Protein Alignment PRKCI and Prkci

DIOPT Version :10

• Sequence 1: NP_002731.4
• Gene: PRKCI / 5584
• HGNCID: 9404
• Length: 596
• Species: Homo sapiens
• Sequence 2: NP_114448.1
• Gene: Prkci / 84006
• RGDID: 620961
• Length: 596
• Species: Rattus norvegicus
• Alignment Length: 596
• Identity: 588/596 - (98%)
• Similarity: 590/596 - (98%)
• Gaps: 0/596 - (0%)

Human     1 MPTQRDSSTMSHTVAGGGSGDHSHQVRVKAYYRGDIMITHFEPSISFEGLCNEVRDMCSFDNEQL 65
            |||||||||||||||.||.||||||||||||||||||||||||||||||||:||||||||||||.
  Rat     1 MPTQRDSSTMSHTVACGGGGDHSHQVRVKAYYRGDIMITHFEPSISFEGLCSEVRDMCSFDNEQP 65

Human    66 FTMKWIDEEGDPCTVSSQLELEEAFRLYELNKDSELLIHVFPCVPERPGMPCPGEDKSIYRRGAR 130
            |||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
  Rat    66 FTMKWIDEEGDPCTVSSQLELEEAFRLYELNKDSELLIHVFPCVPERPGMPCPGEDKSIYRRGAR 130

Human   131 RWRKLYCANGHTFQAKRFNRRAHCAICTDRIWGLGRQGYKCINCKLLVHKKCHKLVTIECGRHSL 195
            |||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
  Rat   131 RWRKLYCANGHTFQAKRFNRRAHCAICTDRIWGLGRQGYKCINCKLLVHKKCHKLVTIECGRHSL 195

Human   196 PQEPVMPMDQSSMHSDHAQTVIPYNPSSHESLDQVGEEKEAMNTRESGKASSSLGLQDFDLLRVI 260
            |.||:|||||||||.||.|||||||||||||||||||||||||||||||||||||||||||||||
  Rat   196 PPEPMMPMDQSSMHPDHTQTVIPYNPSSHESLDQVGEEKEAMNTRESGKASSSLGLQDFDLLRVI 260

Human   261 GRGSYAKVLLVRLKKTDRIYAMKVVKKELVNDDEDIDWVQTEKHVFEQASNHPFLVGLHSCFQTE 325
            |||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
  Rat   261 GRGSYAKVLLVRLKKTDRIYAMKVVKKELVNDDEDIDWVQTEKHVFEQASNHPFLVGLHSCFQTE 325

Human   326 SRLFFVIEYVNGGDLMFHMQRQRKLPEEHARFYSAEISLALNYLHERGIIYRDLKLDNVLLDSEG 390
            |||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
  Rat   326 SRLFFVIEYVNGGDLMFHMQRQRKLPEEHARFYSAEISLALNYLHERGIIYRDLKLDNVLLDSEG 390

Human   391 HIKLTDYGMCKEGLRPGDTTSTFCGTPNYIAPEILRGEDYGFSVDWWALGVLMFEMMAGRSPFDI 455
            |||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
  Rat   391 HIKLTDYGMCKEGLRPGDTTSTFCGTPNYIAPEILRGEDYGFSVDWWALGVLMFEMMAGRSPFDI 455

Human   456 VGSSDNPDQNTEDYLFQVILEKQIRIPRSLSVKAASVLKSFLNKDPKERLGCHPQTGFADIQGHP 520
            |||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
  Rat   456 VGSSDNPDQNTEDYLFQVILEKQIRIPRSLSVKAASVLKSFLNKDPKERLGCHPQTGFADIQGHP 520

Human   521 FFRNVDWDMMEQKQVVPPFKPNISGEFGLDNFDSQFTNEPVQLTPDDDDIVRKIDQSEFEGFEYI 585
            |||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
  Rat   521 FFRNVDWDMMEQKQVVPPFKPNISGEFGLDNFDSQFTNEPVQLTPDDDDIVRKIDQSEFEGFEYI 585

Human   586 NPLLMSAEECV 596
            |||||||||||
  Rat   586 NPLLMSAEECV 596

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
PRKCI	NP_002731.4	Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	1..23		19/21 (90%)
		Regulatory domain	2..253		242/250 (97%)
		Required for interaction with RAB2	2..28		23/25 (92%)
		PB1_aPKC	26..108	CDD:99725	79/81 (98%)
		Interaction with PARD6A	72..91		18/18 (100%)
		Pseudosubstrate. /evidence=ECO:0000250	125..134		8/8 (100%)
		C1_aPKC	139..193	CDD:410344	53/53 (100%)
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	220..246		25/25 (100%)
		STKc_aPKC_iota	233..596	CDD:270769	362/362 (100%)
Prkci	NP_114448.1	Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	1..21		17/19 (89%)
		Regulatory domain. /evidence=ECO:0000250	2..253		242/250 (97%)
		Required for interaction with RAB2. /evidence=ECO:0000250	2..28		23/25 (92%)
		PB1_aPKC	26..108	CDD:99725	79/81 (98%)
		Interaction with PARD6A. /evidence=ECO:0000250	72..91		18/18 (100%)
		Pseudosubstrate. /evidence=ECO:0000250	125..134		8/8 (100%)
		C1_aPKC	139..193	CDD:410344	53/53 (100%)
		STKc_aPKC_iota	233..596	CDD:270769	362/362 (100%)