DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment WWC3 and Wwc1

DIOPT Version :9

Sequence 1:	NP_056506.2	Gene:	WWC3 / 55841	HGNCID:	29237	Length:	1092	Species:	Homo sapiens
Sequence 2:	NP_740749.1	Gene:	Wwc1 / 211652	MGIID:	2388637	Length:	1104	Species:	Mus musculus

Alignment Length:	1156	Identity:	472/1156 - (40%)
Similarity:	656/1156 - (56%)	Gaps:	187/1156 - (16%)

- Green bases have known domain annotations that are detailed below.

Human     1 MDHINKLTQIEDPREQWRREQERMLKEYLIVAQEALNAKKEIYQIKQQRFELAQEEYQQLHKMCE 65
            :||..|.|||||||.|||||||.|||:||:||||||:|:|||||:||||.||||:||||||.:.|
Mouse    72 IDHNTKTTQIEDPRVQWRREQEHMLKDYLVVAQEALSAQKEIYQVKQQRLELAQQEYQQLHAVWE 136

Human    66 DDSRSYASSFSGYSTNTKYDPHQIKAEIASRRDRLSRLKRELTQMKQELQYKEKGVETLQEIDRK 130
            ....|..|..||.|:::||||..:|||||:.:.|:::||||:..::.|||:||:|.:||::||.:
Mouse   137 HKLGSQVSLVSGSSSSSKYDPEILKAEIATAKSRVNKLKREMVHLQHELQFKERGFQTLKKIDER 201

Human   131 MSSTHTSYKLDEAQAIMSELRTIKKAICTGEKERRDLMHSLAKLTDSFK-----------NSCSV 184
            ||.....||||||||::.|.:.|||||..||||::||:.|||.|.|.|:           :|.|:
Mouse   202 MSDAQGGYKLDEAQAVLRETKAIKKAITCGEKEKQDLIKSLAMLKDGFRTDRGSHSDLWSSSSSL 266

Human   185 TDSLVDFPHHVGVPGDAGVPQQFCDAGSQTDIIGEFVFDDKTRLVDRVRLNWQYEEARKRVANIQ 249
            ..|  .||          :|:||.|..|||||.|.|......:|.::|||..:||||::|:||::
Mouse   267 ESS--SFP----------MPKQFLDVSSQTDISGSFSTSSNNQLAEKVRLRLRYEEAKRRIANLK 319

Human   250 QQLARLDNESWPSTAEADRDRLQLIKEKEALLQELQLIIAQRRSAGDVARLEEERERLEEELRRA 314
            .|||:||:|:||...:::||||.||.|||.||:|::.|..::.:.|:|.:||..|.|||::|:.|
Mouse   320 IQLAKLDSEAWPGVLDSERDRLILINEKEELLKEMRFISPRKWTQGEVEQLEMARRRLEKDLQAA 384

Human   315 RATSAQGATERILLQEKRNCLLMQLEEATRLTSYLQSQLKSLCASTLTVSSGSSRGSLASSRGSL 379
            |.|.::..|||:.|..|||.|:.:||||||..:.|.||||||.:|..::|||||.|||.||||||
Mouse   385 RDTQSKALTERLKLNSKRNQLVRELEEATRQVATLHSQLKSLSSSMQSLSSGSSPGSLTSSRGSL 449

Human   380 -ASSRGSLSSVSFTDIYGLPQYEKPDAEGSQLLRFDLIPFDSLGRDAPFSEPPGPSGF------- 436
             |||..|.:|.||||:|..| :|:.|:|...  :.:|:          |.|  |.:||
Mouse   450 AASSLDSSTSASFTDLYYDP-FEQLDSELQS--KVELL----------FLE--GATGFRPSGCIT 499

Human   437 --HKQR----------------RSLD-TPQSLASLSSRSSLSSLSPPSSPLDT-PFLPASRDSPL 481
              |:..                |||. ||:|:.|||.||||||.|||.|||.| |.|  :.|:.|
Mouse   500 TIHEDEVAKTQKAEGGSRLQALRSLSGTPRSMTSLSPRSSLSSPSPPCSPLITDPLL--TGDAFL 562

Human   482 AQL--------ADSCEGPGLGALDRLRAHASAMGDEDLPGMAALQPHGVPGDGEGPHER----GP 534
            |.|        ...|| ..||                               |.|..||    .|
Mouse   563 APLEFEDTELSTTLCE-LNLG-------------------------------GSGTQERYRLEEP 595

Human   535 PPASAPVGGTVTLREDSAKRLERRARRISACLSDYSLASDSGVFEPLTKRNEDAEEPAYGDTASN 599
            .|...|:|...::    |.....:...:||.:||.|:|.||||:|...:|...:|..|:....|.
Mouse   596 GPEGKPLGQAASV----APGCGLKVACVSAAVSDESVAGDSGVYEASAQRPGTSEAAAFDSDESE 656

