Protein Alignment CPAP and HDA3

DIOPT Version :10

• Sequence 1: NP_060921.3
• Gene: CPAP / 55835
• HGNCID: 17272
• Length: 1338
• Species: Homo sapiens
• Sequence 2: NP_015505.1
• Gene: HDA3 / 856309
• SGDID: S000006383
• Length: 655
• Species: Saccharomyces cerevisiae
• Alignment Length: 765
• Identity: 153/765 - (20%)
• Similarity: 250/765 - (32%)
• Gaps: 253/765 - (33%)

Human   423 KTALKNKELCADNPILKKDSKARTKSGSVTLSQKPKMLKCSNRKSLSPSGLKIQTGKKCDGQFRD 487
            ||...|..|.|.:|.|..|            ...||.|...:    .|:.|...:||  ....||
Yeast    75 KTMCLNGSLVATHPYLLID------------HYMPKSLITRD----VPAHLAENSGK--FSVLRD 121

Human   488 QIKFENKVTSNNKENVTECPKPCDTGCTGWNKTQGKDRLPLSTGPASRLAAKSPIR----ETMKE 548
            .|   |.|    :|..||....|..|.|       .|.|     .|..|..|..|:    .::|.
Yeast   122 LI---NLV----QEYETETAIVCRPGRT-------MDLL-----EALLLGNKVHIKRYDGHSIKS 167

Human   549 SESSLDVSLQKKLETWE-----REKEKENLELDEFLFLEQAADEISFSSNSSFVLKILERDQQIC 608
            .:.:.|.|....|.:.|     :...|.....|..:.|:...|  :...:..::|: .:|::
Yeast   168 KQKANDFSCTVHLFSSEGINFTKYPIKSKARFDMLICLDTTVD--TSQKDIQYLLQ-YKRER--- 226

Human   609 KGHRMSSTPVKAVPQKTNPADPISHCNR--SEDLDHTAREKESECEVAPKQLHSLSSA-----DE 666
            ||....:..|:.|     ..:.|.||..  .:..|..:||          .|.::::|     |.
Yeast   227 KGLERYAPIVRLV-----AINSIDHCRLFFGKKFDKNSRE----------YLENVTAAMVILRDR 276

Human   667 LREQPCKIRKAVQKSTSENQTEWNARDDEGVPNSD-------SSTDSEEQL--DVTIKPSTE--- 719
            |...|..:| .:.........||........|..|       :|.|.|..|  :|..|.|.:
Yeast   277 LGTLPPDLR-PIYSQKLHYLVEWLENPTVPWPLPDIYPLKQYTSMDVERSLLTEVHFKKSDDQLE 340

Human   720 ------DRERG-----------ISSRED--SPQVCDDK--------GPFKDTRTQEDKRRDVDLD 757
                  .::||           ::..||  :|.....|        .|.|...||.......| :
Yeast   341 DAFSNCSKKRGRHGANKAASSTVAGIEDNITPSFYSTKRLKNDYYTNPLKQDMTQLTGITTAD-N 404

Human   758 LSDKDYSSDESIMESIKHKVSEPSRS--SSLSLSKMDFDDERTWTDLEENLCNHDVVLGNESTYG 820
            .|:.:|.....|   |.||:.:....  ..:.:.|.:.||.....||:.   :|.....||
Yeast   405 SSNVNYHLSSGI---ITHKLIQSMGEVYMDICVQKQELDDYSCLDDLQN---DHLKFFSNE---- 459

Human   821 TPQTCYPNNEIGILDKTIKRKIAPVKR--GEDLSKSRRSRSPPTSELMMKFFPSLKPKPKSDSHL 883
                          |:.|.::...|.|  .|:|::|.        ||.::
Yeast   460 --------------DEKIIKEYETVLRTNNENLNRSH--------ELEVE--------------- 487

Human   884 GNELKLNISQDQPPGDNARSQVLREKIIELETEIEKFK----AENASLAKLR---IERESALEKL 941
             |.||.:                  :|..||.:||..|    |:..:|:||:   ::.::..:::
Yeast   488 -NNLKFS------------------QIETLEKDIETLKGSLMAQGETLSKLKDAFVKTDNVQDEI 533

Human   942 RKEIADFEQQKAKELARIEEFKKEEMRKLQKERKVFEKYTTAARTFPDKKEREEIQTLKQQIADL 1006
            .||            .|:...:..|.:.:::|.|   :...|.|     :..||...|.::...|
Yeast   534 EKE------------ERVSVSRDTEKKYMEQEIK---RAVDAIR-----ENEEETHKLNEKQNGL 578

Human  1007 REDLKRKETKWSSTHSRLRSQIQMLVRE---NTDLREEIKVMERFRLDAWKRAEAIESSLEVEKK 1068
            ..:||.|..|...:...|..:|..|.:|   ..||.||:               ..:.|..::..
Yeast   579 ESELKLKFEKSEISTKELNEKIGFLKKELKLENDLNEEL---------------VGQLSKTMDNL 628

Human  1069 DKLANTSVRFQNSQISSGTQVEKYKKNYLPMQGNPPRRSKSAPPRDLGNL 1118
            :.|....||.||                    ||..::|::..|   ||:
Yeast   629 ENLTIPRVRTQN--------------------GNTKKKSRAKKP---GNV 655

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
CPAP	NP_060921.3	Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	190..211
		Alpha/beta-tubulin binding. /evidence=ECO:0000269|PubMed:19131341	319..394
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	386..414
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	436..479		8/42 (19%)
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	521..551		7/33 (21%)
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	611..789		42/225 (19%)
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	845..865		5/21 (24%)
		SMC_N	<886..1148	CDD:481474	48/243 (20%)
		Interaction with STIL. /evidence=ECO:0000269|PubMed:22020124, ECO:0000269|PubMed:25385835	895..1338		46/234 (20%)
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	1096..1153		6/23 (26%)
		Tcp10_C	1152..1180	CDD:462118
		Tcp10_C	1225..1253	CDD:462118
		Tcp10_C	1261..1289	CDD:462118
		Tcp10_C	1296..1325	CDD:462118
HDA3	NP_015505.1	HDA2-3	26..299	CDD:402894	60/282 (21%)
		SMC_prok_B	<466..600	CDD:274008	37/195 (19%)