Protein Alignment CPAP and EDE1

DIOPT Version :10

• Sequence 1: NP_060921.3
• Gene: CPAP / 55835
• HGNCID: 17272
• Length: 1338
• Species: Homo sapiens
• Sequence 2: NP_009506.1
• Gene: EDE1 / 852233
• SGDID: S000000143
• Length: 1381
• Species: Saccharomyces cerevisiae
• Alignment Length: 1086
• Identity: 204/1086 - (18%)
• Similarity: 380/1086 - (34%)
• Gaps: 322/1086 - (29%)

Human   232 YPSNILSHEQSNFCRTAHGDFVLTSKRASPNLFSEAQYQEAPVEKN-----NLKEENRNHPTGES 291
            ||.|.|..:||      .....:.|:.:.|:|........||....     .:..:|.|:.:...
Yeast   368 YPPNPLPQQQS------APQIAIPSRASKPSLQDMPHQVSAPAVNTQPTVPQVLPQNSNNGSLND 426

Human   292 ILCWE--------KVTEQIQEANDKNLQKHDDSSEVANIEER------PI-KAAIGERKQTFEDY 341
            :|...        ...:.:.:.|..|...:|:::..|.::::      |: .::.|.:|.|....
Yeast   427 LLALNPSFSSPSPTKAQTVVQNNTNNSFSYDNNNGQATLQQQQPQQPPPLTHSSSGLKKFTPTSN 491

Human   342 LEEQIQLEEQELKQKQLKEAEG-----PLPIKAKPKQPFLKR--GEGLARFTN-AKSKFQKGKES 398
            ..:.|..||.| :|:||:|:..     |.|:......| :||  ...|.:..| :......|..:
Yeast   492 FGQSIIKEEPE-EQEQLRESSDTFSAQPPPVPKHASSP-VKRTASTTLPQVPNFSVFSMPAGAAT 554

Human   399 KLVTNQSTSEDQPLFKMDRQQLQRKT--ALKNKELCADNPILKKDSKARTKSGSV-----TLSQK 456
            ...|..:.........:......|.:  |.||::|.||.....:.|.|.|:..::     :||::
Yeast   555 SAATGAAVGAAVGAAALGASAFSRSSNNAFKNQDLFADGEASAQLSNATTEMANLSNQVNSLSKQ 619

Human   457 PKMLKCSNRKSLSPSGLKIQTGKKCDGQFR--------DQ-IK----FENKVTSNNKENVTECPK 508
            ..:  .:::||.:...||..|..|...|.:        || :|    .|.:|...||||.|...:
Yeast   620 ASI--TNDKKSRATQELKRVTEMKNSIQIKLNNLRSTHDQNVKQTEQLEAQVLQVNKENETLAQQ 682

Human   509 PCDTGCTGWNKTQGKDRLPLSTGPASRLAAKSPIRETMKESESSLDVSLQKKLETWEREKEKENL 573
                               |:...|:..||:|.:.|        |...||        |.:.:|.
Yeast   683 -------------------LAVSEANYHAAESKLNE--------LTTDLQ--------ESQTKNA 712

Human   574 ELDEFLFLEQAADEIS--FSSNSSFVLKILERDQQICKGHRMSSTPVKAVPQKTNPADPISHCNR 636
            ||.|         :|:  .|..:|...::.|:.||:.:...|..     |..|....:.::..|.
Yeast   713 ELKE---------QITNLNSMTASLQSQLNEKQQQVKQERSMVD-----VNSKQLELNQVTVANL 763

Human   637 SEDLDHTAREKESECEVAPKQLHSLSSADELREQPCKIRKAVQKSTSENQTEWNARDDEGVPNSD 701
            .:::|... ||.|......|:|:.                 .||:..|...:..|:..: :.|.|
Yeast   764 QKEIDGLG-EKISVYLTKQKELND-----------------YQKTVEEQHAQLQAKYQD-LSNKD 809

Human   702 SS-TDSEEQLDVTIKPSTEDRERGISSRED--------SPQVCDD----KGPFKDTRTQEDKRRD 753
            :. ||.|:||        |:|.|.|..:|:        ..::.||    |..| :...||.|.|:
Yeast   810 TDLTDREKQL--------EERNRQIEEQENLYHQHVSKLQEMFDDLSQRKASF-EKADQELKERN 865

