DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment lrit3a and DIP-delta

DIOPT Version :9

Sequence 1:	NP_001122166.1	Gene:	lrit3a / 558559	ZFINID:	ZDB-GENE-080723-63	Length:	636	Species:	Danio rerio
Sequence 2:	NP_001097508.2	Gene:	DIP-delta / 5740816	FlyBaseID:	FBgn0085420	Length:	469	Species:	Drosophila melanogaster

Alignment Length:	508	Identity:	94/508 - (18%)
Similarity:	177/508 - (34%)	Gaps:	121/508 - (23%)

- Green bases have known domain annotations that are detailed below.

Zfish    78 YYLSELRYLWITYNSITSVDPGSFYNLKVLHELRLDGNMIATFPWES---LKEMPSLKTLDLHNN 139
            :.|:.::.|.|..|    :.|..|.|.:::..:.:. |::.....:.   .:.:|::......:.
  Fly     2 FILTVVKLLLIALN----IFPSRFTNRRIMFLIYMT-NLVTHVMMDEPRFAQPIPNVTVAVGRDA 61

Zfish   140 RLTSVPVEAAPYLINITYLDISSNKLTTLPSDLVDIWPPFSGIQPSANTSQKTV-LGLQDNPWYC 203
            .|..|......|  .:.::.|....:.|:...::...|.:| |..:.||....| ...||:..|.
  Fly    62 NLPCVVEHLGGY--KVAWIHIDRQMILTIHRHVISRIPRYS-ITYTDNTWLLHVNQAHQDDRGYY 123

Zfish   204 DCRISKLIELSKMAGIPVVLMDQVLTCSGPEHLSGVLFQRAELDQCVKPTVMTSATKITSPLGSN 268
            .|:::....:|::..:.||:...:|                        .:.::.:.:......|
  Fly   124 MCQVNTNPMISQVGYLQVVVPPNIL------------------------DIESTPSSVAVRENQN 164

Zfish   269 VLLRCDANGFPTPTLLWTTADGSVV-----NNTVVQESPGEGVRWSILSLHSIVFKDAGDYRCKA 328
            :.:.|.|:|||.|.::|...||..:     ...:|.::       .:|.|..:...:.|.|.|.|
  Fly   165 INMTCRADGFPAPKIIWRREDGEEIAVEKKKKVLVYDA-------DVLPLTKVSRNEMGAYLCIA 222

Zfish   329 KN-VAGNAEAYITLSVDGVQPTTPFPP-INITKQPEDQPTTTFTPTKMPLFTSLSPITI---TTR 388
            .| |..:....|.|.|:       |.| |.:..|....|:.  |...:...|...|..|   ...
  Fly   223 TNGVPPSVSKRIILDVE-------FSPMIWVPNQLVGAPSG--TDVTIDCHTEAHPKAIIYWVYN 278

Zfish   389 PVMTTMPPLTTRKSPIPGGGVQRSPPAGDKPAKVQQSKNGKGSIKKSDIRDIEVVE--------- 444
            .||.           :|           .|..|...::|...:..|..||:::..:
  Fly   279 SVMV-----------LP-----------SKKYKTDYTENSYRAHMKLTIRNLQYGDFGNYRCISK 321

Zfish   445 ---ETTETAVLLWSAEGLPSDTPLTVVY----------FPYDAKDDKETVDTEVGQGKLLLEYLM 496
               ..||.::.::... |||.....|.:          .|....|..:::.|:||       |.|
  Fly   322 NSLGETEGSIRVYEIP-LPSTPSKQVTHTTVESRENNIIPSSRNDTTKSLQTDVG-------YAM 378

Zfish   497 PNQVYTVCLVTKSSGKEQCVDFSTLEI------GGEEGQNKVLMIASAIACAI 543
            .|.:|.....:.|||.......|:..:      ||..| |.:..:.|..:.||
  Fly   379 KNDLYPGSASSSSSGGSSSAASSSSSMQTSALPGGVAG-NSLSSMGSKGSLAI 430

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
lrit3a	NP_001122166.1	LRR_8	81..141	CDD:290566	8/62 (13%)
		leucine-rich repeat	83..106	CDD:275378	6/22 (27%)
		LRR_4	107..145	CDD:289563	3/40 (8%)
		leucine-rich repeat	107..130	CDD:275378	1/25 (4%)
		LRR_8	129..>171	CDD:290566	6/41 (15%)
		LRR_4	129..170	CDD:289563	6/40 (15%)
		leucine-rich repeat	131..154	CDD:275378	3/22 (14%)
		leucine-rich repeat	155..168	CDD:275378	1/12 (8%)
		TPKR_C2	199..249	CDD:301599	6/49 (12%)
		Ig	252..343	CDD:299845	21/96 (22%)
		IG_like	261..343	CDD:214653	21/87 (24%)
DIP-delta	NP_001097508.2	IG	51..143	CDD:214652	18/94 (19%)
		Ig	145..238	CDD:416386	22/123 (18%)
		Ig strand A	145..149	CDD:409353	1/27 (4%)
		Ig strand A'	154..159	CDD:409353	0/4 (0%)
		Ig strand B	165..172	CDD:409353	1/6 (17%)
		Ig strand C	178..183	CDD:409353	1/4 (25%)
		Ig strand C'	185..187	CDD:409353	1/1 (100%)
		Ig strand D	195..199	CDD:409353	0/3 (0%)
		Ig strand E	203..209	CDD:409353	2/5 (40%)
		Ig strand F	216..223	CDD:409353	3/6 (50%)
		Ig strand G	230..238	CDD:409353	2/7 (29%)
		Ig	242..333	CDD:416386	19/114 (17%)
		Ig strand A'	250..253	CDD:409353	0/2 (0%)
		Ig strand B	259..266	CDD:409353	0/6 (0%)
		Ig strand C	272..277	CDD:409353	1/4 (25%)
		Ig strand C'	281..283	CDD:409353	1/12 (8%)
		Ig strand D	289..293	CDD:409353	1/3 (33%)
		Ig strand E	295..305	CDD:409353	2/9 (22%)
		Ig strand F	314..322	CDD:409353	0/7 (0%)
		Ig strand G	325..334	CDD:409353	2/8 (25%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_KOG3510
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
ZFIN	0	0.000	Not matched by this tool.
	1	0.900