DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment WWC3 and Ube3a

DIOPT Version :9

Sequence 1:	NP_056506.2	Gene:	WWC3 / 55841	HGNCID:	29237	Length:	1092	Species:	Homo sapiens
Sequence 2:	NP_648452.1	Gene:	Ube3a / 39266	FlyBaseID:	FBgn0061469	Length:	973	Species:	Drosophila melanogaster

Alignment Length:	493	Identity:	98/493 - (19%)
Similarity:	170/493 - (34%)	Gaps:	134/493 - (27%)

- Green bases have known domain annotations that are detailed below.

Human   364 SSGSSRGSLASSRGSLASSRGSLSS-----VSFTDIY---GLPQYEKPDAEGSQLLRFDLIPFDS 420
            |||||..::.|:..:..:||.|.|:     |..:..|   .:||.:...||.|.
  Fly   119 SSGSSTSTITSASTTTTTSRQSQSTPAAVVVPVSSPYLTQSVPQLDIAGAEHSS----------- 172

Human   421 LGRDAPFSEPPGPSGFHKQRRSLDTPQSLASLSSRSSLSSLSPPSSPLDTPFLPASRDSPLAQLA 485
             |...|.:....|.      .|||....:|......:..|.......:...|  :|.|.......
  Fly   173 -GDSEPCTPTLAPV------HSLDANSLIALYEQCRAADSYDRICHAIGVVF--SSVDRLGKSFI 228

Human   486 DSCEGPGLGALDRLRAHA-SAMGDEDLPGMAALQPHGVPGDGEGPHERGPPPASAPVGGTVTLRE 549
            .|.|.....:|..|.|:: .|:..|.|..:            ||.|::.               |
  Fly   229 RSAEPAASSSLQELLANSPGALNKEQLRTL------------EGEHDKD---------------E 266

Human   550 DSAKRLERRARRISACLSDYSLASDSGVFEPLTKRNEDAEEPAYGDTASNGDPQIHV-GLLR--- 610
            ||.::::.::.         |.|:.:...|.:....|..||.....::.:.|..:.: ||.|
  Fly   267 DSTQQVDEQSE---------SAANATATAESVESEAEPEEEDDDVCSSQSSDTLVDLPGLRRVQR 322

Human   611 -------DSGSECLLVHVLQLKNPAGLAVKEDCK--VHIRVYLPPLDSGTPNT-----YCSKALE 661
                   .:.:|.|...|:||.:.. :.::.|.:  :|..|....|.:.|.|:     |..:.|
  Fly   323 LLFGCQIRAITEKLTSSVIQLSDWV-IYMRTDWERVIHCLVICFDLATNTNNSVVDMDYLDRVL- 385

Human   662 FQVPLVFNEVFRIPVHSSALTLKSLQLYVCSVTPQLQEELLGIAQINLADYDSLSEMQLRWHSVQ 726
               |.:......:||.:.|   :..:::....:.|| ..|:...|..:              ::|
  Fly   386 ---PKLCQAASAMPVPAQA---RLARIWAAHCSDQL-HSLIAACQQQI--------------TLQ 429

Human   727 VFTSSEPSRTREAGCAG-------------ESSARDPAHTISISGKTDAVTVLLARTTAQLQAVE 778
            |....|..|..|:..:.             .|....|:..:.:..:|:|.|   |..:|   |||
  Fly   430 VLLDEESMRENESIISVTKVLKIVFYANILASELERPSCRVPLEDRTEAAT---ASGSA---AVE 488

Human   779 RELAEERAKLE-----YTEEEVLEMERKEEQAEAISER 811
            .:|....:.||     :.|::.    .||.|..||..|
  Fly   489 DDLFVYNSLLEPHMPKFAEDQF----EKELQVSAIDCR 522

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
WWC3	NP_056506.2	THOC7	<4..119	CDD:283305
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	363..384		7/19 (37%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	422..488		11/65 (17%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	510..544		4/33 (12%)
		C2_Kibra	602..725	CDD:176062	24/140 (17%)
Ube3a	NP_648452.1	AZUL	40..94	CDD:293166
		HECTc	620..971	CDD:238033
		HECTc	647..970	CDD:214523
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_COG5021
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	1	0.900