DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment WWC3 and wwc3

DIOPT Version :9

Sequence 1:	NP_056506.2	Gene:	WWC3 / 55841	HGNCID:	29237	Length:	1092	Species:	Homo sapiens
Sequence 2:	NP_001103940.1	Gene:	wwc3 / 566492	ZFINID:	ZDB-GENE-070209-229	Length:	1148	Species:	Danio rerio

Alignment Length:	1129	Identity:	621/1129 - (55%)
Similarity:	779/1129 - (68%)	Gaps:	98/1129 - (8%)

- Green bases have known domain annotations that are detailed below.

Human     1 MDHINKLTQIEDPREQWRREQERMLKEYLIVAQEALNAKKEIYQIKQQRFELAQEEYQQLHKMCE 65
            :|||||.||||:||.|||:||||||||||:|||||||||||:|||||||.||||:|.|..:::.:
Zfish    81 IDHINKTTQIENPRTQWRQEQERMLKEYLVVAQEALNAKKEMYQIKQQRLELAQQEMQLFNQLTQ 145

Human    66 DDSRSYASSFSGYSTNTKYDPHQIKAEIASRRDRLSRLKRELTQMKQELQYKEKGVETLQEIDRK 130
            ||:||..||.||.|:|.||||.|||||||.||:||||||:||.||:|||||||.|||||||||||
Zfish   146 DDNRSITSSHSGSSSNAKYDPDQIKAEIACRRERLSRLKQELAQMRQELQYKEMGVETLQEIDRK 210

Human   131 MSSTHTSYKLDEAQAIMSELRTIKKAICTGEKERRDLMHSLAKLTDSFKNSCSVTDSLVDFPHHV 195
            |||:.|:|||||||||.||||:|||||.||||||:||:.||||||.:|   |   ||:.:..::.
Zfish   211 MSSSQTNYKLDEAQAIFSELRSIKKAISTGEKERQDLIQSLAKLTLNF---C---DSINEVTNNA 269

Human   196 GVPGDAGVPQQFCDAGSQTDIIGEFVFDDKTRLVDRVRLNWQYEEARKRVANIQQQLARLDNESW 260
            ....|:...||:.|||.|||::|||...:.:.|.|||:|:||||||:|::::||.|||:||:|||
Zfish   270 ESLADSCSVQQYTDAGCQTDLMGEFGSQESSLLADRVKLSWQYEEAKKKMSSIQHQLAQLDSESW 334

Human   261 PSTAEADR--DRLQLIKEKEALLQELQLIIAQRRSAGDVARLEEERERLEEELRRARATSAQGAT 323
            ...|||||  |.|||::|||.|||||.|:..|:.|:..:.:|:||:.||::|::||.:..:|||.
Zfish   335 SGRAEADRDWDCLQLLREKETLLQELTLLSQQQHSSDTLLQLQEEKRRLQDEVQRAHSAQSQGAN 399

Human   324 ERILLQEKRNCLLMQLEEATRLTSYLQSQLKSLCASTLTVSSGSSRGSLASSRGSLASSRGSLSS 388
            :|||||||||.|:.|||||||:|:||.||||||.||.|||||.||||||||||||||||||||||
Zfish   400 QRILLQEKRNVLMRQLEEATRITTYLHSQLKSLSASNLTVSSSSSRGSLASSRGSLASSRGSLSS 464

Human   389 VSFTDIYGLPQYEKPDAEGSQL---LRFDLIPFDSLGRDAPFSEPPGPSGFHKQRRSLDTPQSLA 450
            ||||||||||||::.:.....|   .|: |:|.:|....:.:    ||      :||.||||||.
Zfish   465 VSFTDIYGLPQYDRTEGSSDVLDPSFRY-LLPLESHSSGSAY----GP------KRSHDTPQSLT 518

Human   451 SLSSRSSLSSLSPPSSPLDTPFLPASRDSPLAQLAD-----SCEG---PGLGALDRLRAHASAMG 507
            |||||||||||||||||:|||:..|.:|.||||:.:     :..|   .||....:.:.|.:..|
Zfish   519 SLSSRSSLSSLSPPSSPMDTPYHSAPQDCPLAQMTEEYMEVASRGLLAEGLRTQSQAQQHTTLSG 583

Human   508 DEDLPGMAALQPHGVPGDGEGPHERGPPPASAPVGGT-----VTLREDSAKRLERRARRISACLS 567
            |.:: |:|| ..|.:    ||...|     .|.:.||     ||||..||.|..|||||:||.::
Zfish   584 DGEV-GIAA-TAHLL----EGKSHR-----DAALQGTHSSTGVTLRCKSASRTSRRARRVSAGVN 637

Human   568 DYSLASDSGVFEPLTK-RNEDAEEPAYGD--TASNGDP-QIHVGLLRDSGSECLLVHVLQLKNPA 628
            :..||:||||||..:: |.|::||.::..  |.:..:| .|.:|||.||.|..||:||||::|.:
Zfish   638 EDVLATDSGVFEAWSRSRTEESEEVSFAQDVTVAVSEPVHIQIGLLYDSNSRFLLLHVLQMRNLS 702

