DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment SLC22A11 and CG33233

DIOPT Version :9

Sequence 1:	NP_060954.1	Gene:	SLC22A11 / 55867	HGNCID:	18120	Length:	550	Species:	Homo sapiens
Sequence 2:	NP_995978.2	Gene:	CG33233 / 2769005	FlyBaseID:	FBgn0053233	Length:	489	Species:	Drosophila melanogaster

Alignment Length:	468	Identity:	98/468 - (20%)
Similarity:	183/468 - (39%)	Gaps:	136/468 - (29%)

- Green bases have known domain annotations that are detailed below.

Human   114 VDGWVYDRSVFTSTIVAKWDLVCSSQGL------KPLSQSIFMSGILVGSFIWGLLSYRFGRKPM 172
            |..::|..|| |.::.|.:.:|.:|...      |.|..:..:.|::......|.|:.|:|||
  Fly    25 VSFFIYMYSV-TESMTAGYLVVLTSCEFDTSPKEKTLLANSLLGGMVASGLFIGFLADRYGRK-- 86

Human   173 LSWCCLQLAVAGT---STIFA--PTFVIYCGLRFVAAFGMAGIFLSSLTLM----------VEWT 222
               ..::||:.|.   |.|.|  |.......:|.:     .|.|||::..:          ::|
  Fly    87 ---FVIRLALVGALSFSVISALMPDLYSLSVIRII-----VGTFLSAVASLQVGFLGEFHAIKW- 142

Human   223 TTSRRAVTMTVVGCAFSAGQA-------ALGGL----------AFALRDWRTLQLAASVPFFAIS 270
                |.:|:.:  |:.|.|.|       |:..|          ::.||.||.|.:     ||
  Fly   143 ----RPITVAI--CSQSQGLALIYCPLVAMAILPNNFNVDLSSSYNLRVWRFLMM-----FF--- 193

Human   271 LISWWL--------PESARWLIIKGKPDQALQELRKVARINGHK-EAKNLTIEVLMSSVKEEVAS 326
            :|..||        ||:..:|:...:||:||..|:.:.|:|..| |..::|:....||..::...
  Fly   194 MIPGWLALVGICLVPETPHFLMSVNRPDKALLALKWICRMNRKKWEDVDITLSEEKSSTNDQEGF 258

Human   327 AK----EPRSVLDLFCVP-VLRWRSCAMLVVNFSLLISYYGL------VFDLQSLGRDIF----- 375
            .|    |.:.   ||..| |.::..|..|:  |.:..:..||      :.::.:.|.:..
  Fly   259 WKTVWYEYKL---LFSKPHVFKFFICLFLI--FGIFFTSIGLGIWFPVIRNMDNSGSNRLCDLVN 318

Human   376 -----------------------------LLQALFGAVDFLGRATTA-LLLSFLGRRTIQAGSQA 410
                                         |:..::....::|....| :|:.::.|:.:.|
  Fly   319 NNPTFINHEADDTNGTDSESPKCNDEMTNLIDPVYYGFTYIGCFILASVLVHWMTRKYVIA---- 379

Human   411 MAGLAILANMLVPQDLQ-----TLRVVFAVLGKGCFGISLTCLTIYKAELFPTPVRMTADGILHT 470
               |.||.:|::...|.     |:.::|.||.....|:.:...|....:..|..:|..|..::.:
  Fly   380 ---LHILISMILGISLNIMKQPTVVLIFFVLMMVLPGVLIPLATSVLVDCLPVNLRGKALCMVRS 441

Human   471 VGRLGAMMGPLIL 483
            :.|.|.::|..::
  Fly   442 LARFGGVLGSTMI 454

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
SLC22A11	NP_060954.1	Sugar_tr	11..523	CDD:331684	98/468 (21%)
SLC22A11	NP_060954.1	Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	531..550
CG33233	NP_995978.2	MFS_1	22..451	CDD:284993	97/463 (21%)
		MFS	23..>208	CDD:119392	48/208 (23%)
		MFS	354..>482	CDD:304372	22/108 (20%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C165153199
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	2	1.840