Human   754 VD----------------------------------LDLSDKDYSSDESIMESIKHKVSEPS-RS 783
            ::                                  .|.:.|:.:|..::.|....|..|.: .:
Yeast   866 IEYANNVRELSERQMNLAMGQLPEDAKDIIAKSASNTDTTTKEATSRGNVHEDTVSKFVETTVEN 930

Human   784 SSLSLSKMDFDDERTWTDLEENLCNHDV-VLGNES----------TYGTPQTCYPN--------- 828
            |:|:::::..|:|:| ...|.::.:.|| .||::|          |....:|..||
Yeast   931 SNLNVNRVKDDEEKT-ERTESDVFDRDVPTLGSQSDSENANTNNGTQSGNETANPNLTETLSDRF 994

Human   829 ----NEIGILDKTIKRKIAPVKRGEDLSKSRRSRSPPTSELMMKFFPSLKPKPKSDSHLGNELKL 889
                ||.||            .|.:.|:.|..:.:|.:....::...:|:.:...::....:...
Yeast   995 DGDLNEYGI------------PRSQSLTSSVANNAPQSVRDDVELPETLEERDTINNTANRDNTG 1047

Human   890 NISQDQPPGD------NARSQVLREKIIELETEIEKFKAENASLAKLRIERESALEKLRKEIADF 948
            |:|  ..||:      .|.:.||..:..|:..:....|..|::      |...::..:::.....
Yeast  1048 NLS--HIPGEWEATPATASTDVLSNETTEVIEDGSTTKRANSN------EDGESVSSIQESPKIS 1104

Human   949 EQQKAK----ELARIEEFKKEEMRKLQKERKVFEKYTTAARTFPDKKERE-------------EI 996
            .|.|||    |...|:|...:|......:...||.    .|..|....:.             ||
Yeast  1105 AQPKAKTINEEFPPIQELHIDESDSSSSDDDEFED----TREIPSATVKTLQTPYNAQPTSSLEI 1165

Human   997 ---QTLKQQIADLREDLKRKETKWSSTHSRLRSQIQMLVRENTDLREEIKVMERFRLDAWKRAEA 1058
               |.:|..............:|.:||:|.|.      |::..|  :|...:|:         .|
Yeast  1166 HTEQVIKYPAPGTSPSHNEGNSKKASTNSILP------VKDEFD--DEFAGLEQ---------AA 1213

Human  1059 IESSLEVEKKDKLANTSVRFQNSQISSGTQVEKYK----------------KNYLPMQGNPP--- 1104
            :|       :|..|::...|:|  :::...:|:::                ...|....||.
Yeast  1214 VE-------EDNGADSESEFEN--VANAGSMEQFETIDHKDLDDELQMNAFTGTLTSSSNPTIPK 1269

Human  1105 ---RRSKSAPPRDLGN--------------LDKGQAASPREPLEPL 1133
               ::..::.|..:.|              .:..:.|:|..|.:|:
Yeast  1270 PQVQQQSTSDPAQVSNDEWDEIFAGFGNSKAEPTKVATPSIPQQPI 1315

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
CPAP	NP_060921.3	Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	190..211
		Alpha/beta-tubulin binding. /evidence=ECO:0000269|PubMed:19131341	319..394		20/89 (22%)
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	386..414		3/28 (11%)
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	436..479		10/47 (21%)
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	521..551		6/29 (21%)
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	611..789		42/225 (19%)
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	845..865		4/19 (21%)
		SMC_N	<886..1148	CDD:481474	52/310 (17%)
		Interaction with STIL. /evidence=ECO:0000269|PubMed:22020124, ECO:0000269|PubMed:25385835	895..1338		50/301 (17%)
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	1096..1153		9/58 (16%)
		Tcp10_C	1152..1180	CDD:462118
		Tcp10_C	1225..1253	CDD:462118
		Tcp10_C	1261..1289	CDD:462118
		Tcp10_C	1296..1325	CDD:462118
EDE1	NP_009506.1	EH	9..101	CDD:197477
		EH	128..221	CDD:197477
		EH	270..363	CDD:197477
		Smc	<589..>879	CDD:440809	79/368 (21%)
		COG4372	713..1052	CDD:443500	75/395 (19%)
		UBA_scEDE1_like	1345..1379	CDD:270471