Protein Alignment WWC3 and Smurf

DIOPT Version :9

• Sequence 1: NP_056506.2
• Gene: WWC3 / 55841
• HGNCID: 29237
• Length: 1092
• Species: Homo sapiens
• Sequence 2: NP_001261061.1
• Gene: Smurf / 36999
• FlyBaseID: FBgn0029006
• Length: 1061
• Species: Drosophila melanogaster
• Alignment Length: 540
• Identity: 104/540 - (19%)
• Similarity: 169/540 - (31%)
• Gaps: 199/540 - (36%)

Human     1 MDHINKLTQIEDPR------EQWRR---------------------------------------- 19
            :||.|:.||..|||      :..||
  Fly   580 VDHNNRTTQFTDPRLSGSILQMIRRGTVPPTSAANAGTPAPPSATPATPSAAAAVPPQATPASNA 644

Human    20 ------------------------EQERMLKEY---LIVAQEALNAKKEIYQ-------IKQQRF 50
                                    |...:|.:|   |:....||..:.:..|       ::..|.
  Fly   645 TPTTLTTTTNPPHRIVPDLPQGLLEGADLLPKYRRDLVGKLRALRTELQTMQPQSGHCRLEVSRN 709

Human    51 ELAQEEYQQLHKMCEDDSRS-YASSFSGYSTNTKYDPHQIKAEIASRRDRLSRLKRELTQMKQEL 114
            |:.:|.|:.:.||...|.|. ....|.| .....|.        ...|:.|..|.||:...:..|
  Fly   710 EIFEESYRLIMKMRAKDMRKRLMVKFKG-EEGLDYG--------GVAREWLHLLSREMLNPQYGL 765

Human   115 -QYKEKGVETLQ-EIDRKMSSTHTSY----------------KLDEAQAIMSELRTIKKAICTGE 161
             ||......||| ..|..::..|.||                .||.........:.:.|.|..|:
  Fly   766 FQYSRDDHYTLQINPDSGVNPDHLSYFHFVGRTLGIAVFHGHCLDGGFTTPFYKQLLNKPITLGD 830

Human   162 KE--RRDLMHSLAKLTDSFKNSCSVTDSLVDFPH--------HVGVPGDAGVPQQFCDAGSQTDI 216
            .|  ..||..||..:.:|  |...:.:|.....:        |...||.|.:|
  Fly   831 IEGVDPDLHRSLTWMLES--NISGIIESTFSVENNSFGALVVHELKPGGASIP------------ 881

Human   217 IGEFVFDDKTRLVDRVRLNWQYEEARKRVANIQQQLARLDN---ESWPSTAEADRDRLQLIKEKE 278
                |.::..|...::.:|:::      :..|:||...|..   |..||         .|::..:
  Fly   882 ----VTEENKREYVKLYVNYRF------MRGIEQQFLALQKGFCELIPS---------HLLRPFD 927

Human   279 ALLQELQLIIAQRRSAGDVARLEEERERLEEELRRARATSAQGATERILLQEKRNCLLMQLEEAT 343
            .  :||:|:|      |.::.::....|....|                    ::|    ..|.|
  Fly   928 E--RELELVI------GGISSIDVNDWRNNTRL--------------------KHC----TNETT 960

Human   344 RLTSY---LQSQLKSLCASTLTVSSGSSRGSLASSRGSLASSRGSLSSVSFT-----DIYGLPQY 400
            ::..:   ::|....:.|..|...:||||..|...| :|..|.|::....||     |:   |..
  Fly   961 QVLWFWQVVESYSSEMRARLLQFVTGSSRVPLQGFR-ALQGSTGAVGPRLFTIHLTADV---PTQ 1021

Human   401 EKPDAEGSQLLRFDLIPFDS 420
            ..|.|. :...|.||.|:::
  Fly  1022 NLPKAH-TCFNRIDLPPYET 1040

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
WWC3	NP_056506.2	THOC7	<4..119	CDD:283305	34/196 (17%)
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	363..384		8/20 (40%)
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	422..488
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	510..544
		C2_Kibra	602..725	CDD:176062
Smurf	NP_001261061.1	C2_Smurf-like	14..135	CDD:176028
		WW	169..198	CDD:278809
		WW	514..546	CDD:197736
		WW	562..594	CDD:197736	7/13 (54%)
		HECTc	702..1058	CDD:238033	87/418 (21%)
		HECTc	726..1058	CDD:214523	81/394 (21%)

Information from Original Tools

Tool	Simple Score	Weighted Score	Original Tool Information
			BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_COG5021
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	1	0.900