Protein Alignment stard8 and cv-c

DIOPT Version :9

• Sequence 1: NP_001119949.1
• Gene: stard8 / 558476
• ZFINID: ZDB-GENE-030131-9447
• Length: 1076
• Species: Danio rerio
• Sequence 2: NP_001097786.1
• Gene: cv-c / 41749
• FlyBaseID: FBgn0285955
• Length: 2351
• Species: Drosophila melanogaster
• Alignment Length: 1148
• Identity: 391/1148 - (34%)
• Similarity: 574/1148 - (50%)
• Gaps: 208/1148 - (18%)

Zfish     5 CNGQQSRSLTSQLRE-----STFRA--LTL-LRRKAKQRQFAELEAKDACEWLRAAGFPQYAQLY 61
            |....|..:..:.||     ..|.|  ||| ..|....|..||:||.:||:||||||||||||:|
  Fly  1336 CTKSNSAPMLLKEREMSRRFDNFEAQHLTLRYSRSQSDRYLAEIEAVEACKWLRAAGFPQYAQMY 1400

Zfish    62 EASLFPIEISAVRRDHEFLDQDSLKALCRRLTTLNKCAAMSLEVHF--QCKQQSEDSEEDDACAL 124
            |...|||:::.|.:||..|:.|.|::|.|||..||:||.|.|:...  |..||.|:| :|:..||
  Fly  1401 EDHQFPIDLNNVAKDHTNLENDQLQSLYRRLCVLNRCATMRLDQSHKPQTPQQKEES-DDENFAL 1464

Zfish   125 SSRWAFQRESKTWSRLRTLSPTPVSPGNRSSTLRPSGSSDSVLSDISLLEVTSLTSDLSNSSLSL 189
            |..|.||...:.|||:          |.....|.|.|     |..:::.:..|.:.:.|......
  Fly  1465 SEHWTFQPHIRRWSRI----------GEMGLELPPPG-----LLSLNVEKTESSSKESSPDRFEE 1514

Zfish   190 DSARET-TSPEVVPFSGV-NEGASSVFVSASKDENDDTGSSSSLPSVREKPKRPSRSFLRRKESV 252
            |.|..| .:|......|: |:|       :|..|..|:|....  |..|:.|..:::.|||.||:
  Fly  1515 DGAGITLVTPGCSKAGGIPNDG-------SSLGEGSDSGRLRR--SGSERIKDQAKALLRRVESI 1570

Zfish   253 K--KRDSEN-EKVLKSVSTVTRHQPLSGLHCTSDASLPGQTTNKCRNTKDPSWRAHTICRSNVSQ 314
            |  :|..:| |.|:.|..||                                     :..|...|
  Fly  1571 KSRRRKRQNRENVVISGPTV-------------------------------------LDLSQFGQ 1598

Zfish   315 KVTLHKPHRACLYLEDYQLTWEIPKSTSHNNRQRKEDRVVHLPFDHKPGTFPKS------LSIES 373
            :.:|.||          ...:..|.|.|..:...               ||||:      |.:.|
  Fly  1599 RSSLRKP----------DAVYSTPPSPSALSPMH---------------TFPKAPFFGNDLKVPS 1638

Zfish   374 -----------------LCPVSVSESPDHIDWAGVDGDLSLDGSVSRSGSQDFLSGFGQRRNSIS 421
                             ..|.|:..||.|.                      |.|...|.:...|
  Fly  1639 HSDNFLSPNRSSPKRTPTTPRSMRTSPLHF----------------------FSSPMSQLKEGKS 1681

Zfish   422 SLGSIY--DNVPETPGSPGDIFDPGKKKVFQH----LDDILQHVHGLQHNIEEWSRSLGIQPQDQ 480
            ...|.|  |:...:.|....:..|.|.:.|..    :|||..|.....|.    .|.|.|:..:
  Fly  1682 DDSSSYYSDSQESSTGGKLSLRKPSKARRFLQRTGKVDDIGAHSDSECHQ----GRKLLIKDAN- 1741

Zfish   481 SNAETVSTADTTLPSSLNYDEQSMSDVGTTVSDYDSAGNSVNEGEGEGEMRERRDSGVGASLTRP 545
            ||...|.....|...|||..:......|...|.:.|...|..|.:.:       :...||:....
  Fly  1742 SNTTEVKVKKLTRGGSLNLGKDPKKRDGFRSSSFRSRSTSRKEAKND-------EDTAGATTNGG 1799

Zfish   546 SRK---LRWHSFQNSHRPSV---------------SSASLEINRQSAAQLNLLQKFSLLRLTAIL 592
            |::   :||||||...||::               .:..:.....||.||.:::|.:|:.||..:
  Fly  1800 SKRQPVVRWHSFQMEERPNMIFRKCFSKKIEPLQEDAGGMPFAAMSAGQLQIIRKLALVTLTGHM 1864

