Protein Alignment WWC3 and kibra

DIOPT Version :10

• Sequence 1: NP_056506.3
• Gene: WWC3 / 55841
• HGNCID: 29237
• Length: 1217
• Species: Homo sapiens
• Sequence 2: NP_001034055.1
• Gene: kibra / 41783
• FlyBaseID: FBgn0262127
• Length: 1288
• Species: Drosophila melanogaster
• Alignment Length: 1257
• Identity: 386/1257 - (30%)
• Similarity: 608/1257 - (48%)
• Gaps: 251/1257 - (19%)

Human    58 AELPLPAGWEEARDYDGRVFYIDHNTRQTSWIDPRDRITKPLTFADCVGDELPLGWETVYDKQIG 122
            ::.|||.||:.|:|:||:.:||||..::|:|:||||..|||.||.||||||||:|||..||..||
  Fly    52 SDFPLPDGWDIAKDFDGKTYYIDHINKKTTWLDPRDCYTKPQTFEDCVGDELPMGWEESYDPNIG 116

Human   123 VYYMDHINKLTQIEDPREQWRREQERMLKEYLIVAQEALNAKKEIYQIKQQRFELAQEEYQQLHK 187
            .||::|:.:.||:||||::|:..||:||.:||..||:.|..|:|::.:||||...|||||..| |
  Fly   117 PYYINHLAQSTQLEDPRQEWKTVQEQMLSDYLSAAQDQLENKREMFDVKQQRLLWAQEEYNHL-K 180

Human   188 MCEDDSRSYASSFSGYSTNTKYDPHQIKAEIASRRDRLSRLKRELTQMKQELQYKEKGVETLQEI 252
            :    :.|.:|..|..|:.:::||..::|::...|:|:.:||:|||.:..::.|.|:|:.||..:
  Fly   181 L----AASRSSLCSSSSSMSRHDPELLRADLMLARERVHQLKQELTHITNDISYTERGMNTLYSV 241

Human   253 DRKMSSTHTS-YKLDEAQAIMSELRTIKKAICTGEKERRDLMHSLAKLTDSF-KNSCSVTDSLVD 315
            ..|:::.... |.:.|..||..|:..:.|::.:|||.|.:||.||.::.:.. :...|..:|
  Fly   242 GEKINARENGCYDIAEVHAIREEMLKVHKSLVSGEKVREELMRSLVQIKNELGRQQISEENS--- 303

Human   316 FPHHVGVPGDAGVPQQFCDAGSQTDIIGEF--VFDDKTRLVDRVRLNWQYEEARKRVANIQQQLA 378
                     |...|.......||||:.|..  ..:...|..:..:..|||.|.||.:..:|||||
  Fly   304 ---------DLASPFDRVCVASQTDLCGSSGENLNGGARFAEMAKTKWQYAEWRKHIKKLQQQLA 359

Human   379 RLDNESWPSTAEADRDRLQLIKEKEALLQELQLIIAQRRSAGDVARLEEERERLEEELRRARATS 443
            .......|...|:|:||:.||:|||.||.:|..|..:.||..:...:.:.|.:|||:|:.|...:
  Fly   360 DHVERIEPGQLESDKDRILLIQEKEKLLNDLNSISLKSRSEEEKRVIHQTRHKLEEDLKEAYEAN 424

Human   444 AQGATERILLQEKRNCLLMQLEEATRLTSYLQSQLKSLCA-STLTVSSGSSRGSLASSRGSLASS 507
            ......|:...|::..||.:|:||.:.|..|:.:|||..: ||.::|||||.|||     |.|||
  Fly   425 NTCVANRLRFHEEKQLLLDKLQEALKSTKLLEERLKSFSSESTFSISSGSSLGSL-----STASS 484

Human   508 RGSLSSVSFTDIYGLPQYEKPDAEGSQLLRFDLIPFDSLGRDAP-------------FSEPPGPS 559
            :   |::||||||                      .|....|:|             |.:
  Fly   485 K---SALSFTDIY----------------------IDPFAVDSPIDVVDLRRRSQRLFQQ----- 519

Human   560 GFHKQRR------SLDTPQSL-ASLSSRSSLSSLSPPSSPL-------DTPFLPASRDSPLAQLA 610
              |:|:|      .|...||. .:||.|||||..:||:||:       .||  .|.::.|  ..|
  Fly   520 --HQQQRLHPVHPVLQQQQSAEVTLSPRSSLSMETPPASPMKYNAGADQTP--QALKEEP--TYA 578

Human   611 DSCEGPGLGALDRLRAHASAMGDEDLPGMAALQPHGVPGDGEGPHE------------------- 656
            ::...|                    |...|..|..:.|....|::
  Fly   579 NALPAP--------------------PAYTAPPPVPISGVRARPYDLDSTVLDCMMLEAKLQKLN 623

