DRSC/TRiP Functional Genomics Resources

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back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits


Protein Alignment WWC3 and Magi

DIOPT Version :9

Sequence 1:NP_056506.2 Gene:WWC3 / 55841 HGNCID:29237 Length:1092 Species:Homo sapiens
Sequence 2:NP_001286661.1 Gene:Magi / 37403 FlyBaseID:FBgn0034590 Length:1202 Species:Drosophila melanogaster


Alignment Length:928 Identity:172/928 - (18%)
Similarity:292/928 - (31%) Gaps:343/928 - (36%)


- Green bases have known domain annotations that are detailed below.


Human     1 MDHINKLTQIEDPREQWRREQERMLKEYLIVAQEALNAKKEIYQIKQQRFELAQEEYQQLHKMCE 65
            :||:|:.||.|:|                     .|.||:...:..||:    |:..||..:|.|
  Fly   358 IDHVNRRTQYENP---------------------VLEAKRRAAEQSQQQ----QQMQQQQQQMQE 397

Human    66 DDSRSYASSFSGYSTNTKYDPHQIKAEIASRRDRLSRLKRELTQMKQELQYKEKGVETLQEIDRK 130
            ..|:: .::.|........:.|:.:.:     :...:|..:.|:...|||.:.... ||.:..|.
  Fly   398 QRSKT-PTALSETMPTEAAEAHEQEED-----ESPMKLPYKFTRNPAELQGQRINT-TLLKSSRG 455

Human   131 MSSTHTSYKLDEAQAIMSELRTIKKAI------CTGEKERRDLMHSLAKLTDSFKNSCSVTDSLV 189
            :..|..... ..|...:.|...||..:      ..|:.:..|::             ..|.|:.|
  Fly   456 LGFTIVGSD-GSAGGDVEEFLQIKTVVPNGPAWLDGQLQTGDVL-------------VYVNDTCV 506

Human   190 -DFPHHVGV-------PGD-------AGVPQQFCDAGSQTDIIGEFVFD----DKTRLVDRVRLN 235
             .:.||..|       ||:       .|.|..|......|:::.....|    ||.|   |:.::
  Fly   507 LGYTHHDMVNIFQSILPGERAALEVCRGYPLPFDPNDPNTEVVTTMAVDGRESDKQR---RLNMD 568

Human   236 WQYE------EARKRVA-----------------NIQQ---------------QLAR--LDNESW 260
            ..|.      |..|:.:                 :|.:               |:.:  ||....
  Fly   569 GNYNFLDLSGEGAKKTSGSGSGFILMKKPEIYTFSIMKGSMGFGFTIADSACGQIVKKILDRNCC 633

Human   261 PSTAEAD----------RDR-----LQLIKEKEALLQELQLI------------IAQRRSAGDVA 298
            ....|.|          |::     ::|:||..........|            :||....|:||
  Fly   634 TQLMEGDVLLEINGLNVRNKPHFYVVELLKECSQTTPTAVKIQRTPPDPPANNTLAQLNQVGNVA 698

Human   299 RLEEE-----------------RERLEEEL-----------RRAR----------------ATSA 319
            :|.:.                 ..:::|.|           ||:|                |.:|
  Fly   699 KLRKNFVGSGLFRSKTPTADLYSTQVKEVLPMRPKTPLVDTRRSRVQIQSPNNEVDDEGDGAAAA 763

Human   320 QGATERILLQEKRNCLLMQLEEATRLTSYLQSQLKSLCASTLTVSSGSSRGSLASSRGSLASSRG 384
            :....::..|.|.|..|.:|::...:..|.:....|...:.:|:...::.|              
  Fly   764 ERKPLQLQTQGKSNSSLQELDDIPYMDPYPKISRLSERLAEVTLQGDANGG-------------- 814

Human   385 SLSSVSFTDIYGLPQYEKPDAEGSQLLRFDLIPFDSLGRDAPF----------------SEPPGP 433
                     |||:|...:|            :|......::.:                ::....
  Fly   815 ---------IYGMPPSMQP------------LPLPLAHHESCYCYDCQAQRYRPGYFVQAQQAAM 858

