DRSC/TRiP Functional Genomics Resources

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back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits


Protein Alignment CPAP and cpap

DIOPT Version :10

Sequence 1:NP_060921.3 Gene:CPAP / 55835 HGNCID:17272 Length:1338 Species:Homo sapiens
Sequence 2:XP_021334644.1 Gene:cpap / 568957 ZFINID:ZDB-GENE-030131-6323 Length:1124 Species:Danio rerio


Alignment Length:1415 Identity:467/1415 - (33%)
Similarity:678/1415 - (47%) Gaps:372/1415 - (26%)


- Green bases have known domain annotations that are detailed below.


Human     3 LMPTSSELNSGQ-NFLTQWMTNPSRAGVILNRGFPILEADKEKRAAVDISTSFPIKGTHFSDSFS 66
            :|.:.:.|..|| ||::.|:.:.:||||||: |.|...:....|::..:....|        ..|
Zfish     1 MMSSPAGLQQGQINFISHWVPDSTRAGVILH-GSPGDASSGSVRSSGSLVVQDP--------DDS 56

Human    67 FINEEDSLLEEQKLESNNPYKPQSDKSETHTAFPCIKKGPQVAACHSAPGHQE------ENKNDF 125
            ||::...|             |.|..|...:...|...|..     ..||..:      .::...
Zfish    57 FISQFAPL-------------PISRSSSCASVDMCSLGGGS-----KTPGETQLSDASLNSEMQS 103

Human   126 IPDLASEFKEGAYKDPLFKKLEQLKEVQQKKQEQLKRQQLEQLQRLMEEQEKLLTMVSGQCTLPG 190
            |.|:....::    .||..||||||::|.:.|||||..|.|||.|...|.::||.:         
Zfish   104 IQDILRNTRD----LPLIAKLEQLKQMQYRMQEQLKAHQQEQLLRQQREPQRLLAI--------- 155

Human   191 LSLLPDDQSQKHRSPGNTTTGERATCCFPSYVYPDPTQEETYPSNILSHEQSNFCRTAHGDFVLT 255
                          |.||.   ..|.|                                      
Zfish   156 --------------PQNTA---ETTVC-------------------------------------- 165

Human   256 SKRASPNLFSEAQYQEAPVEKNNLKEENRNHPTGESILCWEKVTEQIQEANDKNLQKHDDSSEVA 320
              ...|::.:             |..|:.:|...|..|  :..||      |:.:.:.:..||. 
Zfish   166 --NREPSVVA-------------LNTEHDSHYEFEESL--QSTTE------DQTMYRKESDSEP- 206

Human   321 NIEERPIKAAIGERKQTFEDYLEEQIQLEEQELKQKQLKEAEGPLPIKAKPKQPFLKRGEGLARF 385
              ::||||:..|.|  |||:.||||:::|.|:|..      |.|.....|.|:||||||||||||
Zfish   207 --QDRPIKSGFGGR--TFEEILEEQLKMENQKLTN------ENPPAKSVKVKRPFLKRGEGLARF 261

Human   386 TNAKSKFQKGKES----KLVTNQSTSEDQPL--------------FKMDRQQLQRKTALKNKELC 432
            |..|:.....::|    |..:.|:..:.|.|              .|.....:|||||:.|||..
Zfish   262 TRGKATVPSNRKSPPNPKPSSGQNPKKSQVLDMKSKRNSINKSEGSKSTHPMIQRKTAVLNKENF 326

Human   433 ADNPILKKDSKARTKSGSVTLSQKPKMLKCSNRKSLSPSGLKIQTGKKCDGQFRDQIKFENKVTS 497
            ..|          ..:|.||            :.:|.|..|....|:.. |....||..:....|
Zfish   327 PQN----------KTTGPVT------------KMTLQPHVLVAHQGQNM-GSISAQILPKPDPLS 368

Human   498 NNKENVTECPKPCDTGCTGWNKTQGKDRLPLSTGPASRLAAKSPIRETMKESESSLDVSLQKKLE 562
            |.|.| ...|..|       ||.:..:|                |::....:|:|.:|...::.|
Zfish   369 NMKIN-NATPTDC-------NKERECNR----------------IKDNASVAENSFEVWFTERRE 409

Human   563 TWEREKEKENLELDEFLFLEQAADEISFSSNSSFVLKILERDQQICKGHRMSSTPVKAVPQKTNP 627
            .||::.::|..||.||..||:|||||||||||||:..:|:||::     |:||||:|:..|.|.|
Zfish   410 HWEQDHKRERAELGEFELLERAADEISFSSNSSFISTLLQRDRR-----RLSSTPIKSTGQSTLP 469

Human   628 ADPISHCNRSEDLDHTAREKESECEVAPKQL--HSLSSADELREQPCKIRKAVQKSTSENQTEWN 690
                     |:.|..||         ||..:  |        |.....|..|:||.....:.:..
Zfish   470 ---------SQALGPTA---------APGLMLGH--------RAPAPPINTAIQKDIVSIELKEL 508

Human   691 ARDDEGVPNSDSSTDSEE---------------QLDVTI---KPSTEDRERGISSRE--DSPQVC 735
            ..::......|||..:.|               |:.:|:   |.:.:||: |.||.|  |.....
Zfish   509 CHEETDEKFDDSSCSNSELEPLSNISNPPINHFQVPITLPYDKRTYQDRD-GASSPEGDDRNSSH 572