Human   600 --GDPQIHVGLLRDSGSECLLVHVLQLKNPAGLAVKEDCKVHIRVYLPPLDSGTPNTYCSKALEF 662
              |..::.:.|..|..::...:.::||.:.:.|::::|.||:|||.:.|....:...:.::.|:.
Mouse   657 AVGATRVQIALKYDEKNKQFAILIIQLSHLSALSLQQDQKVNIRVAILPCSESSTCLFRTRPLDS 721

Human   663 QVPLVFNEVFRIPVHSSALTLKSLQLYVCSVTPQLQEELLGIAQINLADYDSLSEMQLRWHSVQV 727
            ...|||||.|.:.:...||..|:|::.||:......||.||.|||:||:.....|...||:::..
Mouse   722 ANTLVFNEAFWVSISYPALHQKTLRVDVCTTDRSHTEECLGGAQISLAEVCRSGERSTRWYNLLS 786

Human   728 F-----TSSEPSRTREAGCAGESSARDPAHTISISGKTDAVTVLLARTTAQLQAVERELAEERAK 787
            :     ...||..|...|         |.|       .|||:.||.:|     |||.|..:|...
Mouse   787 YKYLKKQCREPQPTEAPG---------PDH-------VDAVSALLEQT-----AVELEKRQEGRS 830

Human   788 LEYTEEEVLEMERKEEQAEAISERSWQADSVDSGCSNCTQTSPPYPEPCCMGIDSILGHPFAAQA 852
            ...|.|.....|.:..:.||::|...:.:.     ...|:...|..|.|
Mouse   831 SSQTLEGSWTYEEEASENEAVAEEEEEGEE-----DVFTEKVSPEAEEC---------------- 874

Human   853 GPYSPEKFQPSPLKVDKETNTEDLFLEEAASLVKERPSRRARGS----PFVRSGTIVRSQTFSPG 913
                     |: ||||:||||:.:    |.|....||..|..|:    ||:|..||:||:|||||
Mouse   875 ---------PA-LKVDRETNTDSV----APSPTVVRPKDRRVGAPSTGPFLRGNTIIRSKTFSPG 925

Human   914 ARSQYVCRLYRSDSDSSTLPRKSPFVRNTLERRTLRYKQ--SCRSSLAELMARTSLDLELDLQAS 976
            .:|||||||.|||||||||.:|.|||||:||||::|.|:  |.:|...|.:.||||||||||||:
Mouse   926 PQSQYVCRLNRSDSDSSTLSKKPPFVRNSLERRSVRMKRPSSVKSLRTERLIRTSLDLELDLQAT 990

Human   977 RTRQRQLNEELCALRELRQRLEDAQLRGQTDLPPWVLRDERLRGLLREAERQTRQTKLDYRHEQA 1041
            ||...||.:|:..|:||::.||.|:..|:.:||.|:..|||.|.|||..|::.  .:.:::.|..
Mouse   991 RTWHSQLTQEISVLKELKEHLEQAKNHGEKELPQWLREDERFRLLLRMLEKKV--DRGEHKSELQ 1053

Human  1042 AEKMLKKASKEIYQLRGQSHKEPIQVQTFREKIAFFTRPRINIPPLPADDV 1092
            |:||::.|:|::::|||||.|||.:||:||||:|||||||:|||.|.||||
Mouse  1054 ADKMMRAAAKDVHRLRGQSCKEPPEVQSFREKMAFFTRPRMNIPALSADDV 1104

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
WWC3	NP_056506.2	THOC7	<4..119	CDD:283305	70/114 (61%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	363..384		17/21 (81%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	422..488		34/100 (34%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	510..544		8/37 (22%)
		C2_Kibra	602..725	CDD:176062	37/122 (30%)
Wwc1	NP_740749.1	WW	9..39	CDD:238122
		WW	55..84	CDD:278809	7/11 (64%)
		ALDH-SF	378..>420	CDD:299846	19/41 (46%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	429..449		13/19 (68%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	509..547		17/37 (46%)
		C2_Kibra	661..784	CDD:176062	37/122 (30%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	822..949		56/161 (35%)
		Interaction with histone H3. /evidence=ECO:0000250	836..1104		135/304 (44%)
		Interaction with PRKCZ. /evidence=ECO:0000250	945..988		24/42 (57%)
		ADDV motif	1102..1104		1/1 (100%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_COG5021
HGNC	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
NCBI	0	0.000	Not matched by this tool.
OMA	1	1.010	-	-		QHG50236
OrthoDB	1	1.010	-	-		D181722at33208
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	1	0.900	-	-		OOG6_103792
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	1	1.000	-	-		X1418
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	6	5.730