Protein Alignment PKN2 and pkn2

DIOPT Version :9

• Sequence 1: NP_006247.1
• Gene: PKN2 / 5586
• HGNCID: 9406
• Length: 984
• Species: Homo sapiens
• Sequence 2: XP_004913783.1
• Gene: pkn2 / 100488854
• XenbaseID: XB-GENE-995298
• Length: 982
• Species: Xenopus tropicalis
• Alignment Length: 988
• Identity: 838/988 - (84%)
• Similarity: 900/988 - (91%)
• Gaps: 10/988 - (1%)

Human     1 MASNPERGEILLTELQGDSRSLPFSENVSAVQKLDFSDTMVQQKLDDIKDRIKREIRKELKIKEG 65
            ||||.:| ||:||:.| |.||...:|.:....|:||||.:.|..||::||:||||||||||||||
 Frog     1 MASNTDR-EIILTDYQ-DPRSSIVAEPMGIFPKIDFSDPLAQPHLDEMKDQIKREIRKELKIKEG 63

Human    66 AENLRKVTTDKKSLAYVDNILKKSNKKLEELHHKLQELNAHIVVSDPEDITDCPRTPDTPNNDPR 130
            ||||||||||||:|||||||||||||||||||:.|||||||||:.:.|::.|||:|||||.:|..
 Frog    64 AENLRKVTTDKKNLAYVDNILKKSNKKLEELHNNLQELNAHIVMREAENLPDCPKTPDTPKSDSG 128

Human   131 CSTSNNRLKALQKQLDIELKVKQGAENMIQMYSNGSSKDRKLHGTAQQLLQDSKTKIEVIRMQIL 195
            .|..|.||.|||||||||||||||||||||.||||.||||||.|||||:||||||||||||||||
 Frog   129 SSAFNGRLIALQKQLDIELKVKQGAENMIQTYSNGPSKDRKLLGTAQQMLQDSKTKIEVIRMQIL 193

Human   196 QA-VQTNELAFDNAKPVISPLELRMEELRHHFRIEFAVAEGAKNVMKLLGSGKVTDRKALSEAQA 259
            || .||||::|||||||||||||||||||||.||||||.||||||||||||||||||||||||.:
 Frog   194 QANQQTNEMSFDNAKPVISPLELRMEELRHHVRIEFAVTEGAKNVMKLLGSGKVTDRKALSEAHS 258

Human   260 RFNESSQKLDLLKYSLEQRLNEVPKNHPKSRIIIEELSLVAASPTLSPRQSMISTQNQYSTLSKP 324
            ||||||||||||||||||||:|:|||||||.:|||||||| ||||||||||||||||||||||||
 Frog   259 RFNESSQKLDLLKYSLEQRLSELPKNHPKSSVIIEELSLV-ASPTLSPRQSMISTQNQYSTLSKP 322

Human   325 AALTGTLEVRLMGCQDILENVPGRSKATSVALPGWSPSETRSSFMSRTSKSKSGSSRNLLKTDDL 389
            |||||||||||||||||||||||||||.|..||.|||||.||||||||||:|||||||||||::.
 Frog   323 AALTGTLEVRLMGCQDILENVPGRSKAASATLPAWSPSEARSSFMSRTSKNKSGSSRNLLKTEEF 387

Human   390 SNDVCAVLKLDNTVVGQTSWKPISNQSWDQKFTLELDRSRELEISVYWRDWRSLCAVKFLRLEDF 454
            ||:|||:|||||||||||:|||||||||||||||||||||||||||:||||||||||||||||||
 Frog   388 SNEVCAMLKLDNTVVGQTNWKPISNQSWDQKFTLELDRSRELEISVFWRDWRSLCAVKFLRLEDF 452

Human   455 LDNQRHGMCLYLEPQGTLFAEVTFFNPVIERRPKLQRQKKIFSKQQGKTFLRAPQMNINIATWGR 519
            |||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
 Frog   453 LDNQRHGMCLYLEPQGTLFAEVTFFNPVIERRPKLQRQKKIFSKQQGKTFLRAPQMNINIATWGR 517

Human   520 LVRRAIPTVNHSGTFSPQAPVPTTVPVVDVRIPQLAPPASDSTVTKLDFDLEPEPPPAPPRASSL 584
            ||||||||||||||:|||..||..|||||.|..:|: |.|:|||.|||||||||.||||||:|||
 Frog   518 LVRRAIPTVNHSGTYSPQVAVPAAVPVVDPRNLELS-PISESTVAKLDFDLEPEAPPAPPRSSSL 581

