Protein Alignment CPAP and END3

DIOPT Version :10

• Sequence 1: NP_060921.3
• Gene: CPAP / 55835
• HGNCID: 17272
• Length: 1338
• Species: Homo sapiens
• Sequence 2: NP_014315.1
• Gene: END3 / 855640
• SGDID: S000005028
• Length: 349
• Species: Saccharomyces cerevisiae
• Alignment Length: 372
• Identity: 74/372 - (19%)
• Similarity: 145/372 - (38%)
• Gaps: 87/372 - (23%)

Human   676 KAVQKSTSENQT---EWNARDDEGVPNSD---SSTDSEEQLD-----VTIKPSTEDRERGISSRE 729
            |.::...:.:|.   .:|::.|..|.|..   :..|.::.||     :.::...:...:.|||..
Yeast    20 KPIENKVNHDQVLPILYNSKLDSSVLNKIWFLADIDDDDNLDFEEFVICMRLIFDMVNKNISSVP 84

Human   730 DSPQVCDDKGP-FKDTRTQEDKRR--------------DVDLDLSDKDYSSDESIMESIK----- 774
            |  ::.|...| .|....:|.|:|              .||..:|..|.:..|.|..|..
Yeast    85 D--ELPDWLIPGSKVNLIKERKKRKQIENADLPPKKEIKVDWYMSPDDLNQYEKIYNSCAKLTDG 147

Human   775 ----HKVSEPSRSSSLSLSKMDFDDERTWTDLE-ENLCNHDVVLGNESTYGTPQTCYPNNEIGI- 833
                :::|....:...::||.|.:  :.|:.:. :||.:.|    .:.|:.........|::|.
Yeast   148 TITFNELSTKLSTKFFNISKTDLN--KVWSLINPQNLPSID----RDPTFYFIHCLRQRNDLGAE 206

Human   834 LDKTIKRKIAPVKRGEDLSKSRRSRSPPTSELMMKFFPSLKPKPKSDSHLGNELKLNISQDQPPG 898
            :..::...:|.|...:.||...||..|||             |.|.:::..:.|:.|       |
Yeast   207 IPASLPNSLAEVCNKKQLSYDLRSSQPPT-------------KRKEEANEVDNLRDN-------G 251

Human   899 DNARSQVLREKIIELETEIEKFKAENASL-----AKLRIERESALEKLRKEIADFEQQKAKELAR 958
            .|:.|......::..|..|   |.:.|||     |.:|.:.|..|...:.|    :.|...:|::
Yeast   252 QNSSSDSSGSNVLSNEDSI---KQKYASLTDDQVANMREQLEGLLNYKKSE----KTQGGSKLSK 309

Human   959 IEEFKK--EEMRKLQKERKVFEKYTTAARTFPDKKEREEIQTLKQQI 1003
            ....:.  :::..::::.:|.|.|.        ..:|.|:|.|:.:|
Yeast   310 RINIRSITDDLDNIEQQVEVLENYL--------NNKRHELQALQAEI 348

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
CPAP	NP_060921.3	Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	190..211
		Alpha/beta-tubulin binding. /evidence=ECO:0000269|PubMed:19131341	319..394
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	386..414
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	436..479
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	521..551
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	611..789		27/147 (18%)
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	845..865		8/19 (42%)
		SMC_N	<886..1148	CDD:481474	26/125 (21%)
		Interaction with STIL. /evidence=ECO:0000269|PubMed:22020124, ECO:0000269|PubMed:25385835	895..1338		24/116 (21%)
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	1096..1153
		Tcp10_C	1152..1180	CDD:462118
		Tcp10_C	1225..1253	CDD:462118
		Tcp10_C	1261..1289	CDD:462118
		Tcp10_C	1296..1325	CDD:462118
END3	NP_014315.1	EF-hand_4	1..104	CDD:289529	17/85 (20%)
		EH	123..221	CDD:197477	19/103 (18%)
		End3	186..345	CDD:432765	39/197 (20%)