Human   629 GLAVKEDCKVHIRVYLPPLDSGTPNT-YCSKALEFQVPLVFNEVFRIPVHSSALTLKSLQLYVCS 692
            ..::::..||.::|::.|:||..|.| ||.||.|.|..|.|||.||||:........:||..:.:
Zfish   703 KASIRDRWKVFVKVHVLPMDSSRPCTYYCCKAQEPQSLLSFNESFRIPLSVGGPGAHALQFSLST 767

Human   693 VTPQLQEELLGIAQINLADYDSLSEMQLRWHSVQVFTS----------SEPSRTREAGCAGESSA 747
            :.|..||||||.||::|.|....:||..:|..||..::          |:|:|..:     |...
Zfish   768 LGPLAQEELLGSAQVSLTDCVGSTEMLFQWLKVQFHSTENHRPEHRRLSQPNRIMD-----EEEE 827

Human   748 RDPAHTISISGKTDAVTVLLARTTAQLQAVERELAEERAKLEYTEEEVLEMERKEEQAEAISERS 812
            ::..     .||.:.             :|...|.|.:.:|:.:||   |:|||||..||:||||
Zfish   828 KNEG-----QGKLEV-------------SVVSHLEEMKKELQRSEE---ELERKEEPGEAVSERS 871

Human   813 WQADSVDSGCSNCTQTSPPYPEPCCMGIDSILGHPFAAQAGPYSPEKFQPSP-LKVDKETNTEDL 876
            |||:||||||||.|....|.||..|       |......:|....:..:.:| :||||.||||.:
Zfish   872 WQAESVDSGCSNSTAFVIPCPESLC-------GEGICLTSGRRCLQPAERNPIIKVDKATNTEGV 929

Human   877 FLEEAASLVKERPSRRARGSPFVRSGTIVRSQTFSPGARSQYVCRLYRSDSDSSTLPRKSPFVRN 941
            |.|......|||..|....|||:||.|||||||||||||||||||||||||||||||:||||:||
Zfish   930 FAEPMRMRPKERTGRWGHSSPFMRSSTIVRSQTFSPGARSQYVCRLYRSDSDSSTLPKKSPFIRN 994

Human   942 TLERRTLRYK-QSCRSSLAELMARTSLDLELDLQASRTRQRQLNEELCALRELRQRLEDAQL--R 1003
            |||||||||| ||.||||||...||||||||||||.|||||||.|||.|||||:.|||:...  |
Zfish   995 TLERRTLRYKQQSHRSSLAEQPTRTSLDLELDLQACRTRQRQLTEELAALRELKLRLEEPMQGPR 1059

Human  1004 GQTDLPPWVLRDERLRGLLREAERQTRQTKLDYRHEQAAEKMLKKASKEIYQLRGQSHKEPIQVQ 1068
            |..|||.|.|||||.|.|||||:||::||:.:.|.|:|||:.|:|||||:.|:||||||||:.||
Zfish  1060 GPADLPHWALRDERFRNLLREAQRQSKQTRQEQRQEEAAERRLRKASKEVLQMRGQSHKEPLPVQ 1124

Human  1069 TFREKIAFFTRPRINIPPLPADDV 1092
            ||:||:|||||||.||||||||||
Zfish  1125 TFKEKMAFFTRPRFNIPPLPADDV 1148

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
WWC3	NP_056506.2	THOC7	<4..119	CDD:283305	85/114 (75%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	363..384		19/20 (95%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	422..488		36/70 (51%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	510..544		8/33 (24%)
		C2_Kibra	602..725	CDD:176062	53/124 (43%)
wwc3	NP_001103940.1	WW	17..46	CDD:278809
		WW	64..93	CDD:278809	9/11 (82%)
		C2_Kibra	677..800	CDD:176062	52/122 (43%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C194337850
Domainoid	1	1.000	1052	1.000	Domainoid score	I366
eggNOG	1	0.900	-	-		E1_COG5021
Hieranoid	1	1.000	-	-
Homologene	1	1.000	-	-		H9243
Inparanoid	1	1.050	1052	1.000	Inparanoid score	I2084
NCBI	1	1.000	-	-
OMA	1	1.010	-	-		QHG50236
OrthoDB	1	1.010	-	-		D181722at33208
OrthoFinder	1	1.000	-	-		FOG0013263
OrthoInspector	1	1.000	-	-		oto50731
orthoMCL	1	0.900	-	-		OOG6_103792
Panther	1	1.100	-	-	LDO	PTHR14791
Phylome	1	0.910	-	-
RoundUp	1	1.030	-	avgDist	Average_Evolutionary_Distance	R17571
SonicParanoid	1	1.000	-	-		X1418
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	1	0.960	-	-
ZFIN	1	1.500	-	-
	18	18.300