Protein Alignment PRKCI and prkci

DIOPT Version :10

• Sequence 1: NP_002731.4
• Gene: PRKCI / 5584
• HGNCID: 9404
• Length: 596
• Species: Homo sapiens
• Sequence 2: NP_001012707.1
• Gene: prkci / 503517
• XenbaseID: XB-GENE-481945
• Length: 588
• Species: Xenopus tropicalis
• Alignment Length: 596
• Identity: 545/596 - (91%)
• Similarity: 571/596 - (95%)
• Gaps: 8/596 - (1%)

Human     1 MPTQRDSSTMSHTVAGGGSGDHSHQVRVKAYYRGDIMITHFEPSISFEGLCNEVRDMCSFDNEQL 65
            |||||| :|||.      ..|||||||||||::||||||||||||:|:||||||||||||:|:|.
 Frog     1 MPTQRD-NTMSQ------PSDHSHQVRVKAYFKGDIMITHFEPSITFDGLCNEVRDMCSFENDQP 58

Human    66 FTMKWIDEEGDPCTVSSQLELEEAFRLYELNKDSELLIHVFPCVPERPGMPCPGEDKSIYRRGAR 130
            |||||||||||||||||||||||||||||||||||||||||||:||||||||.||||||||||||
 Frog    59 FTMKWIDEEGDPCTVSSQLELEEAFRLYELNKDSELLIHVFPCIPERPGMPCAGEDKSIYRRGAR 123

Human   131 RWRKLYCANGHTFQAKRFNRRAHCAICTDRIWGLGRQGYKCINCKLLVHKKCHKLVTIECGRHSL 195
            ||||||||||||||||||||||||||||||||||||||||||||||||||||||||:||||||::
 Frog   124 RWRKLYCANGHTFQAKRFNRRAHCAICTDRIWGLGRQGYKCINCKLLVHKKCHKLVSIECGRHTI 188

Human   196 PQEPVMPMDQSSMHSDHAQTVIPYNPSSHESLDQVGEEKEAMNTRESGKASSSLGLQDFDLLRVI 260
             .|||:|||...|||||::..:||.|.|.::||||||||||||:|||||..||||||||||:|||
 Frog   189 -AEPVIPMDPPGMHSDHSEPXLPYRPRSQDNLDQVGEEKEAMNSRESGKTPSSLGLQDFDLMRVI 252

Human   261 GRGSYAKVLLVRLKKTDRIYAMKVVKKELVNDDEDIDWVQTEKHVFEQASNHPFLVGLHSCFQTE 325
            ||||||||||||||||:||||||||||||||||||||||||||||||||||||||||||||||||
 Frog   253 GRGSYAKVLLVRLKKTERIYAMKVVKKELVNDDEDIDWVQTEKHVFEQASNHPFLVGLHSCFQTE 317

Human   326 SRLFFVIEYVNGGDLMFHMQRQRKLPEEHARFYSAEISLALNYLHERGIIYRDLKLDNVLLDSEG 390
            |||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
 Frog   318 SRLFFVIEYVNGGDLMFHMQRQRKLPEEHARFYSAEISLALNYLHERGIIYRDLKLDNVLLDSEG 382

Human   391 HIKLTDYGMCKEGLRPGDTTSTFCGTPNYIAPEILRGEDYGFSVDWWALGVLMFEMMAGRSPFDI 455
            |||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
 Frog   383 HIKLTDYGMCKEGLRPGDTTSTFCGTPNYIAPEILRGEDYGFSVDWWALGVLMFEMMAGRSPFDI 447

Human   456 VGSSDNPDQNTEDYLFQVILEKQIRIPRSLSVKAASVLKSFLNKDPKERLGCHPQTGFADIQGHP 520
            |||||||||||||:|||||||||||||||||||||||||||||||||:||||||||||||||||.
 Frog   448 VGSSDNPDQNTEDFLFQVILEKQIRIPRSLSVKAASVLKSFLNKDPKDRLGCHPQTGFADIQGHQ 512

Human   521 FFRNVDWDMMEQKQVVPPFKPNISGEFGLDNFDSQFTNEPVQLTPDDDDIVRKIDQSEFEGFEYI 585
            ||||||||:||||||||||||||||||||||||:|||||||||||||:|:|||||||||||||||
 Frog   513 FFRNVDWDLMEQKQVVPPFKPNISGEFGLDNFDAQFTNEPVQLTPDDEDVVRKIDQSEFEGFEYI 577

Human   586 NPLLMSAEECV 596
            |||||||||||
 Frog   578 NPLLMSAEECV 588

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
PRKCI	NP_002731.4	Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	1..23		10/21 (48%)
		Regulatory domain	2..253		208/250 (83%)
		Required for interaction with RAB2	2..28		14/25 (56%)
		PB1_aPKC	26..108	CDD:99725	74/81 (91%)
		Interaction with PARD6A	72..91		18/18 (100%)
		Pseudosubstrate. /evidence=ECO:0000250	125..134		8/8 (100%)
		C1_aPKC	139..193	CDD:410344	52/53 (98%)
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	220..246		19/25 (76%)
		STKc_aPKC_iota	233..596	CDD:270769	350/362 (97%)
prkci	NP_001012707.1	PB1_aPKC	19..101	CDD:99725	74/81 (91%)
		C1_aPKC	132..186	CDD:410344	52/53 (98%)
		STKc_aPKC_iota	225..588	CDD:270769	350/362 (97%)