Human   736 DDKGPFKDTRTQEDKRRDVDLDLSDKDYSSDESIMESIKHKVSEPSRSSSLSLSKMDFDDERTWT 800
            ::....||:|||                                           ::|||:.||.
Zfish   573 NEDSTLKDSRTQ-------------------------------------------LEFDDDDTWN 594

Human   801 DLE-ENLCNHDVVLGNESTYGTPQTCYPNNEIGILDKTIKRKIA------PVKRGEDLSKSRRSR 858
            |.| |:.|              |....|:      ::.:|||:|      || .|...:.:.|:.
Zfish   595 DPEDESSC--------------PVEESPS------ERMLKRKVAFSKGVKPV-GGSPKAGANRNE 638

Human   859 SPPTSELMMKFFPSLKPKPKSDSHLGNELKLNISQDQPPGDN-ARSQVLREKIIELETEIEKFKA 922
            :|.||:|:.|.||:|||||       :.:.:...|::|..:. |:|::|||:::|||||||:||:
Zfish   639 APSTSQLVAKLFPALKPKP-------SPVMMPEPQNKPSEEGAAQSRLLRERLVELETEIERFKS 696

Human   923 ENASLAKLRIERESALEKLRKEIADFEQQKAKELARIEEFKKEEMRKLQKERKVFEKYTTAARTF 987
            |||:||:|:.|.:...|.|:|:.||||:::.:|.|:.||:|.||.:|:|:|:|:|||:....|..
Zfish   697 ENAALARLKQENQDIRENLKKDKADFEKKRIEETAKWEEYKSEEYKKMQREKKLFEKHAATVRAR 761

Human   988 PDKKEREEIQTLKQQIADLREDLKRKETKWSSTHSRLRSQIQMLVRENTDLREEIKVMERFRLDA 1052
            |||:||:|||.||||:..::|||:::|.:||:|..|||.|::.|..|||.||::::.:|:.||.|
Zfish   762 PDKQERDEIQALKQQLNMMQEDLRKREARWSNTQKRLRQQVESLSSENTSLRDQVRTLEKLRLSA 826

Human  1053 WKRAEAIESSLEVEKKDKLANTSVRFQNSQISSGTQVEKYKKNYLPMQGNPPRRSKSAPPRDLGN 1117
            ||.||.       ||:...::||    :|:.|:|::....|......:||..|  |.:|...:..
Zfish   827 WKSAEK-------EKEKGRSSTS----SSRTSTGSKPTDSKSPSHSSKGNSSR--KGSPETQISL 878

Human  1118 LDKGQAASPRE---------PL----------------EPLNFPDPEYKEEEEDQDIQGEISHPD 1157
            .|.......:|         ||                .|||...|:.....:..:.|.||...|
Zfish   879 TDSAFFPEVKETQSFKSELSPLVNQSSGVLVMNERSQDAPLNNSFPKLTITGQTNEKQEEIMQSD 943

Human  1158 GKVEKVYKNGCRVILFPNGTRKEVSADGKTITVTFFNGDVKQVMPDQRVIYYYAAAQTTHTTYPE 1222
            .|:||:..:|.|:::||||||||:||||:|:.|.|||||||..|||||||||||.|||||.|||:
Zfish   944 SKIEKMLPDGGRLVVFPNGTRKELSADGQTVKVMFFNGDVKHTMPDQRVIYYYAEAQTTHITYPD 1008

Human  1223 GLEVLHFSSGQIEKHYPDGRKEITFPDQTVKNLFPDGQEESIFPDGTIVRVQRDGNKLIEFNNGQ 1287
            |:|||.|.:.|.|||:|||||||||||||||.|.|||:|||:..||||:::..||:|:|:||.||
Zfish  1009 GMEVLQFPNNQTEKHFPDGRKEITFPDQTVKTLHPDGREESVLTDGTIIQLNPDGSKVIQFNTGQ 1073

Human  1288 RELHTAQFKRREYPDGTVKTVYANGHQETKYRSGRIRVKDKEGNVLMDTE 1337
            ||:|||.|||||||||||||||::|.|||:|.:||:|:||.:|.|:|||:
Zfish  1074 REIHTADFKRREYPDGTVKTVYSDGRQETQYPTGRVRLKDPQGKVIMDTK 1123

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
CPAPNP_060921.3 Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 190..211 3/20 (15%)
Alpha/beta-tubulin binding. /evidence=ECO:0000269|PubMed:19131341 319..394 34/74 (46%)
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 386..414 7/45 (16%)
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 436..479 6/42 (14%)
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 521..551 2/29 (7%)
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 611..789 40/199 (20%)
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 845..865 6/19 (32%)
SMC_N <886..1148 CDD:481474 103/287 (36%)
Interaction with STIL. /evidence=ECO:0000269|PubMed:22020124, ECO:0000269|PubMed:25385835 895..1338 229/469 (49%)
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 1096..1153 14/81 (17%)
Tcp10_C 1152..1180 CDD:462118 14/27 (52%)
Tcp10_C 1225..1253 CDD:462118 21/27 (78%)
Tcp10_C 1261..1289 CDD:462118 15/27 (56%)
Tcp10_C 1296..1325 CDD:462118 21/28 (75%)
cpapXP_021334644.1 YhaN 665..>836 CDD:443752 84/177 (47%)
Tcp10_C 937..966 CDD:462118 14/28 (50%)
Tcp10_C 1011..1039 CDD:462118 21/27 (78%)
Tcp10_C 1047..1076 CDD:462118 16/28 (57%)
Tcp10_C 1082..1110 CDD:462118 21/27 (78%)

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