Protein Alignment PRKCI and pck2

DIOPT Version :10

• Sequence 1: NP_002731.4
• Gene: PRKCI / 5584
• HGNCID: 9404
• Length: 596
• Species: Homo sapiens
• Sequence 2: NP_595950.1
• Gene: pck2 / 2539649
• PomBaseID: SPBC12D12.04C
• Length: 1016
• Species: Schizosaccharomyces pombe
• Alignment Length: 634
• Identity: 199/634 - (31%)
• Similarity: 292/634 - (46%)
• Gaps: 184/634 - (29%)

Human   121 DKSIYRRGARRWRK--LYCANGHTFQAKRFNRRAHCAICTDRIWGLGRQGYKCINCKLLVHKKCH 183
            |..:.|:||.|.||  ::...||.|...:|.:...||:|.:.:  ....|.:||:|....||||:
pombe   384 DAGLGRQGAIRQRKESVHEVYGHKFLQHQFYQIMRCALCGEFL--KNAAGMQCIDCHYTCHKKCY 446

Human   184 -KLVT-----------------------------------------------------IECG--- 191
             |:||                                                     .|||
pombe   447 PKVVTKCISKSSDSASSEYEKINHRIPHHFESHTNIGANWCCHCGYILPLGRKTARKCTECGITA 511

Human   192 ----RHSLPQEPVMPMD----------------------QSSMHSDHAQTVIPYNPSSHESLD-- 228
                .|.:|....|.|:                      :||.|..|.......:.|.|:..|
pombe   512 HAQCVHLVPDFCGMSMEMANRVISEIRTTKIYKAQQHKQKSSHHKHHHHKKSKSSSSKHKENDKA 576

Human   229 ------------------------------------------------------QVGEEK----- 234
                                                                  ||.|:|
pombe   577 SVSITTTTTPSITPADPVPTSPKPLAIEPVKRKPVHAGNLEVTSVSDNKLGATVQVVEQKVDDKA 641

Human   235 EAMNTRESGKA----------------------SSSLGLQDFDLLRVIGRGSYAKVLLVRLKKTD 277
            :|:....|..|                      :..:||:||..|.|:|:|::.||:|..||...
pombe   642 DALTKPPSLDAVKEPIPVPSVETSVVAQDLTHKAKRIGLEDFTFLSVLGKGNFGKVMLAELKSEK 706

Human   278 RIYAMKVVKKELVNDDEDIDWVQTEKHVFEQAS--NHPFLVGLHSCFQTESRLFFVIEYVNGGDL 340
            ::||:||:|||.:.::::::..::||.||..|:  .|||||.||||||||:|::||:::|:||||
pombe   707 QLYAIKVLKKEFILENDEVESTKSEKRVFLVANRERHPFLVNLHSCFQTETRIYFVMDFVSGGDL 771

Human   341 MFHMQRQRKLPEEHARFYSAEISLALNYLHERGIIYRDLKLDNVLLDSEGHIKLTDYGMCKEGLR 405
            |.|:| |.:.....|:||:||:.|||.|.|:.|||||||||||:||..:||:|:.|||:|||.:.
pombe   772 MLHIQ-QEQFSRRRAQFYAAEVCLALKYFHDNGIIYRDLKLDNILLSPDGHVKVADYGLCKEDMW 835

Human   406 PGDTTSTFCGTPNYIAPEILRGEDYGFSVDWWALGVLMFEMMAGRSPFDIVGSSDNPDQNTEDYL 470
            ..:||:||||||.::|||||..:.|..||||||.|||:::|:.|:|||         ....|:.:
pombe   836 HDNTTATFCGTPEFMAPEILLEQQYTRSVDWWAFGVLIYQMLLGQSPF---------RGEDEEEI 891

Human   471 FQVILEKQIRIPRSLSVKAASVLKSFLNKDPKERLGCHPQTGFADIQGHPFFRNVDWDMMEQKQV 535
            |..||..:...|..:...:.|:|:..|.:|||:|||..|... .|:..||||.|::||.:..|:.
pombe   892 FDAILSDEPLYPIHMPRDSVSILQQLLTRDPKKRLGSGPNDA-EDVMTHPFFSNINWDDIYHKRT 955

Human   536 VPPFKPNISGEFGLDNFDSQFTNEPVQLTPDDDDIVRKIDQSEFEGFEY 584
            .||:.|:::.......||.:||.|...||| .:.|:.|..|..||||.|
pombe   956 QPPYIPSLNSPTDTKYFDEEFTRELPVLTP-VNSILTKEMQQHFEGFSY 1003

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
PRKCI	NP_002731.4	Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	1..23
		Regulatory domain	2..253		48/299 (16%)
		Required for interaction with RAB2	2..28
		PB1_aPKC	26..108	CDD:99725
		Interaction with PARD6A	72..91
		Pseudosubstrate. /evidence=ECO:0000250	125..134		4/8 (50%)
		C1_aPKC	139..193	CDD:410344	21/114 (18%)
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	220..246		10/108 (9%)
		STKc_aPKC_iota	233..596	CDD:270769	157/381 (41%)
pck2	NP_595950.1	HR1_PKC-like_1_fungi	2..73	CDD:212011
		HR1_PKC-like_2_fungi	115..186	CDD:212010
		C2_fungal_Pkc1p	213..320	CDD:176071
		C1_ScPKC1-like_rpt1	404..454	CDD:410372	18/51 (35%)
		C1_ScPKC1-like_rpt2	470..528	CDD:410373	6/57 (11%)
		STKc_PKC	688..1003	CDD:270722	147/326 (45%)