Human   434 SGFHKQRRSLDTP-----------QSLASLSSRSSLSSLSPPSSPLDTP------FLPASRDSPL 481
            ||...|...|.|.           ..|.|...|...::|.||.....:|      .|..|.|   
  Fly   859 SGTTGQYSPLQTAHLQNERIQRRVNELLSDRRRVGFANLDPPQQMQHSPSWRNGALLDVSED--- 920

Human   482 AQLADSCEGPGLGALDRLRAHASAM--------GDEDLPGMAALQPHGVPGDGEGPHER------ 532
               ||.||      |..:.....|:        |.|:  |......|.|||......:|      
  Fly   921 ---ADQCE------LTEVTLERQALGFGFRIVGGTEE--GSQVTVGHIVPGGAADQDQRINTGDE 974

Human   533 -----GPPPASAPVGGTVTLREDSAKR-----LERRARR-------ISACLSDYSLASDSGVFEP 580
                 |....::.....|:|..:||.|     :.||.|.       :|..|..|.       ::.
  Fly   975 ILSIDGINVLNSSHHKVVSLVGESALRGQVTMILRRRRTPLLQQAPVSTQLRRYP-------YDV 1032

Human   581 LTKRNED---------AEEPAYGDTASN---GDPQIHVGLLRDSGSECLLVHVLQLKNPAGLA-- 631
            :..|:|:         :....||.|...   |.|....|.|: .|...:.|:.:::   ||::  
  Fly  1033 IVSRHENEGFGFVIISSSNHYYGSTIGKLIPGSPADRCGELK-VGDRIVAVNRIEI---AGMSHG 1093

Human   632 -----VKEDCKVHIRVYL-PPLDSGTPNTYCSKALEFQVPLVFNEVFRIPVHSSALTLKSLQLYV 690
                 :||. .:|:|:.: .||..|.|:...|     .|.:..|    .|:.:|...||: ||  
  Fly  1094 DVVNLIKES-GLHVRLTIGVPLKEGGPSPGGS-----SVGVSSN----TPLQASPSLLKA-QL-- 1145

Human   691 CSVTPQLQEELLGIAQIN 708
             |...||.::.|..||:|
  Fly  1146 -SHQQQLPQQHLQQAQLN 1162

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
WWC3NP_056506.2 THOC7 <4..119 CDD:283305 23/114 (20%)
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 363..384 1/20 (5%)
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 422..488 17/98 (17%)
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 510..544 7/44 (16%)
C2_Kibra 602..725 CDD:176062 31/115 (27%)
MagiNP_001286661.1 WW 294..323 CDD:278809
WW 342..372 CDD:238122 7/34 (21%)
PDZ 443..534 CDD:214570 18/105 (17%)
DegQ <455..534 CDD:223343 15/92 (16%)
PDZ_signaling 606..668 CDD:238492 9/61 (15%)
PDZ 925..1011 CDD:214570 18/93 (19%)
PDZ_signaling 1029..1110 CDD:238492 17/92 (18%)
Blue background indicates that the domain is not in the aligned region.


Information from Original Tools:


Tool Simple Score Weighted Score Original Tool Information
BLAST Result Score Score Type Cluster ID
Compara 00.000 Not matched by this tool.
Domainoid 00.000 Not matched by this tool.
eggNOG 1 0.900 - - E1_COG5021
Hieranoid 00.000 Not matched by this tool.
Homologene 00.000 Not matched by this tool.
Inparanoid 00.000 Not matched by this tool.
Isobase 00.000 Not matched by this tool.
OMA 00.000 Not matched by this tool.
OrthoDB 00.000 Not matched by this tool.
OrthoFinder 00.000 Not matched by this tool.
OrthoInspector 00.000 Not matched by this tool.
orthoMCL 00.000 Not matched by this tool.
Panther 00.000 Not matched by this tool.
Phylome 00.000 Not matched by this tool.
RoundUp 00.000 Not matched by this tool.
SonicParanoid 00.000 Not matched by this tool.
SwiftOrtho 00.000 Not matched by this tool.
TreeFam 00.000 Not matched by this tool.
User_Submission 00.000 Not matched by this tool.
10.900

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