Protein Alignment CPAP and Sas-4

DIOPT Version :10

• Sequence 1: NP_060921.3
• Gene: CPAP / 55835
• HGNCID: 17272
• Length: 1338
• Species: Homo sapiens
• Sequence 2: NP_649701.2
• Gene: Sas-4 / 40859
• FlyBaseID: FBgn0011020
• Length: 901
• Species: Drosophila melanogaster
• Alignment Length: 1145
• Identity: 275/1145 - (24%)
• Similarity: 447/1145 - (39%)
• Gaps: 337/1145 - (29%)

Human   281 EENRNHPTGESILCWEKVTEQI------QEANDKNLQKHDDSSEV-ANIEERPIKAAIGERKQTF 338
            :|....|.|.. |..|.:.:::      |:...:.||:...:..| ..:|:|.:...:|...|..
  Fly     2 QEAGESPVGMP-LSQEAIAQRLAALSRWQDEQKRLLQERQSNHRVLLGLEQRNMYKMLGLLHQET 65

Human   339 EDY----LEEQIQLEEQELKQKQL----KEAEGPL----PIKAKPKQPFLKRGEGLA-------- 383
            |.:    |||..  ||..::..:|    .|.|..:    |..||||:|||:|||||.
  Fly    66 ESHENSVLEEWD--EEHSIQMPRLAADPDEHEPEISMADPQPAKPKRPFLRRGEGLKQRFKINPD 128

Human   384 ----------RFTNAKSKFQKGKESK-LVTNQSTSEDQP-----------LFKMDRQQLQRKTAL 426
                      :|.||..:|:..:..| ::..|..|...|           |..::.|:.|:  .|
  Fly   129 QLRLENLPRYKFANAHPQFRTPQMKKGILKKQVKSPPNPAPPPAPKPSAQLDDLNEQRFQQ--ML 191

Human   427 KNKELCADNPILKKDSKARTKSGSVTLSQKPKMLKCSNRKSLSPSGLKIQTGKKCDGQFRDQIKF 491
            ..|..|:..|.||....:.|.:.|.:    |::                        :|.:|...
  Fly   192 IGKNACSSTPDLKSSYASSTTASSTS----PRV------------------------RFVEQKSR 228

Human   492 ENKVTSNNKENVTECPKPCDTGCTGWNK---TQGKDRLPLSTGPASRLAAKSPIRETMKESESSL 553
            ..:.|..:.|..:|. .|....|  |.|   ||       |..||......:.||   .|.:|::
  Fly   229 AGQTTHADDEASSEA-SPMTGVC--WAKVLDTQ-------SIKPAQIQRRSAQIR---VEDDSNV 280

Human   554 DVSLQKKLETWEREKEKENLELDEFLFLEQAADEISFSSNSSFVLKILERDQQICKGHRMSSTPV 618
            .:                      |..|||.|.|.:...|||.:...:.|..
  Fly   281 SI----------------------FELLEQKATEGNIDMNSSCIRTFMARKD------------- 310

Human   619 KAVPQKTNPADPISHCNRSEDLDHTAREKESECEVAPKQLHSLSSADELREQPCKIRKAVQKSTS 683
                |:...||         |.||.         |..:|:.      ::|.||     .|.:...
  Fly   311 ----QRRRVAD---------DSDHI---------VVTQQVR------QMRLQP-----QVDQMLV 342

Human   684 ENQTEWNARDDEGVPNSDSSTDSEEQLDVTIKP----STEDRERGISSREDSPQVCDDKGPFKDT 744
            :...|.:..|.|  |:||.:        :|:.|    :|:.|.|                 |.|:
  Fly   343 QELQEGDEEDTE--PSSDQT--------LTMTPIQVGNTKVRVR-----------------FSDS 380

Human   745 RTQEDKRRDVDLDLSDKDYSSDESIMESIKHKVSEPSRSSSLSLSKMDFDDERTWTDLEENLCNH 809
            .             ...:||...|:.:....::.|..:|:             .:..||:
  Fly   381 N-------------DTHEYSDATSLNDGSNIQLFEQFKSA-------------LFQALEQ----- 414

Human   810 DVVLGNESTYGTPQTCYPNNEIGILDKTIKRKIAPVKRGEDLSKSRRSRSPPTSELMMKFFPSLK 874
                                         |:|.:|         |:.|..|.|.:|..|
  Fly   415 -----------------------------KKKSSP---------SKESDEPITKDLQEK------ 435

