Protein Alignment CPAP and PAN1

DIOPT Version :10

• Sequence 1: NP_060921.3
• Gene: CPAP / 55835
• HGNCID: 17272
• Length: 1338
• Species: Homo sapiens
• Sequence 2: NP_012271.3
• Gene: PAN1 / 854822
• SGDID: S000001445
• Length: 1480
• Species: Saccharomyces cerevisiae
• Alignment Length: 913
• Identity: 178/913 - (19%)
• Similarity: 324/913 - (35%)
• Gaps: 267/913 - (29%)

Human   117 HQEENKNDFIPDLASEFKEGAYKDPLFKKLEQLKEVQQK------------KQEQLKRQQLEQLQ 169
            :.:.|.|:.:.|.:|:.|....:..||.|:.:..:.|.|            ::..|.|..|||:.
Yeast   578 YTKSNFNNNLIDNSSQDKISTEEKSLFYKIFETFDTQNKGLLDSPTAVEIFRKSGLNRADLEQIW 642

Human   170 RL--------MEEQEKLLTM--VSGQCT---LPGL---SLLPDD-------QSQKHRSPGNTTTG 211
            .|        :.:||..|.|  |.|:..   :|.:   ||:|..       ::|....|  |||.
Yeast   643 NLCDINNTGQLNKQEFALGMHLVYGKLNGKPIPNVLPSSLIPSSTKLLDNLKNQLKTEP--TTTK 705

Human   212 ERATCCFPSYVYPDPTQEETYPSNILSHEQSNFCRTAHGDFVLTSKRASPNLFSEAQYQEAPVEK 276
            |:     ||:...|          .||::.::       |.||.:.|....::|....:::....
Yeast   706 EK-----PSFGKID----------ALSYKNND-------DDVLPNYRNRRKVYSAKNEEQSSFSS 748

Human   277 NNLKEENRNHPTGES-ILCWEKVTEQ----------IQEANDKNLQKHD-------------DSS 317
            .:.|..|.:..|.:: .:..:|..|:          .:|.|.||:...:             |||
Yeast   749 PSAKSVNHSSSTLQTDDISVDKTVEKKTAKPKYAGFSREINLKNIASLENEIKNISNPENCYDSS 813

Human   318 EVANIEERPIKAAIGERKQTFEDY--LEEQIQLEEQELKQKQLKEAEGPLPIKAKPKQPFLKRGE 380
            ..:::..| ..|.|.:....|.:.  ::.:|...:.:|.:|               |.|....|.
Yeast   814 IPSDLTSR-FDAIIAKLPNLFNEISTIDNEITNAKIQLYRK---------------KNPSSIIGS 862

Human   381 G-LARFT-----NAKSKFQKGKESKLVTNQSTSEDQPLFKMDRQQ------LQRKTALKNKELCA 433
            | ....|     .|||:.........:|.:||..:..|...|.||      :|::.. ||:|:..
Yeast   863 GPNGEITENDRKKAKSRALLRARMSALTGKSTESEDSLSMEDEQQSAEIKRIQQENG-KNQEIIK 926

Human   434 DNPILKKDSKARTKSGSVTLSQKPKML---KCSNRK-SLSPSGLKIQTGKKCDGQFRDQIKFENK 494
            |         .|:....::.|.|..|.   ..||:: .....|:.::.|.:   :|.|.:|
Yeast   927 D---------IRSSISDISASLKSTMTGSNMISNQEFERWEFGIGLEDGVR---EFLDDLK---- 975

Human   495 VTSNNKENVTE--------CPKPCDTGCTGWNKTQGKDRLPLSTGPASRLAA--KSPIRETMKE- 548
              ||:.::|||        .|.|.|...:..:.:|.|        .|...||  |...::.|||
Yeast   976 --SNSNKSVTESSPFVPSSTPTPVDDRSSSPSYSQFK--------TAEERAAYLKEQAKKRMKEK 1030

