DRSC/TRiP Functional Genomics Resources

powered by:
logo

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits


Protein Alignment WWC3 and Ufd4

DIOPT Version :9

Sequence 1:NP_056506.2 Gene:WWC3 / 55841 HGNCID:29237 Length:1092 Species:Homo sapiens
Sequence 2:NP_609369.1 Gene:Ufd4 / 34378 FlyBaseID:FBgn0032208 Length:2727 Species:Drosophila melanogaster


Alignment Length:1176 Identity:208/1176 - (17%)
Similarity:374/1176 - (31%) Gaps:426/1176 - (36%)


- Green bases have known domain annotations that are detailed below.


Human    17 WRREQERMLKEYLIVAQEALNAKKEIYQIKQQRFELAQEEYQQLHKMCEDDSRSYASSFSGYSTN 81
            |.|        ::.:.|...||..:.:.:....||:    |.::..:.:|..:|..         
  Fly  1267 WYR--------HIRIQQNGRNASGQTHYLSLSGFEI----YGRVVGVADDIGKSVK--------- 1310

Human    82 TKYDPHQIKAEIASRRDRLSRLKRELTQMKQELQYKEKGVETLQEIDRKMSSTHTSYKLDEAQ-- 144
                    :||..:||:|        .|::.:|::...|...::.:|         ::.:|..  
  Fly  1311 --------EAEAKTRRER--------RQIRAQLKHMTTGARVIRGVD---------WRWEEQDGC 1350

Human   145 ---AIMSELRT----------IKKAICTGEKERRDLMHSLAKLTDSFKNSCSVTDSLVDFPHHVG 196
               .|..|:..          ::.:...|.:.:.||     ||.|     |... |..|....:|
  Fly  1351 AEGTITGEIHNGWIDVKWDHGVRNSYRMGAEGKYDL-----KLAD-----CEYL-SAFDGNQSMG 1404

Human   197 VPGDAGVPQQFCDAGSQTDIIGEFVFDDKTRLVDRVRLNW-QYEEARKRVAN---IQQQLARLDN 257
            ....|..|.   :.|..|             |..|...:. ...||.::..|   ...|....||
  Fly  1405 SASTAAKPS---EKGGNT-------------LTSRKSSSTPSLPEATEKNQNPEGASNQTVSADN 1453

Human   258 ESWPSTAEADRDRLQLIKEKEALLQELQLI---IAQRRSAGDVARLEEERERLEEELRRARATSA 319
            .:|..|.|.       |.|......:.|:|   :|...|:.                |.|||...
  Fly  1454 LAWKQTVET-------IAENVFASAKTQIISNQLAMNTSSS----------------REARAKHK 1495

Human   320 QGATERILLQEKRNC-----LLMQLEEATRLTSYLQSQLKSLCASTLTVSSGSSRGSLASSRGSL 379
            :..|.::   .|.|.     |..:||..:.|         |...:::...:.|:...||:...:|
  Fly  1496 ESGTNQM---HKDNISGPSPLSRELEHISDL---------SAINNSMPAINSSNVSDLATISENL 1548

Human   380 ASSRGSLSSVSFTDIYGL--PQYEKPDAEGSQLLRFDLIPFDSLGRDAPFSEPPGPSGFHKQR-- 440
                 ||:.:|..:|..:  |.|:               |.:|:......|.|...|...::.  
  Fly  1549 -----SLTELSKENICRVLTPSYK---------------PAESVTASQSSSHPDVQSSSPRENDI 1593

Human   441 RSLDTPQSLASLSSRSSLSSLS---------------PPSSPLDTPFLPASRDSPLAQLADSCEG 490
            :::...:....:::.:|::.:|               ||.:.|.|..|         ::.|... 
  Fly  1594 KNISNIEENNKMNANNSVNKISKDLLANLRTSNIAGCPPVTQLSTEAL---------EMIDKMR- 1648

Human   491 PGLGALDRLRAHA-SAMGDEDLPGMAALQPHGVPGDGEGPHERGPPPASAPVGGTVT------LR 548
               ..:|.:|..: |.:..:..|                     .|..:.||||..|      :.
  Fly  1649 ---DGVDMIRNMSNSILSTDTFP---------------------VPCTNVPVGGKKTPKAQALIN 1689

Human   549 EDSAKRLE--------------------RRARRISACLS------------DYSLASDSGVFEPL 581
            .|:|.:.:                    :.|::.:|.||            :.|:.|...:..|.
  Fly  1690 PDNANQKQIIVTSEEFPTKSSKKPSVTLKPAQQPNAVLSIVDIKEQPISNENVSVPSQMSISVPN 1754

Human   582 TKRNEDAEEPAYGDTASNGDPQIHVGLLRDSGSECLLVHVLQLKNPAGLAVKE----DCKVHIRV 642
            ......:|.|:..:.|:      |.|||....:      :.:.:...|..:::    :.:.::..
  Fly  1755 LTTTSASEVPSTSEVAT------HTGLLETFAA------IARRRTSQGTNIQDNQIMNAEANVNE 1807