Human   875 PKPKSDSHLGNELKLNISQDQPPGDNARSQVLREKIIELETEIEKFKAENASLAKLRIERESALE 939
                                        :.::|.::.||||||..||.:||.|.:||.:.|....
  Fly   436 ----------------------------ANLVRTRLEELETEIATFKEQNAQLLRLRQQHELEKA 472

Human   940 KLRKEIADFEQQKAKELARIEEFKKEEMRKLQKERKVFEKYTTAARTFPDKKEREEIQTLKQQIA 1004
            |..::..:..::...|..:.|.:..:|..|:::||:.||:.....::..:.||::||..|||::.
  Fly   473 KCTQDHMEAMERVHDEKIQAEIYLHDERMKIEEERRKFEQQMRLQKSNANSKEKKEIAALKQEVE 537

Human  1005 DLREDLKRKETKWSSTHSRLRSQIQMLVRENTDLREEIKVM--ERFRLDAWKRAEAIESSLEVEK 1067
            .|:..||:||....|..:|||:|::...:|..:.|:||:::  |..||:    .|.::...|...
  Fly   538 GLQLQLKQKEQAHVSAQARLRAQLRASEKEQRNYRDEIELLRKENKRLE----QELVKIGRENNS 598

Human  1068 K--DKLANTSVRFQNSQISSGTQVEKYKKNYLPMQGNPPRRSKSAPPRDLGNLDKGQAAS----- 1125
            |  .::.....|.....:.|.|..:...:|....|.......|.|..|:..|..:...::
  Fly   599 KMLQEINRNIARLAPKVLPSATMSDILDENGRRTQSLDGTAGKPAKQREAQNRRQSSGSAQVRSR 663

Human  1126 ----PREPLEPLNFPDPEYKEEE--EDQDIQGEISHP-------------DGKVEKVYKNGCRVI 1171
                .|....|... |..|....  |.:::|..::.|             |.|.|....:|.:.|
  Fly   664 SRSLSRNKKTPYAL-DESYASSSSVESEEVQPPVTAPKAATPPPAANSSSDFKREITNADGSKDI 727

Human  1172 LFPNGTRKEVSADGKTITVTFFNGDVKQV-MPDQRVIYYYAAAQTTHTTYPEGLEVLHFSSGQIE 1235
            .:|||..|::||||..:.:.:||.|:|:. :.:..|.||||...|.||:|.:|||:|.|.:||.|
  Fly   728 WYPNGNLKKISADGMNLRMLYFNKDIKETNIREGTVKYYYAETNTWHTSYLDGLEILEFPNGQTE 792

Human  1236 KHYPDGRKEITFPDQTVKNLFP---DGQEESIFPDGTIVRVQRDGNKLIEFNNGQRELHTAQFKR 1297
            ....||..||.||:.::|.:.|   :..||..:.|||.:...|:|:|::...|||:|:||...||
  Fly   793 HRRKDGTVEIHFPNNSIKIVDPSDTEKLEEWRYADGTHLVQLRNGDKILNLPNGQKEIHTKLNKR 857

Human  1298 REYPDGTVKTVYANGHQETKYRSGRIRVKDKEGNVLMDTE 1337
            |||||||||.||.:|.|||:|.:||:|:|||:|.::|||:
  Fly   858 REYPDGTVKLVYPDGSQETRYSNGRVRLKDKDGKLIMDTD 897

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
CPAP	NP_060921.3	Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	190..211
		Alpha/beta-tubulin binding. /evidence=ECO:0000269|PubMed:19131341	319..394		31/105 (30%)
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	386..414		8/39 (21%)
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	436..479		6/42 (14%)
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	521..551		7/29 (24%)
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	611..789		30/181 (17%)
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	845..865		4/19 (21%)
		SMC_N	<886..1148	CDD:481474	65/276 (24%)
		Interaction with STIL. /evidence=ECO:0000269|PubMed:22020124, ECO:0000269|PubMed:25385835	895..1338		151/475 (32%)
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	1096..1153		11/67 (16%)
		Tcp10_C	1152..1180	CDD:462118	9/40 (23%)
		Tcp10_C	1225..1253	CDD:462118	12/27 (44%)
		Tcp10_C	1261..1289	CDD:462118	11/27 (41%)
		Tcp10_C	1296..1325	CDD:462118	20/28 (71%)
Sas-4	NP_649701.2	Smc	<435..>654	CDD:440809	61/256 (24%)
		YwqK	731..900	CDD:442097	78/167 (47%)
		Tcp10_C	821..850	CDD:462118	11/28 (39%)
		Tcp10_C	856..884	CDD:462118	20/27 (74%)