DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment PKN1 and Pkcdelta

DIOPT Version :9

Sequence 1:	NP_998725.1	Gene:	PKN1 / 5585	HGNCID:	9405	Length:	948	Species:	Homo sapiens
Sequence 2:	NP_572797.3	Gene:	Pkcdelta / 32191	FlyBaseID:	FBgn0259680	Length:	1894	Species:	Drosophila melanogaster

Alignment Length:	991	Identity:	282/991 - (28%)
Similarity:	427/991 - (43%)	Gaps:	226/991 - (22%)

- Green bases have known domain annotations that are detailed below.

Human   110 AATHDGPQSPGAGGPTCSATNLSRVAG---LEKQLAIELK-VKQGAENMIQTYSNGSTKDRKLLL 170
            |||.:...:|.|...|.:..:::.:||   .|....|..| :||....:....:..:|.:.....
  Fly   965 AATDESKSTPAAPKTTMAKISMTTMAGTTVAEAGKTISPKGLKQSGNAVAMPTATPTTPNTPTTA 1029

Human   171 TAQQMLQDSKTKIDIIRMQLRRALQAGQLEN--QAAPDDTQGSPDLGAVELRI------EELRHH 227
            |.:..|.::                ||...|  |.|....|......|||.:|      |:.:..
  Fly  1030 TGKSKLNET----------------AGPKINSGQPAKSPEQQQATAAAVETKINKTTDKEQQQQQ 1078

Human   228 FRVEHAVAEGAKNVLRLLSAAKAPDRKAVSEAQEKLTESNQKLGLLREALERRLGELPADHPKGR 292
            .:.:...|:..:..|...:|...|.    :|.:.||||:.:..|  :..::......|....|..
  Fly  1079 QQQQQQQAQQQQQQLIDTAATLVPQ----TETKTKLTEAAEPTG--KSKVQSPNTTKPKSAGKTN 1137

Human   293 LLREELAAASSAAFSTRLAGPFPATHYSTLCKPAPLTGTLEVRVVGCRDLPETIPWNPT------ 351
            :.:::.|..::||.:...|.|..||      ....:|...|..|... :..:.|...||
  Fly  1138 VGKKKAATPAAAAAAAAAAAPAAAT------ATEAVTALSESNVTPI-NADQFITLAPTKAAKTS 1195

Human   352 -----------------------------PSMGGPGTPDSRPPFLSRPARGLYSRSGSLSGRSSL 387
                                         |:..|..|  :.|..::.....:...:.::...::.
  Fly  1196 PNKQQALQLQQQHEEQQRQQQQQATNASSPAATGDAT--TTPTTITIGVAAVNVAAVAVVASAAA 1258

Human   388 KAEAENTSEVSTVLKLDNTVVGQTSWKPCGPNAWDQSFTLELER-ARELELAVFWRDQRGLCALK 451
            .|..:..::.:|.|..:|:         ||....:     .|.: |....||...||...
  Fly  1259 AAATDAAADATTSLSSNNS---------CGEGVGN-----NLSKFATVSNLAQCLRDVDA----- 1304

Human   452 FLKLEDFLDNERHEVQLDMEP---------------QGCLVAEVTFRNPVIERIPRLRRQKKIFS 501
              :|:|::.:.....|.|.:.               .||.....:.:.       :||::||
  Fly  1305 --ELDDYIPSSAENSQEDDDDDDDGSGSSSDDYSSVDGCANLSASMKK-------KLRKEKK--- 1357

Human   502 KQQGKA--------FQRARQMNID----------------VAT----WVRLLRRLI------PNA 532
            ||:.||        |...:::.||                |||    |.|  .:::      .:.
  Fly  1358 KQKAKAAAAAEAKRFDPHKKIKIDTTNKCYVKEEAPRYPLVATPRPLWKR--EKIVYSDENTDDE 1420

