DRSC/TRiP Functional Genomics Resources

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back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits


Protein Alignment WWC3 and pub1

DIOPT Version :9

Sequence 1:NP_056506.2 Gene:WWC3 / 55841 HGNCID:29237 Length:1092 Species:Homo sapiens
Sequence 2:NP_594396.1 Gene:pub1 / 2541818 PomBaseID:SPAC11G7.02 Length:767 Species:Schizosaccharomyces pombe


Alignment Length:405 Identity:72/405 - (17%)
Similarity:128/405 - (31%) Gaps:129/405 - (31%)


- Green bases have known domain annotations that are detailed below.


Human   670 EVFRIPVHSSALTLKSLQLYVC-----SVTPQLQEELLGIAQINLADYDSLSEMQLRWHSVQVFT 729
            :|||.|...:.||:...|.:..     ::.|...|..    ::|:.|..::        ::||| 
pombe    24 DVFRFPDPFAVLTVDGEQTHTTTAIKKTLNPYWNETF----EVNVTDNSTI--------AIQVF- 75

Human   730 SSEPSRTREAGCAGESSAR-DPAHTISISG---------KTDAVTVLLAR------TTAQ--LQA 776
            ..:..:.:..|..|..:.| .....::|.|         |::..||:..:      ||||  ||.
pombe    76 DQKKFKKKGQGFLGVINLRVGDVLDLAIGGDEMLTRDLKKSNENTVVHGKIIINLSTTAQSTLQV 140

Human   777 VERELAEERAKLEYTEEEVLEMERKEEQAEAISERSWQADSVDSGCSNCTQTSPPYPEPCCM--- 838
            .....:..|     |:...:..:.:..|:.::|.....:.:......|....||...||...   
pombe   141 PSSAASGAR-----TQRTSITNDPQSSQSSSVSRNPASSRAGSPTRDNAPAASPASSEPRTFSSF 200

Human   839 ------------------------------------GIDSILG------HPFAAQAGPYSPEKFQ 861
                                                .:.|:.|      |..|:.|.  ..|..|
pombe   201 EDQYGRLPPGWERRTDNLGRTYYVDHNTRSTTWIRPNLSSVAGAAAAELHSSASSAN--VTEGVQ 263

Human   862 PSPLKVDKETNTEDLFLEEAASLVKERP---SRR--ARGSP-FVRSGTIVRSQTFSPGARSQYV- 919
            ||.....:.|....|......:...|.|   .:|  ..|.| ||...|  |:.|:....|.||: 
pombe   264 PSSSNAARRTEASVLTSNATTAGSGELPPGWEQRYTPEGRPYFVDHNT--RTTTWVDPRRQQYIR 326

Human   920 --------------------------------CRLYRSDSDSSTLPRKSPFVRNTLERRTLRYKQ 952
                                            .|:|..|.::.|.....|.:.::|::...:||:
pombe   327 SYGGPNNATIQQQPVSQLGPLPSGWEMRLTNTARVYFVDHNTKTTTWDDPRLPSSLDQNVPQYKR 391

Human   953 SCRSSLAELMARTSL 967
            ..|..|...:::.:|
pombe   392 DFRRKLIYFLSQPAL 406

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
WWC3NP_056506.2 THOC7 <4..119 CDD:283305
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 363..384
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 422..488
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 510..544
C2_Kibra 602..725 CDD:176062 11/59 (19%)
pub1NP_594396.1 HUL4 1..767 CDD:227354 72/405 (18%)
C2_Smurf-like 9..131 CDD:176028 22/119 (18%)
WW 207..236 CDD:278809 0/28 (0%)
WW 290..319 CDD:278809 9/30 (30%)
WW 346..378 CDD:197736 5/31 (16%)
HECTc 413..765 CDD:238033
Blue background indicates that the domain is not in the aligned region.


Information from Original Tools:


Tool Simple Score Weighted Score Original Tool Information
BLAST Result Score Score Type Cluster ID
Domainoid 00.000 Not matched by this tool.
eggNOG 1 0.900 - - E1_COG5021
Hieranoid 00.000 Not matched by this tool.
Homologene 00.000 Not matched by this tool.
Inparanoid 00.000 Not matched by this tool.
OMA 00.000 Not matched by this tool.
OrthoFinder 00.000 Not matched by this tool.
OrthoInspector 00.000 Not matched by this tool.
orthoMCL 00.000 Not matched by this tool.
Panther 00.000 Not matched by this tool.
Phylome 00.000 Not matched by this tool.
RoundUp 00.000 Not matched by this tool.
SonicParanoid 00.000 Not matched by this tool.
SwiftOrtho 00.000 Not matched by this tool.
TreeFam 00.000 Not matched by this tool.
10.900

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