DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment WWC3 and SPAC12B10.01c

DIOPT Version :9

Sequence 1:	NP_056506.2	Gene:	WWC3 / 55841	HGNCID:	29237	Length:	1092	Species:	Homo sapiens
Sequence 2:	NP_594633.2	Gene:	SPAC12B10.01c / 2541575	PomBaseID:	SPAC12B10.01c	Length:	1647	Species:	Schizosaccharomyces pombe

Alignment Length:	781	Identity:	146/781 - (18%)
Similarity:	269/781 - (34%)	Gaps:	214/781 - (27%)

- Green bases have known domain annotations that are detailed below.

Human    36 LNAKKEIYQIKQQRFELAQEEYQQLH---KMCEDDSRSYASSFSGYSTNTKYD-PHQIKAEIASR 96
            ||..:|:...|::|   |.:.:.::.   |:.|..| |.:..| |...|.::| ...::..:.:.
pombe    41 LNTSEELPFTKKRR---ATKHFLKMEVSAKISEPPS-SKSVEF-GRHLNMRHDFSELLEQPLTTS 100

Human    97 RDRLSRLKRELTQMKQELQYKEKGV-------ETLQEIDRKMSSTHTSYKLDEAQAIMSELRTIK 154
            :.|:.:...|..:.|.:|...:|||       :.|...:|.:|:......||:...:  ::....
pombe   101 KTRVFKSFNEKLKGKPQLVKSDKGVLPLNKQSDILNSYERVLSNASVDSALDKKAEV--DIIPFD 163

Human   155 KAICTGEKERRDLMHSLAKLTDSFKNSCSVTDSLVDFPHHVGVPGDAGVPQQFCDAGSQTDIIGE 219
            |::...:....:....|.|..:|.....:.:||   ..:|....            .||.:...:
pombe   164 KSVMEPKNITFNDKSGLTKFGNSNSYETTYSDS---SNYHTSTD------------SSQYNDQDD 213

Human   220 FVFDDKTRLVDRVRLNWQYEEARKRVANIQQQLARLDNESWPSTAEADRDRLQLIKEKEALLQEL 284
            .|:||.....|....|.:|:                |:||...:...:||  :.:.|:|....:
pombe   214 HVYDDTNDGTDDDINNNEYK----------------DDESSSGSESYERD--EDVDEEEEEDDD- 259

Human   285 QLIIAQRRSAGDVARLEEERERLEEELRRARATSAQGATERILLQEKRNCLLMQLEE--ATRLTS 347
                 :....||     :|.|...:|||....:....|.   ::.|:.|..:..:||  .|.|.:
pombe   260 -----ENNDEGD-----DEDENENDELRSENGSPNPSAA---VINEQENMNMSGIEEYDETNLLN 311

Human   348 YLQSQLKSLCASTLTVSSGSSRGSLASSRGSLASSRGSLSSVSFTDIYGLPQYEKPDAEGSQLLR 412
            .|.           .:..|:...|||||    ..|.|:|.:....|:          :.|.|..|
pombe   312 ELG-----------RIRRGNQFQSLASS----ILSSGNLENSDDEDV----------SLGPQTYR 351

Human   413 FDLIPFDSLGRDAPFSEPPGPSGFHKQRRSLDTP--------QSLASLSSRS----SLSSLSPPS 465
            |:                   |.||..|.:...|        :.:...|..:    ||..||...
pombe   352 FN-------------------SSFHPFRSAFSAPGVQFGRLLEGIKDFSDPTVQMLSLQELSEAF 397

Human   466 SPLDTPFLPA--SRDSPLAQLADSCEGP----GLGALDRLRAHASAMGD--EDLP-GMAALQPHG 521
            :......|..  |.||.:|..::...|.    |..::..:.:..:.:.:  |.|| .||.:
pombe   398 AMSTEDMLVGLFSTDSYIAAFSEILSGRNYDFGEVSIQLMLSCTTCVSNMMEALPLCMAKI---- 458

Human   522 VPGDGEGPHERGPPPASAPVGGT----------VTLREDSAKRLERRARRISACLSDY------- 569
                           |.:|:...          :.:.|.:...|||.::....|:.::
pombe   459 ---------------AYSPIVRILCERMFDMQYIDIAEQALGVLERLSKDFGICILEHRGMLAAL 508

Human   570 ---------------SLASDSGVFEPLTKRNEDAEE---PAYGDTASNGDPQIHVGLLRDSGSEC 616
                           |||::...|  |.:.|..|.|   |...:...:.|.     ::......|
pombe   509 QYFDFFYTTVQRTAISLAANCCKF--LDESNASAAEEIIPLLSNILQSSDT-----IVVSKAYSC 566

Human   617 LLVHVLQLKNPAGL---AVKEDCKVHIRVYLPPLDSGTPNTYCSKALEFQVPLVFNEVFRIPVHS 678
            |...:..||....:   .:.||....|      :::.|.:|..:|::..||.|: :.:..:...|
pombe   567 LETIIESLKTSPNIIETIISEDLITTI------VNALTNSTSQNKSMHLQVQLL-HIISSLCQSS 624

Human   679 SALTLKSLQLYVCSVTPQLQEELLGIAQINLADYDSLSEMQLRWHS--------VQVFTSSEPSR 735
            |||.|..|...:..|   :.|.|.||...:.:....:..||..::.        ::..||..|..
pombe   625 SALILPFLNHNLPDV---MYEMLCGIPPSDTSHQADMITMQSLYYCPIELIENLLRAITSLLPKN 686

Human   736 T 736
            |
pombe   687 T 687

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
WWC3	NP_056506.2	THOC7	<4..119	CDD:283305	18/86 (21%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	363..384		7/20 (35%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	422..488		15/79 (19%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	510..544		6/34 (18%)
		C2_Kibra	602..725	CDD:176062	26/133 (20%)
SPAC12B10.01c	NP_594633.2	HECTc	1276..1645	CDD:238033
SPAC12B10.01c	NP_594633.2	HECTc	1301..1642	CDD:214523
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_COG5021
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	1	0.900