DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment CENPJ and Cenpj

DIOPT Version :9

Sequence 1:	NP_060921.3	Gene:	CENPJ / 55835	HGNCID:	17272	Length:	1338	Species:	Homo sapiens
Sequence 2:	NP_001382046.1	Gene:	Cenpj / 305909	RGDID:	1310464	Length:	1344	Species:	Rattus norvegicus

Alignment Length:	1352	Identity:	976/1352 - (72%)
Similarity:	1107/1352 - (81%)	Gaps:	24/1352 - (1%)

- Green bases have known domain annotations that are detailed below.

Human     1 MFLMPTSSELNSGQNFLTQWMTNPSRAGVILNRGFPILEADKEKRAAVDISTSFPIKGTHFSDSF 65
            |||||||||||:||||||||||:||||||||||.||||:|| ||:||..:|.|||:|..|||.||
  Rat     3 MFLMPTSSELNTGQNFLTQWMTSPSRAGVILNREFPILDAD-EKQAATTVSASFPVKAAHFSSSF 66

Human    66 SFINEEDSLLEEQKLESNNPYKPQSDKSETHTAFPCIKKGPQVAACHSAPGHQEENKNDFIPDLA 130
            |..:||||..|||.||:..||||:|:..|.|.....:::.| :|:|..|||.||.|:|...|||.
  Rat    67 SISSEEDSFHEEQTLEAGRPYKPRSEDPEAHPVSASVRREP-IASCQDAPGCQEGNRNAATPDLK 130

Human   131 SEFKEGAYKDPLFKKLEQLKEVQQKKQEQLKRQQLEQLQRLMEEQEKLLTMVSGQCTLPGLSLLP 195
            |||||.|.|:|||||||||||:|||||||||||||||||||||||||||||||||...|| ||||
  Rat   131 SEFKEVANKNPLFKKLEQLKEIQQKKQEQLKRQQLEQLQRLMEEQEKLLTMVSGQHMFPG-SLLP 194

Human   196 DDQSQKHRSPGNTTTGERATCCFPSYVYPDPTQEETYPSNILSHEQSNFCRTAHGDFVLTSKRAS 260
            |:.||||||||::.:|||||...||  ||:|||:.:..|::|..|||||||....|.|||||.||
  Rat   195 DELSQKHRSPGDSASGERATLSPPS--YPNPTQDNSRASSLLPDEQSNFCRATQQDSVLTSKNAS 257

Human   261 PNLFSEAQYQEAPVEKNNLKEENRNHPTGESIL-CWEKVTEQIQEANDKNLQKHDDSSEVANIEE 324
             :||.|:||.||.|.:|:||||:.|||:||..| ||||...:.||..|.|||:..|||.|.||||
  Rat   258 -DLFHESQYHEAHVRRNDLKEESHNHPSGEGALPCWEKKMGKSQEGKDVNLQRSRDSSGVVNIEE 321

Human   325 RPIKAAIGERKQTFEDYLEEQIQLEEQELKQKQLKEAEGPLPIKAKPKQPFLKRGEGLARFTNAK 389
            |||||||.|::|||||||||||:|||:||:||||:||||||..|.||||||||||||||||||||
  Rat   322 RPIKAAIREKQQTFEDYLEEQIRLEERELRQKQLQEAEGPLLTKMKPKQPFLKRGEGLARFTNAK 386

Human   390 SKFQKGKESKLVTNQSTSEDQPLFKMDRQQLQRKTALKNKELCADNPILKKDSKARTKSGSVTLS 454
            .||||||||||.:.||.||.|.:.|:|||.|||||||.|::||||...:|||||||:|:||.:|.
  Rat   387 CKFQKGKESKLASTQSPSEQQSVPKVDRQHLQRKTALINRDLCADTTSVKKDSKARSKAGSASLR 451

Human   455 QKPKMLKCSNRKSLSPSGLKIQTGKKCDGQFRDQIKFENKVTSNNKENVTECPKPCDTGCTGWNK 519
            ||||:.|.:.|.||||.|.|:|||||||||||.|:|.|..|.:||||||....||...||..|||
  Rat   452 QKPKVTKTNRRDSLSPPGRKVQTGKKCDGQFRPQVKLERNVPTNNKENVPAYIKPWGAGCKVWNK 516

