DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment WWC3 and pub3

DIOPT Version :9

Sequence 1:	NP_056506.2	Gene:	WWC3 / 55841	HGNCID:	29237	Length:	1092	Species:	Homo sapiens
Sequence 2:	NP_595793.1	Gene:	pub3 / 2539956	PomBaseID:	SPBC16E9.11c	Length:	786	Species:	Schizosaccharomyces pombe

Alignment Length:	423	Identity:	85/423 - (20%)
Similarity:	147/423 - (34%)	Gaps:	133/423 - (31%)

- Green bases have known domain annotations that are detailed below.

Human   307 LEEELRRAR--ATSAQGATERILLQEKRNCLLMQLE-EATRLTSYLQSQLKSLC--ASTLTVSSG 366
            :|:..:|.|  ..:|.|.::|.|.::.....::.:: |.|..|..::..:....  ...:||...
pombe     1 MEQGAKRVRFYIVAADGLSKRDLFRQPDPFAILTVDGEQTHTTKVIKKSVNPYWNEGFEVTVKPS 65

Human   367 S---------------SRG--SLASSR----GSLASSR-----GSLSSVSFTDIYGLPQYEKPDA 405
            |               .:|  .|.|.|    ||..|:|     ..|...|.|::..|
pombe    66 SVISIRLFDQKKFKKKDQGFLGLVSFRMREVGSFRSNREVSLTRPLKKSSTTNLSVL-------- 122

Human   406 EGSQLLRFDLIPFDSLGRDAPFSEPPGPSGFHKQ---RRSLDTPQSLASLSSRSSLSSLSPPSSP 467
             |:.:|:.           || |:...|:|.|..   .|:..||.:..:.::|::    ..|::.
pombe   123 -GNLVLKV-----------AP-SKIRAPAGNHSSTTANRTTSTPTTTTARTTRTT----PRPTAT 170

Human   468 LDTPFLPASRDSPLAQLADSCEGPGLGA-----------LDRLRAHASAMGDEDLPGMAALQPHG 521
            .:|.....|..:.....|.:..|.|.||           .:|...:.||:.:.:...|::.
pombe   171 TNTSNQSTSNSTRNGTSAATSNGTGTGAGTGASHRSSPVTNRQTNNTSALSNSNAHIMSSF---- 231

Human   522 VPGDGEGPHERGPP--------------------------PASA--PVGGTVTLREDSAKRLERR 558
                 |..:.|.||                          |||:  ||..|    ...::||..:
pombe   232 -----EDQYGRLPPGWERRADSLGRTYYVDHNTRTTTWTRPASSTNPVHNT----SSDSQRLNHQ 287

Human   559 ARRISACLSDYSLASDSGVFEPL--TKRNEDAEEPAYGD----TASNGDPQIHVGLLRDSGSECL 617
            .|.:....:...:.||||...|.  ..|..|...|.:.|    |.:..||:  ..|:|.:|....
pombe   288 NRHLPDDSNPSLMQSDSGNDLPFGWEMRYTDTGRPYFVDHNTRTTTWVDPR--NPLVRPNGGSST 350

Human   618 LVHVLQLKNPAGLAVKEDCKVHIRVYLPPLDSG 650
            :..::|   |..|:           :|.||.||
pombe   351 VGSLMQ---PQSLS-----------HLGPLPSG 369

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
WWC3	NP_056506.2	THOC7	<4..119	CDD:283305
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	363..384		10/46 (22%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	422..488		14/68 (21%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	510..544		10/61 (16%)
		C2_Kibra	602..725	CDD:176062	12/49 (24%)
pub3	NP_595793.1	HUL4	4..786	CDD:227354	84/420 (20%)
		C2_Smurf-like	7..130	CDD:176028	26/142 (18%)
		WW	238..267	CDD:278809	2/28 (7%)
		WW	308..337	CDD:278809	6/28 (21%)
		WW	365..397	CDD:197736	4/5 (80%)
		HECTc	434..784	CDD:238033
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_COG5021
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	1	0.900