DRSC/TRiP Functional Genomics Resources

powered by:
logo

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits


Protein Alignment PKN1 and PKC1

DIOPT Version :9

Sequence 1:NP_998725.1 Gene:PKN1 / 5585 HGNCID:9405 Length:948 Species:Homo sapiens
Sequence 2:NP_009445.2 Gene:PKC1 / 852169 SGDID:S000000201 Length:1151 Species:Saccharomyces cerevisiae


Alignment Length:1226 Identity:284/1226 - (23%)
Similarity:445/1226 - (36%) Gaps:508/1226 - (41%)


- Green bases have known domain annotations that are detailed below.


Human   137 LEKQLAIELKVKQGAENM---------IQTYSNGSTKDRKLLLTAQQMLQDSKTKIDIIRMQLRR 192
            ::|::|:|..:.:||..:         ||..:....:.|:.|    :.|:||..|:.:      :
Yeast    10 IKKKIAVEENIIRGASALKKKTSNVMVIQKCNTNIREARQNL----EYLEDSLKKLRL------K 64

Human   193 ALQAGQLENQAAPDDTQGSPDLG---------------------------AVELRIEELRHHFRV 230
            ..|..|.||.:..::...|.:.|                           .::..:::|....:|
Yeast    65 TAQQSQGE
NGSEDNERCNSKEYGFLSTKSPNEHIFSRLDLVKYDCPSLAQRIQYMLQQLEFKLQV 129

Human   231 EHAVAEGAKNVLRLLSAAKAPDRKAVSEAQEKLTESNQKLGLLREALER---------RLGELPA 286
            |....|....:.:|...  ..|:::.|.|:....||..::.:|.:||::         :....|.
Yeast   130 EKQYQEANTKLTKLYQI--DGDQRSSSAAEGGAMESKYRIQMLNKALKKYQAINVDFDQFKHQPN 192

Human   287 D-----HPKGRLLREELAAASSAAFSTRLAGPFPATHYSTLCKPAPLTGTLEVRVVGCRDLPETI 346
            |     .||.|  |::                              |||.|.:.:...||:... 
Yeast   193 DIMDNQQPKFR--RKQ------------------------------LTGVLTIGITAARDVDHI- 224

Human   347 PWNPTPSMGGPGTPDSRPPFLSRPARGLYSRSGSLSGRSSLKAEAENTSEVSTVLKLDNTVVGQT 411
                           ..|.|..:|                         |....:|:|:|:..:|
Yeast   225 ---------------QSPMFARKP-------------------------ESYVTIKIDDTIKART 249

Human   412 SWKPCGPNAWDQSFTLELERARELELAVFWRDQRGL--CALKFLKLEDFLD----------NERH 464
              ||...:.|.:.|.:.:|:..|:|:.|:.:....|  .|:.:|.|.|..:          ||:.
Yeast   250 --KPSRNDRWSEDFQIPVEKGNEIEITVYDKVNDSLIPVAIMWLLLSDIAEEIRKKKAGQTNEQQ 312

Human   465 -------------------------------------EVQLD--------------MEPQGCLVA 478
                                                 .||.:              :||.|.::.
Yeast   313 GWVNASNINGGSSLASEEGSTLTSTYSNSAIQSTSAKNVQGENTSTSQISTNSWFVLEPSGQILL 377

Human   479 EVTF-RNPVIER------IPR----LRRQKKIFSKQQGKAFQRARQMNI---------------- 516
            .:.| ::..|||      :.|    :.|:::|| :|.|..|.:....||                
Yeast   378 TLGFHKSSQIERKQLMGGLHRHGAIINRKEEIF-EQHGHHFVQKSFYNIMCCAYCGDFLRYTGFQ 441

Human   517 --------------DVAT--------------------------------------------WVR 523
                          :|.|                                            |.|
Yeast   442 CQDCKFLCHKKCYTNVVTKCIAKTSTDTDPDEAKLNHRIPHRFLPTSNRGTKWCCHCGYILPWGR 506

Human   524 LLRR---------------LIPNATGTG---------TFS-------------PGASPGSEARTT 551
            ...|               |:|:..|..         |..             |.|..||...|.
Yeast   507 HKVRKCSECGIMCHAQCAHLVPDFCGMSMEMANKILKTIQDTKRNQEKKKRTVPSAQLGSSIGTA 571

Human   552 --GDISVEKLNLGT-----------DSDSSPQKSSRDPP-------------------------- 577
              .|:|..||....           |...||||..||.|                          
Yeast   572 NGSDLSPSKLAERANAPLPPQPRKHDKTPSPQKVGRDSPTKQHDPIIDKRISLQTHGREKLNKFI 636

Human   578 -------------------SSPSSLSSP------------------------------------- 586
                               |||.....|                                     
Yeast   637 DENEAYLNFTEGAQQTAEFSSPEKTLDPTSNRRSLGLTDLSIEHSQTWESKDDLMRDELELWKAQ 701

