Protein Alignment PRKCI and ppk22

DIOPT Version :10

• Sequence 1: NP_002731.4
• Gene: PRKCI / 5584
• HGNCID: 9404
• Length: 596
• Species: Homo sapiens
• Sequence 2: NP_596726.1
• Gene: ppk22 / 2540803
• PomBaseID: SPBC1861.09
• Length: 526
• Species: Schizosaccharomyces pombe
• Alignment Length: 438
• Identity: 129/438 - (29%)
• Similarity: 213/438 - (48%)
• Gaps: 78/438 - (17%)

Human   183 HKLVTIECGRHSLPQEPVMPMDQSSMHSDHAQTVIPYNPSSH-ESLDQVGEEKEAMNTRESGKAS 246
            ||      |..:.|..|::.|  |::..  ||..|..||.:: ....:.|:...:.|:.:..:.
pombe    95 HK------GVEAPPPRPLINM--SNIRK--AQVKILKNPGNYIFGRTEYGKRTYSGNSTKISRV- 148

Human   247 SSLGLQDFDLLRVIGRGSYAKVLLVRLKKTDRIYAMKVVKKELVNDDEDIDWVQTEKHVFEQASN 311
             .:....|:.:|::|:|...||.|||.|...|::|||::.|..:.....::.|..|:.:..: |.
pombe   149 -EVTPHSFEKIRLLGQGDVGKVYLVRQKSNHRLFAMKILNKREMIKRHKVNRVLAEQEILTK-SK 211

Human   312 HPFLVGLHSCFQTESRLFFVIEYVNGGDLM--FHMQRQRKLPEEHARFYSAEISLALNYLHERGI 374
            |||:|.|:..||:...|:..:||..||:..  .|...:..|||:.|.||:||::.||.|||..|.
pombe   212 HPFIVTLYHSFQSRDYLYLCMEYCAGGEFFRALHSLPKHILPEKDACFYAAEVTAALEYLHLMGF 276

Human   375 IYRDLKLDNVLLDSEGHIKLTDYGMCK------------------EGLRPG-DT--------TST 412
            ||||||.:|:||...|||.|:|:.:.|                  ...:|. ||        |::
pombe   277 IYRDLKPENILLHQSGHIMLSDFDLSKPISIVTHPTVVLPKHSTFSQEKPALDTNSYFSNFRTNS 341

Human   413 FCGTPNYIAPEILRGEDYGFSVDWWALGVLMFEMMAGRSPFDIVGSSDNPDQNTEDYLFQVILEK 477
            |.||..|||||::|...:..:||||.||:.::|::.|.:||.  |.:.:.       .|..||..
pombe   342 FVGTEEYIAPEVIRSCGHTVAVDWWTLGIFIYEILYGTTPFK--GKNRHA-------TFSNILYS 397

Human   478 QIRIPR-----SLSVKAASVLKSFLNKDPKERLGCHPQTGFADIQGHPFFRNVDWDMMEQKQVVP 537
            .:..|.     ::|....|:::..|.||..:|  |....|.:||:.|||||::.|.::  :.:.|
pombe   398 DVSFPEYHGAPNVSSTCKSLIRRLLVKDESKR--CGSVAGASDIKQHPFFRHIQWALL--RSMKP 458

Human   538 PFKPNISGEFGLDNFDSQFTNEPVQLTPDDDDIVRKIDQSEFEGFEYI 585
            |..|.|  |.|::           .:.|.|:|    .::.:|...:|:
pombe   459 PIIPKI--EDGME-----------AVEPSDND----NEEEDFLNSQYL 489

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
PRKCI	NP_002731.4	Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	1..23
		Regulatory domain	2..253		14/70 (20%)
		Required for interaction with RAB2	2..28
		PB1_aPKC	26..108	CDD:99725
		Interaction with PARD6A	72..91
		Pseudosubstrate. /evidence=ECO:0000250	125..134
		C1_aPKC	139..193	CDD:410344	3/9 (33%)
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	220..246		4/26 (15%)
		STKc_aPKC_iota	233..596	CDD:270769	116/387 (30%)
ppk22	NP_596726.1	STKc_phototropin_like	153..469	CDD:270726	110/331 (33%)