Human   585 GEI-DESSELRVLDIPGQDSETVFDIQNDRNSILPKSQSE--YKPDTPQSGLEYSGIQELEDRRS 646
            |:: ..|:|.:..::|..|  |.::..|:|.|::.|..:|  .:|:.|.|.:.||.|:|.||||.
 Frog   582 GDLYQPSAEHKAPNVPVPD--TNYENSNNRISVIAKPTAEVTIEPEIPVSDMNYSTIEESEDRRI 644

Human   647 QQRFQFNLQDFRCCAVLGRGHFGKVLLAEYKNTNEMFAIKALKKGDIVARDEVDSLMCEKRIFET 711
            ||||||:||||.|||||||||||||||||||:|||||||||||||||||||||||||||||||||
 Frog   645 QQRFQFSLQDFHCCAVLGRGHFGKVLLAEYKSTNEMFAIKALKKGDIVARDEVDSLMCEKRIFET 709

Human   712 VNSVRHPFLVNLFACFQTKEHVCFVMEYAAGGDLMMHIHTDVFSEPRAVFYAACVVLGLQYLHEH 776
            |||||||||||||||||||:|||||||||||||||||||||||||||||||||||||||||||||
 Frog   710 VNSVRHPFLVNLFACFQTKDHVCFVMEYAAGGDLMMHIHTDVFSEPRAVFYAACVVLGLQYLHEH 774

Human   777 KIVYRDLKLDNLLLDTEGFVKIADFGLCKEGMGYGDRTSTFCGTPEFLAPEVLTETSYTRAVDWW 841
            |||||||||||||||||||||||||||||||||:|||||||||||||||||||||||||||||||
 Frog   775 KIVYRDLKLDNLLLDTEGFVKIADFGLCKEGMGFGDRTSTFCGTPEFLAPEVLTETSYTRAVDWW 839

Human   842 GLGVLIYEMLVGESPFPGDDEEEVFDSIVNDEVRYPRFLSTEAISIMRRLLRRNPERRLGASEKD 906
            |||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
 Frog   840 GLGVLIYEMLVGESPFPGDDEEEVFDSIVNDEVRYPRFLSTEAISIMRRLLRRNPERRLGASEKD 904

Human   907 AEDVKKHPFFRLIDWSALMDKKVKPPFIPTIRGREDVSNFDDEFTSEAPILTPPREPRILSEEEQ 971
            |||||||||||..||:||:.|||||||:|||:||||||||||||||||||||||||||||:||||
 Frog   905 AEDVKKHPFFRHTDWNALLAKKVKPPFVPTIKGREDVSNFDDEFTSEAPILTPPREPRILTEEEQ 969

Human   972 EMFRDFDYIADWC 984
            |.|||||||||||
 Frog   970 EAFRDFDYIADWC 982

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
PKN2	NP_006247.1	HR1_PKN_1	42..107	CDD:212012	56/64 (88%)
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	114..133		9/18 (50%)
		HR1	130..201	CDD:294066	59/71 (83%)
		HR1_PKN2_3	209..282	CDD:212025	67/72 (93%)
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	351..383		25/31 (81%)
		Necessary to rescue apical junction formation. /evidence=ECO:0000250	382..463		73/80 (91%)
		C2_PKN-like	390..473	CDD:176069	78/82 (95%)
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	558..584		20/25 (80%)
		STKc_PKN	657..982	CDD:270741	311/324 (96%)
		S_TKc	662..916	CDD:214567	250/253 (99%)
		Necessary for the catalytic activity	917..977		50/59 (85%)
		Negatively regulates the responsiveness of the catalytic activity by cardiolipin and is required for optimal activation by the GTP-bound RhoA	978..984		5/5 (100%)
pkn2	XP_004913783.1	HR1_PKN_1	40..105	CDD:212012	56/64 (88%)
		HR1	129..197	CDD:381797	58/67 (87%)
		HR1	208..281	CDD:381797	67/72 (93%)
		C2_PKN-like	390..471	CDD:176069	76/80 (95%)
		STKc_PKN	655..980	CDD:270741	311/324 (96%)

Information from Original Tools

Tool	Simple Score	Weighted Score	Original Tool Information
			BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	1	1.000	599	1.000	Domainoid score	I2447
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	1	1.000	-	-
Homologene	1	1.000	-	-		H2054
Inparanoid	1	1.050	1649	1.000	Inparanoid score	I1113
NCBI	1	1.000	-	-
OMA	1	1.010	-	-		QHG49182
OrthoDB	1	1.010	-	-		D241576at33208
OrthoFinder	1	1.000	-	-		FOG0001458
OrthoInspector	1	1.000	-	-		oto155939
Panther	1	1.100	-	-	LDO	PTHR24356
Phylome	1	0.910	-	-
RoundUp	1	1.030	-	avgDist	Average_Evolutionary_Distance	R891
SonicParanoid	1	1.000	-	-		X914
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	13	13.110