Human   643 YLPPLDSGTPNTYCSKALEFQVPLVFNEVFRIPVHSSALTLKSLQLYVCSVTPQLQEELLGIAQI 707
            :   .|.....::...::...|.|..:..|    ||.                     ||..|| 
  Fly  1808 H---GDQNASGSFLGHSVTSLVKLALSSNF----HSG---------------------LLSTAQ- 1843

Human   708 NLADYDSLSEMQLRWHSVQVFTSSEPSRTREAGCAGESSARDPAHTISI---SGKTDAVTVLL-- 767
               .|.|||.     ::.:....|.||.|    .||:.||....||:::   |..:|:..|.|  
  Fly  1844 ---SYPSLSS-----NNSENIAPSNPSNT----SAGQQSASTINHTLTMSLTSTSSDSEQVSLED 1896

Human   768 ----ARTTAQL------QAVERELAEERAKLEYTEEEV----------------LEMERKEEQAE 806
                .|..|.|      ..::.:..||..:.||  |||                ::.|..|.:..
  Fly  1897 FLESCRAPALLGDLDDEDDMDEDNDEEENEDEY--EEVGNTLLQVMVSRNLLTFMDDEAMENRLV 1959

Human   807 AISER-SWQADSV--------------DSGCSNCTQTSPPYPEPCCMGIDSILGHPFAAQAGPYS 856
            .:::| ||..:.|              ..|.:|..|||.....|  :|.:.    |...|:|  .
  Fly  1960 GVTKRKSWDDEFVLKRQFSALIPAFDPRPGRTNVNQTSDLEISP--LGAEL----PKPQQSG--G 2016

Human   857 PEKFQPSPL----------------KVDKETNTEDLF-----LEEAASLVKERPSRR-------- 892
            ||..: .||                ::|.......:|     |.:.:.|.|....|:        
  Fly  2017 PETIE-QPLLGLKLRGPGIGGIPEVEIDLSNTDWTIFRAVQELLQCSQLNKLDKFRKIWEPTYTI 2080

Human   893 --ARGSPFVRSGTIVRSQTF--SPGARSQYVCRLYRSDSDSSTLPRKSPF------VRNTLERRT 947
              ...||..:..|.:.|:.|  :|...|:         |.:|||...||.      ..|.|    
  Fly  2081 VYREVSPEAQESTCLESEEFPQTPDVSSK---------SGASTLSPNSPMHIGFNVADNNL---- 2132

Human   948 LRYKQSCR-SSLAELMARTS--LDLELDLQASRTRQRQLNEELCALR----ELRQRLEDAQLRGQ 1005
                  |. ..:.||:.:.:  ...|:|..........|:|:|...:    :|:|:::|..:...
  Fly  2133 ------CSVDDVLELLTQINGLNQSEIDSDVKEHGVSVLSEDLFISKKITNKLQQQIQDPLVLAS 2191

Human  1006 TDLPPW 1011
            ..||.|
  Fly  2192 NALPNW 2197

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
WWC3NP_056506.2 THOC7 <4..119 CDD:283305 17/101 (17%)
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 363..384 4/20 (20%)
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 422..488 11/82 (13%)
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 510..544 5/33 (15%)
C2_Kibra 602..725 CDD:176062 19/126 (15%)
Ufd4NP_609369.1 ANK repeat 393..420 CDD:293786
ANK 396..509 CDD:238125
ANK repeat 422..453 CDD:293786
ANK repeat 455..484 CDD:293786
F5_F8_type_C 1173..1298 CDD:329041 8/42 (19%)
MIB_HERC2 1333..1389 CDD:310955 9/69 (13%)
DamX 1576..>1725 CDD:330571 24/182 (13%)
HECTc 2265..2725 CDD:238033
Blue background indicates that the domain is not in the aligned region.


Information from Original Tools:


Tool Simple Score Weighted Score Original Tool Information
BLAST Result Score Score Type Cluster ID
Compara 00.000 Not matched by this tool.
Domainoid 00.000 Not matched by this tool.
eggNOG 1 0.900 - - E1_COG5021
Hieranoid 00.000 Not matched by this tool.
Homologene 00.000 Not matched by this tool.
Inparanoid 00.000 Not matched by this tool.
Isobase 00.000 Not matched by this tool.
OMA 00.000 Not matched by this tool.
OrthoDB 00.000 Not matched by this tool.
OrthoFinder 00.000 Not matched by this tool.
OrthoInspector 00.000 Not matched by this tool.
orthoMCL 00.000 Not matched by this tool.
Panther 00.000 Not matched by this tool.
Phylome 00.000 Not matched by this tool.
RoundUp 00.000 Not matched by this tool.
SonicParanoid 00.000 Not matched by this tool.
SwiftOrtho 00.000 Not matched by this tool.
TreeFam 00.000 Not matched by this tool.
User_Submission 00.000 Not matched by this tool.
10.900

Return to query results.
Submit another query.