..|||:||:.|.|| .|||||||
Zfish   163 CSGIRKRRLSNVSLTGLTNTRSISAEPSPSTSDEALLSPVSPSMEQKTPSDIFPGR-GRSNSQSY 226

Human   261 IGRPIHLDKILMSKVKVPHTFVIHSYTRPTVCQYCKKLLKGLFRQGLQCKDCRFNCHKRCAPKVP 325
            |||||.|||||:|||||||||||||||||||||:||||||||||||||||||:||||||||||||
Zfish   227 IGRPIELDKILLSKVKVPHTFVIHSYTRPTVCQHCKKLLKGLFRQGLQCKDCKFNCHKRCAPKVP 291

Human   326 NNCLGEVTINGDLLSPGAESDVVMEEGSDDNDSERNSGLMDDMEEAMVQDAEMAMAECQNDSGEM 390
            |||||||:.||||||||||||||||||.||:|.:|:|.|:|||||::|.|:...:.....:.|:.
Zfish   292 NNCLGEVSRNGDLLSPGAESDVVMEEGCDDHDGDRHSPLIDDMEESLVGDSAAYLEAGHGELGDF 356

Human   391 QDPDPDHEDANRTISPSTSNNIPLMRVVQSVKHTKRKSSTVMKEGWMVHYTSKDTLRKRHYWRLD 455
            ||.|||  ::||.||||||||||||||||||||||||||.||||||:||:|||||||||||||||
Zfish   357 QDLDPD--ESNRIISPSTSNNIPLMRVVQSVKHTKRKSSNVMKEGWLVHFTSKDTLRKRHYWRLD 419

Human   456 SKCITLFQNDTGSRYYKEIPLSEILSLEPVKTSALIPNGANPHCFEITTANVVYYVGENV--VNP 518
            |||||||||||||:|||||||||:|||||.||..|:|.|||||||||.|.::|||||||:  .:.
Zfish   420 SKCITLFQNDTGSKYYKEIPLSEVLSLEPAKTFNLLPEGANPHCFEIATTSLVYYVGENLSRADG 484

Human   519 SSPSPNNSVLTSGVGADVARMWEIAIQHALMPVIPKGSSVGTGTNLHRDISVSISVSNCQIQENV 583
            .|....:|:|.||||.|||.|||:.|||||||||.||.|.|...|.|:::|:|||||||||||||
Zfish   485 GSSGYGSSMLVSGVGQDVAHMWEMVIQHALMPVIAKGISQGGHHNYHKEVSISISVSNCQIQENV 549

Human   584 DISTVYQIFPDEVLGSGQFGIVYGGKHRKTGRDVAIKIIDKLRFPTKQESQLRNEVAILQNLHHP 648
            |||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
Zfish   550 DISTVYQIFPDEVLGSGQFGIVYGGKHRKTGRDVAIKIIDKLRFPTKQESQLRNEVAILQNLHHP 614

Human   649 GVVNLECMFETPERVFVVMEKLHGDMLEMILSSEKGRLPEHITKFLITQILVALRHLHFKNIVHC 713
            |:||||||||||||||||||||||||||||||||||||||.|||||::|||||||||||||||||
Zfish   615 GIVNLECMFETPERVFVVMEKLHGDMLEMILSSEKGRLPERITKFLVSQILVALRHLHFKNIVHC 679

Human   714 DLKPENVLLASADPFPQVKLCDFGFARIIGEKSFRRSVVGTPAYLAPEVLRNKGYNRSLDMWSVG 778
            |||||||||||||.|||||||||||||||||||||||||||||||||||||||||||||||||||
Zfish   680 DLKPENVLLASADSFPQVKLCDFGFARIIGEKSFRRSVVGTPAYLAPEVLRNKGYNRSLDMWSVG 744

Human   779 VIIYVSLSGTFPFNEDEDIHDQIQNAAFMYPPNPWKEISHEAIDLINNLLQVKMRKRYSVDKTLS 843
            ||||||||||||||||||||||||||||||||||||.::.||||||||||||||||||||||:||
Zfish   745 VIIYVSLSGTFPFNEDEDIHDQIQNAAFMYPPNPWKTVTPEAIDLINNLLQVKMRKRYSVDKSLS 809

Human   844 HPWLQDYQTWLDLRELECKIGERYITHESDDLRWEKYAGEQGLQYPTHLINPSASHSDTPETEET 908
            ||||||||.|||||.||||:.||||||||||||||.:|.:.|||||.||:||.|...:..|.:|.
Zfish   810 HPWLQDYQMWLDLRTLECKMLERYITHESDDLRWEHFAEQNGLQYPAHLMNPHADVRELEEPDEL 874

Human   909 EMKALGERVSIL 920
            .|..|.:|||:|
Zfish   875 VMGRLSDRVSVL 886

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
PRKD1	NP_001316998.1	C1_1	147..196	CDD:278556	48/48 (100%)
		C1	279..328	CDD:237996	46/48 (96%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	385..410		13/24 (54%)
		PH_PKD	424..551	CDD:269945	96/128 (75%)
		STKc_PKD	587..846	CDD:270984	248/258 (96%)
		S_TKc	595..847	CDD:214567	241/251 (96%)
prkd1	XP_005158873.1	C1_1	114..163	CDD:278556	48/48 (100%)
		C1	245..294	CDD:237996	46/48 (96%)
		PH_PKD	388..517	CDD:269945	96/128 (75%)
		STKc_PKD	553..812	CDD:270984	248/258 (96%)
		S_TKc	561..813	CDD:214567	241/251 (96%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C194343300
Domainoid	1	1.000	498	1.000	Domainoid score	I2794
eggNOG	1	0.900	-	-		E1_KOG4236
Hieranoid	0	0.000	Not matched by this tool.
Homologene	1	1.000	-	-		H55680
Inparanoid	1	1.050	1459	1.000	Inparanoid score	I1019
NCBI	1	1.000	-	-
OMA	1	1.010	-	-		QHG48438
OrthoDB	1	1.010	-	-		D182843at33208
OrthoFinder	1	1.000	-	-		FOG0002280
OrthoInspector	1	1.000	-	-		oto42577
orthoMCL	1	0.900	-	-		OOG6_103473
Panther	1	1.100	-	-	LDO	PTHR22968
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	1	1.000	-	-		X1509
SwiftOrtho	1	1.000	-	-
TreeFam	1	0.960	-	-
ZFIN	1	1.500	-	-
	17	17.270