Human   587 --------------IQES---------------------------------TAP--ELPSET--- 599
                          |||.                                 |.|  ::.|||   
Yeast   702 REEMELEIKQDSGEIQEDLEVDHIDLETKQKLDWENKNDFREADLTIDSTHTNPFRDMNSETFQI 766

Human   600 ----------------------------QETPGPALCS--------PLRKSPLTLEDFKFLAVLG 628
                                        |::|..:..|        ..::..::|::|..|.|||
Yeast   767 EQDHASKEVLQETVSLAPTSTHASRTTDQQSPQKSQTSTSAKHKKRAAKRRKVSLDNFVLLKVLG 831

Human   629 RGHFGKVLLSEFRPSGELFAIKALKKGDIVARDEVESLMCEKRILAAVTSAGHPFLVNLFGCFQT 693
            :|:||||:||:.:.:..|.|||.|||.:|:...::||...||::....|...||||.||:..|||
Yeast   832 KGNFGKVILSKSKNTDRLCAIKVLKKDNIIQNHDIESARAEKKVFLLATKTKHPFLTNLYCSFQT 896

Human   694 PEHVCFVMEYSAGGDLMLHIHSDVFSEPRAIFYSACVVLGLQFLHEHKIVYRDLKLDNLLLDTEG 758
            ...:.|.||:..|||||.|:.:...|..||.||:|.|:|.|::.|::.::||||||:|:||..||
Yeast   897 ENRIYFAMEFIGGGDLMWHVQNQRLSVRRAKFYAAEVLLALKYFHDNGVIYRDLKLENILLTPEG 961

Human   759 YVKIADFGLCKEGMGYGDRTSTFCGTPEFLAPEVLTDTSYTRAVDWWGLGVLLYEMLVGESPFPG 823
            ::||||:||||:.|.||:|||||||||||:|||:|.:..||:|||||..|||||:||:.:|||.|
Yeast   962 HIKIADYGLCKDEMWYGNRTSTFCGTPEFMAPEILKEQEYTKAVDWWAFGVLLYQMLLCQSPFSG 1026

Human   824 DDEEEVFDSIVNDEVRYPRFLSAEAIGIMRRLLRRNPERRLGSSERDAEDVKKQPFFRTLGWEAL 888
            |||:|||::|:.||..||..::.|.:.|.:.||.::||:|||:..|||::|.::||||.:.::.:
Yeast  1027 DDEDEVFNAILTDEPLYPIDMAGEIVQIFQGLLTKDPEKRLGAGPRDADEVMEEPFFRNINFDDI 1091

Human   889 LARRLPPPFVPTLSGRTDVSNFDEEFTGEAPTLSPPRDARPLTAAEQAAFLDFDFV 944
            |..|:.||::|.:....|.|.|::|||...|||:|....  ||.::|..|..|.|:
Yeast  1092 LNLRVKPPYIPEIKSPEDTSYFEQEFTSAPPTLTPLPSV--LTTSQQEEFRGFSFM 1145

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
PKN1NP_998725.1 HR1_PKN_1 <52..104 CDD:212012
HR1_PKN1_2 127..202 CDD:212020 16/73 (22%)
HR1_PKN1_3 211..284 CDD:212026 15/108 (14%)
C2_PKN-like 395..482 CDD:176069 25/149 (17%)
STKc_PKN 621..945 CDD:270741 157/324 (48%)
S_TKc 621..880 CDD:214567 133/258 (52%)
PKC1NP_009445.2 HR1_PKC-like_1_fungi 1..72 CDD:212011 15/71 (21%)
HR1_PKC-like_2_fungi 110..181 CDD:212010 13/72 (18%)
C2_fungal_Pkc1p 211..319 CDD:176071 26/150 (17%)
C1_ScPKC1-like_rpt1 413..464 CDD:410372 6/50 (12%)
C1_ScPKC1-like_rpt2 478..536 CDD:410373 6/57 (11%)
STKc_PKC 828..1145 CDD:270722 154/318 (48%)
Blue background indicates that the domain is not in the aligned region.


Information from Original Tools:


Tool Simple Score Weighted Score Original Tool Information
BLAST Result Score Score Type Cluster ID
Compara 00.000 Not matched by this tool.
Domainoid 1 1.000 298 1.000 Domainoid score I249
eggNOG 1 0.900 - - E1_KOG0694
Hieranoid 00.000 Not matched by this tool.
Homologene 00.000 Not matched by this tool.
Inparanoid 00.000 Not matched by this tool.
Isobase 00.000 Not matched by this tool.
OMA 00.000 Not matched by this tool.
OrthoFinder 00.000 Not matched by this tool.
OrthoInspector 1 1.000 - - otm53138
orthoMCL 00.000 Not matched by this tool.
Panther 1 1.100 - - O PTHR24356
Phylome 1 0.910 - -
RoundUp 1 1.030 - avgDist Average_Evolutionary_Distance R891
SonicParanoid 00.000 Not matched by this tool.
SwiftOrtho 00.000 Not matched by this tool.
TreeFam 00.000 Not matched by this tool.
65.940

Return to query results.
Submit another query.