DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment WWC3 and ctrip

DIOPT Version :9

Sequence 1:	NP_056506.2	Gene:	WWC3 / 55841	HGNCID:	29237	Length:	1092	Species:	Homo sapiens
Sequence 2:	NP_001189170.1	Gene:	ctrip / 40596	FlyBaseID:	FBgn0260794	Length:	3140	Species:	Drosophila melanogaster

Alignment Length:	982	Identity:	184/982 - (18%)
Similarity:	312/982 - (31%)	Gaps:	273/982 - (27%)

- Green bases have known domain annotations that are detailed below.

Human    68 SRSYAS--------SFSGYSTNTKYDPHQIKAEIASRRDRLSRLKRELTQMKQELQYKEKGVETL 124
            |.|::|        |..|.....:..||  :...|:|..|...|          |.|..|
  Fly   256 STSFSSSHRNKRKASIGGSIAAVETTPH--RGTAAARAGRSGNL----------LNYYRK----- 303

Human   125 QEIDRKMSSTHTSYKLDEAQAIMSELRTIKKAICTGE----------KERRDLMHSLAKLTDS-- 177
               .||:|.|.:|.| .|.|:|.:|..|..:....|.          |.|:.|.||...|.|:
  Fly   304 ---TRKVSHTRSSQK-SEKQSIPAEDTTANRNGSAGSGSSSKSGVIPKNRKSLRHSQQNLLDTEA 364

Human   178 --FKNSCSVTDSLVDFPHHVGVPGDAGVPQQF--CDAG-SQTDIIGEFVFDDKTRLVDRVRLNWQ 237
              .:::.:.|.......|     |:..|..|.  .:|| :|::..|             :....|
  Fly   365 AEVESAAAETGGEQQSEH-----GNLDVIDQLPTPEAGPNQSEASG-------------IHNQSQ 411

Human   238 YEEARKRVANIQQQLARLDNESWPSTAEADRDRLQLIKEKEALLQELQLIIAQRRSAGDVARLEE 302
            .|..|:.|  :|.:....|:|......|.:.....::....:..:|...|:|:.   .::...||
  Fly   412 LEADRQPV--VQDEDDEEDDEEEEEEEEEEVGFYGIVNSAGSSYEEDTQIVAEE---DEITTEEE 471

Human   303 ERERLEEELRRARATSAQGATERI--LLQEKRNCLLMQLEEATRLTSYLQSQLKSLCA------- 358
            ..:..::|:.....:.::.|.:.|  |..|::     |.:.||......::...::.|
  Fly   472 VDDEDDDEIEEEDLSESEFAQQLIGELGGERQ-----QPQRATNNAKKTKNNTPAVAAASTIKAT 531

Human   359 STLTVSSGSSRGSLASSRGSLASSRGSLSSVSFTDIYGLPQYEKPDAEGS--QLLRFDLIP-FDS 420
            :|.|.|||..:.:....:|:...:.|           |.|:..:.....|  .::.:.::| ..:
  Fly   532 TTATTSSGYQQRAAPHGQGAAPGAGG-----------GGPRATRSSNSNSSNNVVDYSIMPHLTT 585

Human   421 LGRDAPFS----------EPPGPSGFHKQR-RSLDTPQSLASLSSRSSLSSLSPPSSPLDTPFLP 474
            :....|.:          :||.|....:|: .....|..|......:.|||..       ||...
  Fly   586 VATTTPHALTPQQHQQQRQPPQPPSHQQQQVHQQQQPPQLLPTHQFAHLSSFV-------TPTAA 643

Human   475 ASRDSPLAQLADSCEGPGLGALDRLRAHASAMGDEDLPGMAALQPHGVPGD-----GEGPHE--- 531
            |:..:..|....:.......|..:...|......:.:....|.|||.....     ...||.
  Fly   644 AAAAAAAAHYPPASAAAAYFAQQQHHQHQHQHQQQHVQQAQAPQPHYYHSSVAVLHQPPPHHFTS 708

Human   532 --RGPPPASAPVGGTVTLREDSAKRLERRARRISACLSDYSLASDSGVFEPLTKRNEDAEEPAYG 594
              .|||||        ..::.:..:|.|...         :.|:.:..|.|          |...
  Fly   709 TGAGPPPA--------LFQQQAPPQLTRYTP---------ATATTAATFVP----------PQQQ 746

Human   595 DTASNGDPQIHVGLLRDS----GSECLLV---------HVLQLKNPAGLAVKEDCKVHIRVYLPP 646
            ....|...|.|..|.|.|    || |:..         |..|..:.|..||::.       .|||
  Fly   747 QVVYNPQQQQHSSLRRSSRGKTGS-CVSSAAAAQQQQHHQQQQHSSAAAAVQQQ-------LLPP 803

Human   647 LDSGTPNTYCSKALEFQVPLVFNEVFRIPVHSSALTLKSLQLYVCSVTPQLQEELLGIAQINLAD 711
                 |.||     ::| .:..|.|.....|...|..:..|....::..|.|::         ..
  Fly   804 -----PGTY-----QYQ-QVGGNTVVVAVRHQQQLQQQQQQQQQLALHHQHQQQ---------QH 848

Human   712 YDSLSEMQLRWHSVQ------------VFTSSEPSRTREAGCAGESSARDPAHTISISGKTDAVT 764
            .....:.|.:.|..|            .:.|::|.:.::   ..:...:.|..|.| |..:||:|
  Fly   849 QQQQQQHQQQQHQQQQRATLVQPGFLFSYRSNQPQQQQQ---PAQQIHQGPKVTHS-SAASDALT 909

Human   765 V-LLAR------------------TTAQLQAVERELAEER-------------AKLEYTEEEVLE 797
            . |:|:                  .:|.|..|...|:..|             .....|......
  Fly   910 YSLMAQQPPSGPPHAGGQQITPGANSANLSIVAAALSAARDVGGGSDGGGSAGGATPATGASASS 974

Human   798 MERKEEQAEAISERSWQADSVDSGCSNCTQT---SPPYPEPCCMGIDSILGHPFAAQAGPYSPEK 859
            :........:.|..|....:..|..:|.|.|   |.|...|...|..|...|...:.|.
  Fly   975 VGNTSAVGASSSSNSSAGQAASSNSNNVTATGSGSAPGGGPTSTGTTSGTQHGSGSGAA------ 1033

Human   860 FQPSPLKVDKETNTEDLFLEEAASLVKERPSRRARGSPFVRSGTIVRSQTFSPGARSQYVCRLYR 924
                 ..||.|::..::...:|.        ..|||.|....|.:        |.|..::  |:|
  Fly  1034 -----AAVDSESDDSEVGRLQAL--------LEARGLPPHLFGAL--------GPRVTHI--LHR 1075

Human   925 SDSDSST 931
            :..:||:
  Fly  1076 TIGNSSS 1082

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
WWC3	NP_056506.2	THOC7	<4..119	CDD:283305	13/58 (22%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	363..384		4/20 (20%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	422..488		14/76 (18%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	510..544		11/43 (26%)
		C2_Kibra	602..725	CDD:176062	29/135 (21%)
ctrip	NP_001189170.1	Extensin_2	<688..731	CDD:252669	11/50 (22%)
		WWE	1409..1481	CDD:128922
		FAM199X	<1985..2074	CDD:292442
		HECTc	<2818..3138	CDD:294058
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_COG5021
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	1	0.900