Protein Alignment CPAP and TAX4

DIOPT Version :10

• Sequence 1: NP_060921.3
• Gene: CPAP / 55835
• HGNCID: 17272
• Length: 1338
• Species: Homo sapiens
• Sequence 2: NP_012452.1
• Gene: TAX4 / 853362
• SGDID: S000003619
• Length: 604
• Species: Saccharomyces cerevisiae
• Alignment Length: 378
• Identity: 82/378 - (21%)
• Similarity: 132/378 - (34%)
• Gaps: 106/378 - (28%)

Human   778 SEPSRSSSLSLSKMDFDDERTWTDLEENLCNH----DVVLGNESTYGTPQTCYPNNEIGILDKTI 838
            |.|...|..||.:|...:.|:        .||    :.:.|:...:..|.|........:.:|..
Yeast    56 SAPVVKSEPSLPRMRQPEPRS--------INHQYSRETLPGHSEAFSVPTTPLQTIHYDVRNKAS 112

Human   839 K--RKIAPVKRGEDL----SKSRRSRSPPTSELMMKFFPSLKPKPKSDSHLGNELKLNISQDQPP 897
            .  ..||..:....|    |.|.||....:.:.:|.  ...|| |::.|.|.|||:||..:..||
Yeast   113 NSPSSIAAAETAAYLAHTNSFSNRSSGVGSRDPVMD--TETKP-PRAPSALKNELQLNRMRIPPP 174

Human   898 G--DNARSQVLREKIIELETEIEKFKAENASLAKLRIERESALEKLRKEIADFEQQKAKELARIE 960
            .  :|.||:.:..: :...|.:    :.:.|::                 :|.|:...:|.:..|
Yeast   175 SYDNNVRSRSISPQ-VSYSTSL----SSSCSIS-----------------SDGEETSYREKSTDE 217

Human   961 EFKKE-EMRKLQKERKVFEKYTTAARTFPDKKEREEIQT-----------LKQQIADLREDLKRK 1013
            .|..| .|.......|...|   |:.|.|.::::|...|           .|..:.||....:||
Yeast   218 AFPPEPSMSSYSLASKASAK---ASLTDPSQRQQESDYTAMNKLNGGNIIYKGTLPDLIPRSQRK 279

Human  1014 ETKWSSTHSRLRSQIQMLVRENTDLREEIKVMERFRLDAWKRAEAIESSLEVEKKDKLANTSVR- 1077
            .:|....|..|||..|.  :||         :.|...|..:...||   :..::..||..|..|
Yeast   280 TSKPRFKHRLLRSPEQQ--QEN---------LSRVYSDQTQNGRAI---INTQQNVKLKTTMRRG 330

Human  1078 ------------FQNSQISSGTQV----------EKYKKNYLPMQGNPPRRSK 1108
                        :....:||.:..          :|.||:         ||||
Yeast   331 KYAITDNDETFPYDRKSVSSDSDTDEDSNVMEIKDKKKKS---------RRSK 374

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
CPAP	NP_060921.3	Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	190..211
		Alpha/beta-tubulin binding. /evidence=ECO:0000269|PubMed:19131341	319..394
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	386..414
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	436..479
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	521..551
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	611..789		4/10 (40%)
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	845..865		5/23 (22%)
		SMC_N	<886..1148	CDD:481474	55/260 (21%)
		Interaction with STIL. /evidence=ECO:0000269|PubMed:22020124, ECO:0000269|PubMed:25385835	895..1338		51/251 (20%)
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	1096..1153		4/13 (31%)
		Tcp10_C	1152..1180	CDD:462118
		Tcp10_C	1225..1253	CDD:462118
		Tcp10_C	1261..1289	CDD:462118
		Tcp10_C	1296..1325	CDD:462118
TAX4	NP_012452.1	EH	463..557	CDD:197477