Human   549 -----------SESSLDVSLQKKLETWEREKEKENL-ELDEFLFLEQAADEISFSSNSSFVLKIL 601
                       ::||..:|.:...|..::.....|| |.....|.|:...|::..:......:.:
Yeast  1031 LAKFDKNRRNVTQSSRSISSENSREQPQQIAGSSNLVEPRATPFQEEKYVEVAQPTQPVQSTQPV 1095

Human   602 ERDQQICKGHRMSSTPVKAVPQKTNPADPISHC----NRSEDLDHTAREKESECEVAPKQLHSLS 662
            :..|.:.....:..|......|...|..|:.:.    ..|:|.|....||..:.|:  |:|....
Yeast  1096 QPTQPVQPTQPVQPTQPVQPTQPVQPTQPVQNVYNAKQESDDEDEDDEEKRLQEEL--KRLKLKK 1158

Human   663 SADELREQPCKIRKAVQKSTSE-NQTEWNARDDEG----VPN----------SDSSTDSEEQLDV 712
            .||: .::...:||.::.:.:| ::.|.|.:|:.|    ||.          |.:||::...:..
Yeast  1159 KADK-EKRLAALRKQIEDAQNESDEEETNGKDNFGGHVNVPQAAPVAPSAAFSQNSTNAPRSVHA 1222

Human   713 TIKPSTEDRERGISSREDSPQVCDDKGP-FKDTRTQEDKRRDVDLDLSDKDYSSDESIMESIKHK 776
            .:.|:......|:      |.......| |||.........|.                     :
Yeast  1223 AVTPAAGKNSTGL------PSTTMGHNPYFKDASASSTSTFDA---------------------R 1260

Human   777 VSEPSRSSSLSLSKMDFDDERTWTDLEENLCNHDVVLGNESTYGTPQTCYPNNEIGILDKTIKRK 841
            .:|..|.....|   |.|::..|:|.:|:                      ||.:.:.:|..:.|
Yeast  1261 AAEMQRRIQRGL---DEDEDDGWSDEDES----------------------NNRVAVDNKVEEAK 1300

Human   842 IAPVKRGEDLSKSRRSRSPPTSELMMKFFPSLKPKPKS----DSHLGNE---------LKLNISQ 893
            |         .....:|:||.:...:   ||:.|.|.:    .::..||         :..:::|
Yeast  1301 I---------GHPDHARAPPVTAAPL---PSVTPVPPAVPVPQANTSNEKSSPIPIAPIPPSVTQ 1353

Human   894 DQP 896
            :.|
Yeast  1354 EPP 1356

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
CPAP	NP_060921.3	Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	190..211		7/30 (23%)
		Alpha/beta-tubulin binding. /evidence=ECO:0000269|PubMed:19131341	319..394		15/82 (18%)
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	386..414		8/32 (25%)
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	436..479		7/46 (15%)
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	521..551		9/43 (21%)
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	611..789		36/197 (18%)
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	845..865		3/19 (16%)
		SMC_N	<886..1148	CDD:481474	3/20 (15%)
		Interaction with STIL. /evidence=ECO:0000269|PubMed:22020124, ECO:0000269|PubMed:25385835	895..1338		1/2 (50%)
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	1096..1153
		Tcp10_C	1152..1180	CDD:462118
		Tcp10_C	1225..1253	CDD:462118
		Tcp10_C	1261..1289	CDD:462118
		Tcp10_C	1296..1325	CDD:462118
PAN1	NP_012271.3	DUF1720	144..243	CDD:369766
		EH	265..356	CDD:197477
		DUF1720	<391..453	CDD:369766
		DUF1720	459..553	CDD:369766
		EH	595..688	CDD:197477	22/92 (24%)
		MAT1	<833..>934	CDD:461894	25/125 (20%)
		PAT1	982..>1127	CDD:401645	30/152 (20%)
		Amelogenin	<1064..1125	CDD:197891	10/60 (17%)