Zfish   593 EKHTDTSKHGWNWVVPKFMKRSKVPDYKDKHVFGVPPIVNVQRTGQPLPQSIQQAMRYLRSQCLE 657
            |::..:.:.||||.:|||:|:.|:||||||.|||||.::.:||:||.||.:::.|.|:|:...|:
  Fly  1865 ERYCPSHRSGWNWELPKFIKKIKMPDYKDKKVFGVPLLMILQRSGQTLPLAVRAAFRWLQLNALD 1929

Zfish   658 KVGIFRKSGVKSRIQALRQLNENSPDHV----TYQGQSAYDVADLIKQYFRDLPEPVLTSKLTDT 718
            :||||||||.||||..||:..|.:....    .:..|.||||||::|||||:|||.:||:|:::|
  Fly  1930 QVGIFRKSGGKSRIMKLREQIEVTDSTAECMDVFDLQQAYDVADMLKQYFRELPESLLTTKMSET 1994

Zfish   719 FLHVYQFVPAEQRLQAVQAAVILLPDENREVLQTLLYFLSDI-ASAQENQMTADSLAVCLAPSIL 782
            |:.::|.:|||.||.|||.||:||||||||:|..||.||:.: |::|:||||:::|.||||.||.
  Fly  1995 FVAIFQHLPAEVRLDAVQCAVLLLPDENREILYVLLEFLTIVAANSQQNQMTSNNLGVCLAQSIF 2059

Zfish   783 HLN---ASKKDGASPRLISRKGGAKPDHKDLSENMAATHCLSHMITECKKLFQIPHEMMLQSRNS 844
            |.:   .|....||||. ..||...||.|:|:|..|:..|||.||...|:::....|.:.:...|
  Fly  2060 HSSISTGSASVSASPRR-KGKGSGMPDMKELAEAKASHECLSFMIEHYKQIYTAAKEKLSKCNFS 2123

Zfish   845 YVAADAQPLPLHGLGVNALGEPV---DYRAYLEDNVQCLLREASERSKGWH--HAHGPDNTELAY 904
            |: .:::||||     .||||.:   ::|.||.:.....::|..|:::||.  ::....:.::||
  Fly  2124 YM-EESKPLPL-----EALGEGMQFHNWRGYLYECTSATIKEGREKTRGWFSINSLNDSSVDIAY 2182

Zfish   905 KKVGDGHPMRIWRVSVEIEAPPSVVLQRVLRERHLWDEDLLHSRVIETLENNTEVFHYITDSMAP 969
            ||||||||:|:||.|.|||.||..||:.|:::|..||.:||..:.::.|::.||::.|..|...
  Fly  2183 KKVGDGHPLRLWRCSTEIEGPPKEVLEFVIKQRASWDTNLLQCQTVKKLDDRTEIYQYALDGQL- 2246

Zfish   970 HPRRNFITLRRWCSDLPKGVCVLVSSSVDHDNVQ-LEAGLRAVLLTSRMFIEPCGMGRSRLTHYC 1033
              ..:|..||.|.:|||:|.||:|.:|:||...: |...:|.|:|.||..|||||.||||:.|..
  Fly  2247 --TTDFCVLRSWQTDLPRGACVIVETSIDHAKAKPLFGAVRGVVLASRYLIEPCGSGRSRVMHLA 2309

Zfish  1034 RADLRGRSPDWYNKVFGHLCAMEVARIRSSFPVLTARGPETKL 1076
            |.|::|::|:||||.:||:|:..::|||.:|..: |.|||:|:
  Fly  2310 RVDVKGKTPEWYNKNYGHICSHYLSRIRLAFKHV-ADGPESKV 2351

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
stard8	NP_001119949.1	SAM_DLC1,2-like	43..102	CDD:188937	33/58 (57%)
		RhoGAP_DLC1	621..837	CDD:239840	109/223 (49%)
		START_STARD8-like	863..1067	CDD:176916	87/209 (42%)
cv-c	NP_001097786.1	SAM_DLC1,2-like	1382..1441	CDD:188937	33/58 (57%)
		RhoGAP_DLC1	1893..2116	CDD:239840	109/223 (49%)
		SRPBCC	2148..2343	CDD:301327	83/197 (42%)

Information from Original Tools

Tool	Simple Score	Weighted Score	Original Tool Information
			BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	1	1.000	196	1.000	Domainoid score	I3074
eggNOG	1	0.900	-	-		E1_KOG2200
Hieranoid	1	1.000	-	-
Homologene	0	0.000	Not matched by this tool.
Inparanoid	1	1.050	598	1.000	Inparanoid score	I926
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	1	1.000	-	-		FOG0001209
OrthoInspector	1	1.000	-	-		otm25015
orthoMCL	1	0.900	-	-		OOG6_103453
Panther	1	1.100	-	-	O	PTHR12659
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	1	1.000	-	-		X752
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
ZFIN	0	0.000	Not matched by this tool.
	10	9.860