DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment WWC3 and CG4238

DIOPT Version :9

Sequence 1:	NP_056506.2	Gene:	WWC3 / 55841	HGNCID:	29237	Length:	1092	Species:	Homo sapiens
Sequence 2:	NP_001259896.1	Gene:	CG4238 / 33377	FlyBaseID:	FBgn0031384	Length:	977	Species:	Drosophila melanogaster

Alignment Length:	924	Identity:	185/924 - (20%)
Similarity:	295/924 - (31%)	Gaps:	333/924 - (36%)

- Green bases have known domain annotations that are detailed below.

Human   256 DNESWPSTAEADRDRLQLIKEKEALLQELQLIIA------------QRRSAGDVARLEEERERLE 308
            |.|..|.....|..|||    :.||..:.:||:.            ||..|.:||.||:     .
  Fly    84 DPERLPELPPLDEQRLQ----RAALHLQQKLILREWLKDHRLQHHYQRLLAVEVASLED-----V 139

Human   309 EELRRARATSAQGATERILLQEKRNCLLMQLEEATRLTSYLQSQLKSLCAST-----------LT 362
            ..|..:||:...|...::....::|     |..:......|::||.|....:           :.
  Fly   140 YWLEDSRASKILGKDWQLWSGARQN-----LPTSKAQLDALKAQLWSTVVKSSQHQDAWTWGGML 199

Human   363 VSSGSSRGSL---ASSRGSLA-SSRGSLSSVSFTDIYGLP-------QYEKPDAEGSQL---LRF 413
            |.|.|..|.:   |.::.||| .:|.||... .|..|.||       .::.|.:.|..:   :||
  Fly   200 VVSVSVAGLVTLAAMTQPSLAPEARHSLLQY-VTGKYLLPANCKVQWDWKDPASVGGTMCFVVRF 263

Human   414 DLIPFDSLGRDAPF-------------------------SEPPGPSGFHKQRRSLDT--PQSLAS 451
                |...|:..|.                         |..|..:...|.:.::.|  ...::.
  Fly   264 ----FQRNGQPYPICDTDHFFVEVTEGTRKVVTISELGSSTDPNNANIAKVKFTVRTAGQYKISV 324

Human   452 LSSRSSLSSLSPPSSPLDTPFLPASRDS-------------------------PLAQLADSCEGP 491
            |...|.::     .||....|||.:.|:                         |..:..:||
  Fly   325 LIGASHIA-----GSPFLRSFLPGAIDARRSRFIRPASTVICCAGAPTLMHIEPRDEFGNSC--- 381

Human   492 GLGALDRLRAHASAMGDEDLPG--MAALQPHGVPGDGEGPHERGPPPASAPVGGTVTLREDSAKR 554
               ..|:.::      ||.|.|  :|....||||                            .::
  Fly   382 ---LFDQNQS------DEALQGYQVAIYDLHGVP----------------------------VEK 409

Human   555 LERRARRISACLSDY----SLASDSGVF-EPLTKR----NEDAEEPAYGDTASNGDPQIHVGLLR 610
            |:.      |.:..|    |..|.:.:| ||...|    ..|.:.|       |||..|.|
  Fly   410 LQH------AIVFAYDKVNSRVSVTALFPEPTCLRAVISYRDQQLP-------NGDFDIIV---- 457

Human   611 DSGSECLLVHVLQLKNPAGLAVKEDCKVHIRVYLPPLDS--GTPNTYCSKALEFQVPLVFNEVFR 673
            .|.|:..|||    ||.|.       :.|...|...|.|  |.......|.|.:..|...:.:|:
  Fly   458 LSSSDTTLVH----KNIAS-------RKHNICYEAKLLSIFGVSKNKPRKVLCYVGPKQNSLIFQ 511

Human   674 IPVHSSALTL--KSLQLY-VCSVT-----PQLQEELLGIAQINLADYDSLSEMQLRWHSVQVFTS 730
            :.:....|..  |.:..: :|..|     |||..:|.|  .:.:.|..:..:::|
  Fly   512 VTIKEMILKFIPKRIATFRLCPSTKFHFLPQLVSQLHG--PVFIIDDGAQPKIEL---------- 564

Human   731 SEPSRTREAGCA-----------GESSARDPAHTISISGKTDAVTVLLARTTAQLQAVERELAEE 784
              .|:.|....|           |..:.:|         |.|..       ..:::........|
  Fly   565 --ASKDRNIIAATFTHFLLKNIGGSETFKD---------KQDFF-------YHEVRKFHASYYHE 611

Human   785 RAKLEYTEEEVLEMERKEEQAEAISERSWQADSVDSGCSNCTQTSPPYPEPCCMGID-------- 841
            :..|:...|::||...|..:..::|:  |        |.|...|....     .|||
  Fly   612 KMALKVQREKILESSMKAVKGFSVSD--W--------CGNFEVTFQGE-----QGIDWGGLRREW 661

Human   842 --SILGHPFAAQAGPY-----------SPEKFQPSPLKVDKETNTEDLFLEEAASLVKE------ 887
              .:....|.|:.|.:           .|...:|:.||:.        ..|.|..:|.:
  Fly   662 FELVCSALFDARGGLFCTFHDKHQALVHPNPTRPAHLKLK--------HFEFAGKMVGKCLFESA 718

Human   888 -----RPSRRARGSPFVRS------GTIVRSQTFSPGARSQYVCRL-YRSDSDSSTLPRKSPFVR 940
                 |...|||   |.||      |..|..:.|.......|:.:: |..|:|..        ..
  Fly   719 LGGTYRQLVRAR---FSRSFLAQLIGLRVHYKYFEQDDPDLYLSKIKYILDTDLD--------AT 772

Human   941 NTLERRTLRYKQSCRSSLAELMARTSLDLELDLQASRTR--QRQLNEELCALRELRQRL------ 997
            :|||   |.:.:....|.:..:::|   :||....::||  ....|:.|.||.:  |||
  Fly   773 DTLE---LYFVEEMYDSSSGQLSKT---IELIPNGAKTRVTNATKNQYLDALAQ--QRLCNNVKD 829

Human   998 -EDAQLRGQTDLPP 1010
             .|:.|:|...:.|
  Fly   830 EVDSFLKGLNSIIP 843

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
WWC3	NP_056506.2	THOC7	<4..119	CDD:283305
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	363..384		8/24 (33%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	422..488		15/117 (13%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	510..544		7/35 (20%)
		C2_Kibra	602..725	CDD:176062	30/132 (23%)
CG4238	NP_001259896.1	IG_FLMN	238..336	CDD:214720	15/106 (14%)
		Filamin	238..336	CDD:279024	15/106 (14%)
		HECTc	615..975	CDD:238033	58/271 (21%)
		HECTc	642..974	CDD:214523	49/234 (21%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_COG5021
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	1	0.900