Human   533 TGTGTFSPGA--------SPGSE-ARTTGDISVEKL------------NLGTDSDSSPQKSSR-- 574
            :|:...|.|:        |.|.| :.|:...|.|.|            |..|..|||....|.
  Fly  1421 SGSEEGSGGSLDEDSDDESGGEECSSTSSSASSEDLDAVAMVTKAGSSNATTVLDSSNSSGSNAG 1485

Human   575 ---------------DPPSSPS-------SLSSPIQESTAPELPSETQET-------------PG 604
                           ...||||       |..|..:..|||..|.:..||             ..
  Fly  1486 TLSVPSAGSGSGGGASTSSSPSIIRMSTCSNDSGFEGGTAPSSPKKMLETSYTYSQFQKSGRFTA 1550

Human   605 PALCSPLRKSPLTLEDFKFLAVLGRGHFGKVLLSEFRPSGELFAIKALKKGDIVARDEVESLMCE 669
            ||...|..|: .:::||.||||||:|.||||||:|.|.:...:|||.|||..::..|:|:|.:.|
  Fly  1551 PATVIPRFKN-YSVDDFHFLAVLGKGSFGKVLLAELRDTTYYYAIKCLKKDVVLEDDDVDSTLIE 1614

Human   670 KRILAAVTSAGHPFLVNLFGCFQTPEHVCFVMEYSAGGDLMLHI-HSDVFSEPRAIFYSACVVLG 733
            :::||..|.  ||:|.:||..|||..|:.|||||..|||||.|| .|..|||.||.||.|.::.|
  Fly  1615 RKVLALGTK--HPYLCHLFCTFQTESHLFFVMEYLNGGDLMFHIQESGRFSEERARFYGAEIISG 1677

Human   734 LQFLHEHKIVYRDLKLDNLLLDTEGYVKIADFGLCKEGMGYGDRTS-TFCGTPEFLAPEVLTDTS 797
            |:|||:..|:||||||||:|||.||:|:|||||:||..: |.|:|: :|||||:::|||::....
  Fly  1678 LKFLHKKGIIYRDLKLDNVLLDYEGHVRIADFGMCKLQI-YLDKTADSFCGTPDYMAPEIIKGEK 1741

Human   798 YTRAVDWWGLGVLLYEMLVGESPFPGDDEEEVFDSIVNDEVRYPRFLSAEAIGIMRRLLRRNPER 862
            |.:.||||..||||||||:|:|||.|.||:|:|.||.|:...:|.::||||.||::.||.::..:
  Fly  1742 YNQNVDWWSFGVLLYEMLIGQSPFSGCDEDELFWSICNEIPWFPVYISAEATGILKGLLEKDYTK 1806

Human   863 RLGSSERDAEDVKKQPFFRTLGWEALLARRLPPPFVPTLSGRTDVSNFDEEFTGEAPTLSPPRDA 927
            |:||....|.|:....|||.:.|..|..|::.|||.|.:....|...||..||.|...|: |.|.
  Fly  1807 RIGSQYSPAGDIADHIFFRPIDWGLLEKRQIEPPFKPQVKHPLDTQYFDRVFTRERVRLT-PIDK 1870

Human   928 RPLTAAEQAAFLDFDF 943
            ..|.:.:|..|..|.:
  Fly  1871 EILASMDQKQFHGFTY 1886

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
PKN1	NP_998725.1	HR1_PKN_1	<52..104	CDD:212012
		HR1_PKN1_2	127..202	CDD:212020	13/80 (16%)
		HR1_PKN1_3	211..284	CDD:212026	15/78 (19%)
		C2_PKN-like	395..482	CDD:176069	17/102 (17%)
		STKc_PKN	621..945	CDD:270741	159/325 (49%)
		S_TKc	621..880	CDD:214567	136/260 (52%)
Pkcdelta	NP_572797.3	S_TKc	1566..1824	CDD:214567	136/260 (52%)
Pkcdelta	NP_572797.3	STKc_nPKC_theta_like	1570..1889	CDD:270744	156/321 (49%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C165149255
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	1	1.030	-	avgDist	Average_Evolutionary_Distance	R891
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	3	2.870