DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment WWC3 and Nedd4

DIOPT Version :9

Sequence 1:	NP_056506.2	Gene:	WWC3 / 55841	HGNCID:	29237	Length:	1092	Species:	Homo sapiens
Sequence 2:	NP_648993.1	Gene:	Nedd4 / 39958	FlyBaseID:	FBgn0259174	Length:	1007	Species:	Drosophila melanogaster

Alignment Length:	503	Identity:	101/503 - (20%)
Similarity:	171/503 - (33%)	Gaps:	173/503 - (34%)

- Green bases have known domain annotations that are detailed below.

Human   599 NG-DPQIHVGLLRDSGSEC-LLVHVLQLKNPAGLAVKEDCKVHIRVYLPPLDSGTPN--TYCSKA 659
            || .|:..:..:.|||..| |.:.||..::.|...:......::|:.|..: :|..|  :..:|.
  Fly    52 NGYTPRRSLAAVNDSGDSCHLRIVVLTGQSLAKKDIFGASDPYVRIDLNTI-NGDINIDSVLTKT 115

Human   660 LEFQVPLVFNE--VFRIPVHSSALTLKSLQLYVCSVTPQLQEELLGIAQINLADYDSLSEMQLRW 722
            .:..:...:||  :||:......|..:     |.......:::.||:.::.|.:..  :|.:.|.
  Fly   116 KKKTLNPTWNEEFIFRVKPSEHKLVFQ-----VFDENRLTRDDFLGMVELTLVNLP--TEQEGRT 173

Human   723 HSVQVFT-----------------------------SSEPSRTR--------EAGCAGESSARD- 749
            ...|.:|                             .||||...        ||..|||:||:.
  Fly   174 IGEQSYTLRPRRSVGAKSRIKGTLRIYHAFIRETREQSEPSSGNSDGEWEHVEATNAGETSAQPH 238

Human   750 ----------PA----------------HTISISGKTDAVTVLLARTTAQLQAVERELAEERAKL 788
                      ||                ||...: :.|..|||.:.::   |:.:.:||.:..:.
  Fly   239 PFPTGGHDALPAGWEERQDANGRTYYVNHTARTT-QWDRPTVLNSHSS---QSTDDQLASDFQRR 299

Human   789 EYTEEEVLEMERKEEQAEAISERSWQADSVDSGC-----SNCTQTSPPYPEPCCMGIDSILGHPF 848
            .:...:..|..|   .|::||..|.:.::..:|.     :..|.::||.......||       .
  Fly   300 FHISVDDTESGR---SADSISHNSIEDNNNAAGLAYTPKTAATSSAPPNTPTNNNGI-------L 354

Human   849 AAQAGPYSPEKFQ-PSPLKVDKETNTEDLFLE------------EAASLVKE-RPSRRARG---- 895
            |..|..|..|:.| |:   ||   :|..::..            .|.||..: ||.|.|.|
  Fly   355 AQIAMQYRAEEDQDPT---VD---HTSFVYNSLRHPVAHRQPEISATSLQNDLRPVREAPGVPDI 413

Human   896 ---SPFVRSGTIVRSQTFSPGARSQYVCRLYRSDSDSSTLPRKSPFVRNTLERRTLRYKQSCRSS 957
               :||.|..    :...:.||..|.                         |||
  Fly   414 AITNPFTRRA----AGNMAGGAGWQQ-------------------------ERR----------- 438

Human   958 LAELMARTSLDLELDLQASRTRQRQLNEELCALRELRQRLEDAQLRGQ 1005
                  |..:.|.:.....|.:|:|.|.   .|.::..|.::.|.|||
  Fly   439 ------RQQMQLHIQQHQQRQQQQQQNR---ILLDVDHRQQEPQHRGQ 477

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
WWC3	NP_056506.2	THOC7	<4..119	CDD:283305
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	363..384
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	422..488
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	510..544
		C2_Kibra	602..725	CDD:176062	25/127 (20%)
Nedd4	NP_648993.1	C2_NEDD4_NEDD4L	71..204	CDD:175999	22/140 (16%)
		WW	248..277	CDD:278809	5/29 (17%)
		WW	531..560	CDD:278809
		WW	581..613	CDD:197736
		HECTc	650..1003	CDD:238033
		HECTc	674..1003	CDD:214523
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_COG5021
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	1	0.900