Human   657 RGPP------PASAPVGGTVTLREDSAKRLER-----RARRISACLSDYSLASDSGVFEPLTKRN 710
            .|.|      |.| |:....:|.:...:.|.|     ..|.:||.:|:.|:|.|||||| .::.:
  Fly   624 MGTPLNLAVAPLS-PISEKPSLLDLPQEMLSRSSSTSNTRSVSAAVSNESVAGDSGVFE-ASRAH 686

Human   711 EDAEEPAYGDTASNGDPQIHVGL--LRDSGSECLLVHVLQLKNPAGL--AVKEDCKVHIRVYLPP 771
            ...:|.|          |:.:||  |:..|  .|:|.:.:..|...|  |..::.:|::|..|
  Fly   687 LPRKELA----------QVQIGLKYLKQEG--VLVVSLERANNLLALWTASADNSQVYLRAAL-- 737

Human   772 LDSGTPNTYCS---KAL-EFQVPLVFNEVFRIPVHSSALTLKSLQLYVCSVTPQLQEELLGIAQI 832
                .||:..|   ||| :||.| |||:.|.:|:....|..||||:.|.::|.| :||::|..||
  Fly   738 ----LPNSLTSIRTKALGDFQKP-VFNDTFAVPITLDKLLTKSLQVTVVTMTGQ-KEEIIGTVQI 796

Human   833 NLADYDSLSEMQLRWHSV------QVFTSSE-PSRTREAGCA--GESSARDPAHTISISGK---- 884
            ::|:::. .:..|:|::|      ..|.|.: ||.:..|..|  ..|:|.:|.:....|..
  Fly   797 SMAEFNP-EDSTLKWYNVLSSKFIPSFESLDIPSTSAAAAAAAVAASNAPNPGNNREESSDESTI 860

Human   885 TDAVTVLLARTTAQLQAVERELAEERAKLEYTEEEVLEMERKEEQAEAISERSWQADSVDSGCSN 949
            |.:.|..|.|..|....::.::|.|...|....|.....:..:::.|.:.::...:   |.|..|
  Fly   861 TSSQTSTLTRNQAPCMELQEQMAAELLGLGPLNEPECSDDDDDDEEEELDDKQLVS---DVGLMN 922

Human   950 CTQTSPPYPEPCCMGIDSILGHPFAAQAGPYSPEKFQPSPLKVDKETNTEDLFLEE----AASLV 1010
            .:.....|.:.        :...||                  ||||||:..:|.|    .:.|:
  Fly   923 SSSMLHAYLQN--------MKQEFA------------------DKETNTDRAYLPEKSRGQSQLM 961

Human  1011 KERPSRRARGSPFVRSGTIVRSQTFSPG---ARSQYVCRLYRSDSDSSTLPRKSP--FVRNTLER 1070
            .:||              :.|||||:|.   ::::|.|||.||||||:.....:|  |.|...||
  Fly   962 DDRP--------------VKRSQTFTPSEAFSKNRYNCRLNRSDSDSAMHCGVAPHTFQRGAAER 1012

Human  1071 RTLRYKQSCRSSLAEL----MARTSLDLELDLQASRTRQRQLNEELCALRELRQRLEDAQLRGQT 1131
            |:||:......|:.:|    :.||||||||||||..::...||:::..|:.|::.|:.|......
  Fly  1013 RSLRFHSKAPKSVTKLHHTHIPRTSLDLELDLQAQHSKLYFLNDQIAKLQNLKEVLQKACENKDP 1077

Human  1132 DLPPWVLRDERLRGLLREAERQTRQTKLDYRHEQAAEKMLKKASKEIYQLRGQSHKEP---IQVQ 1193
            .:..|.:.:|..:.|:..|:      ......|:..:|:|.|.:|||::||  ..|.|   ..:.
  Fly  1078 LVAAWAIENEEFQRLVARAD------PAKCPEERQLQKLLMKTAKEIHKLR--KTKVPKGCPDLV 1134

Human  1194 TFREKIAFFTRPRINIPPLPAD 1215
            :|:|||.||||..:::|.||::
  Fly  1135 SFKEKITFFTRKGLSVPELPSE 1156

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
WWC3	NP_056506.3	WW	62..91	CDD:459800	14/28 (50%)
		WW	109..138	CDD:459800	15/28 (54%)
		THOC7	127..244	CDD:461692	45/116 (39%)
		DR0291	213..>304	CDD:441187	28/92 (30%)
		EnvC	216..>419	CDD:443969	64/206 (31%)
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	488..509		12/20 (60%)
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	547..613		25/92 (27%)
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	635..669		10/58 (17%)
		C2_Kibra	727..850	CDD:176062	43/130 (33%)
		Interaction with PRKCZ. /evidence=ECO:0000269|PubMed:24682284	1061..1080		8/20 (40%)
kibra	NP_001034055.1	WW	57..87	CDD:238122	15/29 (52%)
		WW	103..132	CDD:459800	15/28 (54%)
		C2_Kibra	693..813	CDD:176062	44/140 (31%)