DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment sp3a and mamo

DIOPT Version :9

Sequence 1:	XP_005167474.1	Gene:	sp3a / 558652	ZFINID:	ZDB-GENE-070410-111	Length:	691	Species:	Danio rerio
Sequence 2:	NP_572932.2	Gene:	mamo / 32353	FlyBaseID:	FBgn0267033	Length:	1553	Species:	Drosophila melanogaster

Alignment Length:	800	Identity:	170/800 - (21%)
Similarity:	252/800 - (31%)	Gaps:	306/800 - (38%)

- Green bases have known domain annotations that are detailed below.

Zfish    16 SSSAQDGGGAEQDGQPSPLALLAATCTGL-GSPAPGAE-------------------NGASSN-- 58
            |...|....|:|..||.......:...|| |||..||.                   .||.|:
  Fly   854 SGDTQYNKHAQQPQQPQTGGATGSGVGGLGGSPTAGASFNLRYPTPTAFYQQQQQQGKGAKSSPS 918

Zfish    59 ---NASAGVNADLSDQLTSSTERWEAVRDDSGVLHLPGTGIVTSNGQYVLPLQSL-QGLQNQ--- 116
               .|::......:|....|.:|..|..|:..::.||      |.....|..:|| |.||.|
  Fly   919 PQQMATSSTTVMSNDSGEDSCKRSSADSDEVTIMELP------SERSAQLYKESLEQLLQRQRRT 977

Zfish   117 PILLTSGTDASAGAVPNIQYQVIPQVQTTDGQLGFSGASMAQDATG---HIQILPDGTQTISVTS 178
            |||..||:.:.:|.                     ...|:..||.|   :.|:|..|..:...:.
  Fly   978 PILAGSGSGSGSGT---------------------GSGSVIVDAAGLRQYTQLLLAGAGSGGASD 1021

Zfish   179 ADVLSNSQS------LMTQTGQVHQIPQV---------SLGSSAFGGQVTNVPLGLPG------- 221
            ....|:|.|      |:||     |:.|:         ||.||:.||..:..| |:.|
  Fly  1022 LKEKSSSSSTSSTPPLLTQ-----QLSQMLKSPSDTCSSLFSSSGGGTGSTGP-GITGETIEEET 1080

Zfish   222 -----NITF---------------------------------------------------VPINS 230
                 |..|                                                   :|.:.
  Fly  1081 RCVVCNAHFPNVWLLEQHAALQHPHVGPGEEKPFICEQCGQSYRYRSAYAKHKEQNHRARLPADK 1145

Zfish   231 V-----------------------------------DLDSLGLSGAQPIA----------TGITA 250
            :                                   .:..||.||:.|.:          |.::|
  Fly  1146 LFTCDVCGMQFRYLKSFKKHRLNHALERLHGKKSVGVIGRLGGSGSGPSSSAISVSVAAPTSVSA 1210

Zfish   251 DGQLIMTNQSVENSEK------AGEQQQQTLSTNATADMFVPTTSSVSS--------SQATTIDG 301
            .|.:...:|.|..|.:      .||..:..:....|||     ..|..|        .|..|:|.
  Fly  1211 SGSVTSVDQDVVTSSQEPMLADEGEDLRVNVKREGTAD-----EQSAESRANDLEEHEQDNTVDS 1270

Zfish   302 TGVLTQQPVAGEQTDSSGYLSQGAVQVSGGQQVIQLQQLPLQSADGQASAQAQQTMQNIQLINPG 366
            .|:    .:..:..:||...|..|.:.:            :.|:||..|...:..:.:::
  Fly  1271 AGI----TMLYQDNNSSASASTSATEPN------------ISSSDGIHSTNKRSRLHHLE----- 1314

Zfish   367 TFLIQAQTVTPS----------GQIQWQTFQVQGVQNLQNLQLQTAPTQ--QITLAPVQTLSLGQ 419
                    ..||          ...|.|..|.|...:....||   ||.  .::|..|.|.:.|.
  Fly  1315 --------TDPSYPHHHHHHHHHHHQQQHHQAQHQHHNPQSQL---PTHLGHVSLPLVATSAAGS 1368

Zfish   420 GGTPVS----------LSSGQ---------MPNLQSVTVNTVGQAGIQFQQSEDTDSTGDIQIKE 465
            ..:..:          :|||.         .|.  |..|.:.|.:|.....|..:..|..|..:.
  Fly  1369 SSSAAAAAVVAAAQAQVSSGATGSGATGSGAPG--SGNVGSAGSSGAGGGISSLSSLTSLINAER 1431

Zfish   466 EPDSEEWPLDSSSTLNANDLSHLRVRLVEEEMEALSQEGKRLRRVACTCPNCKEGGGRGSNMGKK 530
            .|:.:...|:..   .|:.|:.|||...|.      |..||.......||
  Fly  1432 IPNEQFLGLNPQ---EASILNFLRVDAAER------QRDKRPATSRFACP--------------- 1472

Zfish   531 KQHVCHIAGCGKVYGKTSHLRAHLRWHSGERPFVCTWMFCGKRFTRSDELQRHRRTHTGEKKFVC 595
                    .|||......:|:.|:|.|:|||||||  :|||:.|....:|.||.|.||||:.:.|
  Fly  1473 --------FCGKCVRSKENLKLHVRKHTGERPFVC--LFCGRAFGGKSDLTRHLRIHTGERPYHC 1527

Zfish   596 SECSKRFMRSDHLAKHIKTH 615
            ..|.|.|.|:|:|:||:.||
  Fly  1528 ESCGKCFARADYLSKHLTTH 1547

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
sp3a	XP_005167474.1	Fimbrial	125..230	CDD:294848	28/185 (15%)
		zf-C2H2	533..557	CDD:278523	6/23 (26%)
		C2H2 Zn finger	535..557	CDD:275368	6/21 (29%)
		COG5048	<548..619	CDD:227381	33/67 (49%)
		zf-H2C2_2	549..576	CDD:290200	15/26 (58%)
		C2H2 Zn finger	565..587	CDD:275368	9/21 (43%)
		zf-H2C2_2	579..602	CDD:290200	11/22 (50%)
		zf-C2H2	593..615	CDD:278523	9/21 (43%)
		C2H2 Zn finger	595..615	CDD:275368	9/19 (47%)
mamo	NP_572932.2	BTB	21..118	CDD:279045
		BTB	32..118	CDD:197585
		C2H2 Zn finger	1082..1105	CDD:275368	2/22 (9%)
		C2H2 Zn finger	1116..1137	CDD:275368	0/20 (0%)
		C2H2 Zn finger	1149..1169	CDD:275368	0/19 (0%)
		zf-C2H2	1469..1491	CDD:278523	8/44 (18%)
		C2H2 Zn finger	1471..1491	CDD:275368	8/42 (19%)
		zf-H2C2_2	1483..1506	CDD:290200	14/24 (58%)
		C2H2 Zn finger	1499..1519	CDD:275368	9/21 (43%)
		zf-H2C2_2	1511..1536	CDD:290200	12/24 (50%)
		C2H2 Zn finger	1527..1547	CDD:275368	9/19 (47%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
ZFIN	0	0.000	Not matched by this tool.
	1	0.910