Protein Alignment CPAP and IRS4

DIOPT Version :10

• Sequence 1: NP_060921.3
• Gene: CPAP / 55835
• HGNCID: 17272
• Length: 1338
• Species: Homo sapiens
• Sequence 2: NP_012944.3
• Gene: IRS4 / 853889
• SGDID: S000001727
• Length: 615
• Species: Saccharomyces cerevisiae
• Alignment Length: 443
• Identity: 99/443 - (22%)
• Similarity: 175/443 - (39%)
• Gaps: 90/443 - (20%)

Human   403 NQSTSEDQP-LFKMDRQQLQRKTALKNKEL-----CADNPI----------LKKDSKARTKSGSV 451
            |..|...:| |.|..|:|.|:|..::.|::     .|.|.:          ..||:.:.|...:.
Yeast    53 NPQTRLSEPSLQKSGRKQEQKKARIRTKQVPKIKTTAPNDVELSKKHRSSPAGKDNVSSTAQMAA 117

Human   452 TLSQKPKMLKCSNRKSLSPS--GLKIQTGKKCDGQFRDQIKFENKVTSNNKENVTECPKPCDTGC 514
            .|:.....|...|..|.|.:  .||:......:|......:..::..||  |::|...:..|
Yeast   118 ALAHSQSKLSSDNNSSHSSALDTLKVLETPNLNGLLGIHSRSSSRNGSN--ESLTPGQRTPD--- 177

Human   515 TGWNKTQGKDRLPLSTGPASRLAAKSPIRETMKESESSL-----DVSLQKKLETWEREKEKENL- 573
               |::|  :.|..|.....||::.|....|.|:|..:|     ...||..|....:..|.|||
Yeast   178 ---NRSQ--ENLLTSFSSGRRLSSSSMEPATNKDSNKALPKRRPSPPLQSSLVGSGQLHENENLS 237

Human   574 --ELDEFLFLE-QAADEISFSSNSSF-----VLKILERDQQICKGHRMSSTPVKAVPQKTNPADP 630
              .:|....|. ..:|.||..|.:|.     .|.:.|.:..|...:..::|        :|....
Yeast   238 SISIDSRHSLNPDTSDVISNRSQTSLSQTINQLSLCESEPSIASSNTTTTT--------SNQGSG 294

Human   631 ISHC--NRSEDLDHTAREKESECEV---APKQLHSL----SSADEL---REQP-----CKIRKAV 678
            :.:.  |.|.|:.......:.:.:|   .||.|.|.    :|::||   .:||     ..:||..
Yeast   295 LPNLVPNYSSDMRKKKLVNKFKRKVFGSKPKHLSSQYEMDASSEELGQHEQQPSMRFKTTLRKTS 359

Human   679 QKSTSEN-----------QTEWNARDD--EGVPNSDSSTDSEEQLDVTIKPSTEDR-ERGISSRE 729
            ..:.:||           :.::|..:|  :...::||.::|::..|...||...|| :|.|  |.
Yeast   360 VSTNAENDHASSLHEGNLRYKYNPSNDTYDVYDDTDSDSESDQNQDALTKPRKRDRIKRKI--RN 422

Human   730 DSPQVCDDKGPF---KDTRTQEDK--RRDVDLD-LSDKDYSSDESIMESIKHK 776
            .:.:....: |.   :|.:..|||  :...|:. ::|.:....||:..|.:|:
Yeast   423 SANKTAHHR-PIHRTRDRKFNEDKPWKSHTDITFVTDNERKRYESMWVSNRHR 474

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
CPAP	NP_060921.3	Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	190..211
		Alpha/beta-tubulin binding. /evidence=ECO:0000269|PubMed:19131341	319..394
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	386..414		4/11 (36%)
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	436..479		10/54 (19%)
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	521..551		9/29 (31%)
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	611..789		43/203 (21%)
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	845..865
		SMC_N	<886..1148	CDD:481474
		Interaction with STIL. /evidence=ECO:0000269|PubMed:22020124, ECO:0000269|PubMed:25385835	895..1338
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	1096..1153
		Tcp10_C	1152..1180	CDD:462118
		Tcp10_C	1225..1253	CDD:462118
		Tcp10_C	1261..1289	CDD:462118
		Tcp10_C	1296..1325	CDD:462118
IRS4	NP_012944.3	EH	<498..570	CDD:197477