Human   520 TQGKDRLPLSTGPASRLAAKSPIRETMKESESSLDVSLQKKLETWEREKEKENLELDEFLFLEQA 584
            |||:|||||||||...:.::|.:.||.:::|||||:|||||||.|||||||||||||||||||:|
  Rat   517 TQGRDRLPLSTGPVGCVVSRSLVPETDRQTESSLDISLQKKLENWEREKEKENLELDEFLFLERA 581

Human   585 ADEISFSSNSSFVLKILERDQQICKGHRMSSTPVKAV-PQKTNPADPISHCNRSE-DLDHTAREK 647
            |||||||||||||||||||||||.:|||:|||||||| |||...|||....|.|| .....|.|.
  Rat   582 ADEISFSSNSSFVLKILERDQQIYEGHRLSSTPVKAVQPQKAQQADPWGQSNHSEVPRPSVAHED 646

Human   648 ESECEVAPKQLHSLSSADELREQPCKI-RKAVQKSTSENQTEWNARDDEGVPNSDSSTDSEEQLD 711
            |||.|.  ..|...|.:..|||..||: :||.|.||||||..|:|.|.: |.|||||::|||. |
  Rat   647 ESEFEA--MLLSRGSGSPGLRELSCKLSKKAFQNSTSENQGRWDAGDGD-VANSDSSSESEEH-D 707

Human   712 VTIKPSTEDRERGISSREDSPQVCDDKGPFKDTRTQEDKRRDVDLDLSDKDYSSDESI-MESIKH 775
            :|||||||..:|..|:|||||||||.|||.:||..|||:.||.|||||||:.|||||: :||:..
  Rat   708 ITIKPSTEAEDRVFSNREDSPQVCDAKGPSRDTGAQEDQWRDADLDLSDKECSSDESVTVESLSS 772

Human   776 KVSEPSR-SSSLSLSKMDFDDERTWTDLEENLCNHDVVLGNESTYGTPQT-CYPNNEIGILDKTI 838
            :|.||.| .||...||:||||||:|.|||||...|.||...|:..||.|| |:..:|..:|||||
  Rat   773 QVLEPLRLPSSHDGSKVDFDDERSWADLEENPHEHGVVPREEAMSGTSQTHCHSTSEGCVLDKTI 837

Human   839 KRKIAPVKRGEDLSKSRRSRSPPTSELMMKFFPSLKPKPKSDSHLGNELKLNISQDQPPGDNARS 903
            ||||||||:|||.|||.||.|||.|:||:|||||||||||.|||:.||.||::||||||||:.||
  Rat   838 KRKIAPVKKGEDFSKSDRSVSPPPSDLMVKFFPSLKPKPKLDSHVENEPKLSLSQDQPPGDSVRS 902

Human   904 QVLREKIIELETEIEKFKAENASLAKLRIERESALEKLRKEIADFEQQKAKELARIEEFKKEEMR 968
            ||||||:||||:|||||||||.||||||||||||||||||||||||||||:|||||||:||||.|
  Rat   903 QVLREKVIELESEIEKFKAENTSLAKLRIERESALEKLRKEIADFEQQKARELARIEEYKKEETR 967

Human   969 KLQKERKVFEKYTTAARTFPDKKEREEIQTLKQQIADLREDLKRKETKWSSTHSRLRSQIQMLVR 1033
            |||||||||||||.|||||||||||||||.|||||.:|:||||||||||||||.||||||:|||:
  Rat   968 KLQKERKVFEKYTAAARTFPDKKEREEIQALKQQIQELQEDLKRKETKWSSTHGRLRSQIEMLVK 1032

Human  1034 ENTDLREEIKVMERFRLDAWKRAEAIESS------LEVEKKDKLANTSVRFQNSQISSGTQVEKY 1092
            |||||||||||||||||:|||||||||:|      :...|||:..|:|::||.|..|.|.|.|||
  Rat  1033 ENTDLREEIKVMERFRLEAWKRAEAIENSPKACQYIMATKKDESMNSSIQFQKSHASLGVQGEKY 1097

Human  1093 KKNYLPMQGNPPRRSKSAPPRDLGNLDKGQAASPREPLEPLNFPDPEYK-EEEEDQDIQGEISHP 1156
            ||.|||.|||..|||||.||||||:|||||||.|||||:|:||||.||| :||::::|||||:||
  Rat  1098 KKKYLPAQGNSSRRSKSVPPRDLGSLDKGQAALPREPLQPVNFPDLEYKNKEEKEEEIQGEINHP 1162

Human  1157 DGKVEKVYKNGCRVILFPNGTRKEVSADGKTITVTFFNGDVKQVMPDQRVIYYYAAAQTTHTTYP 1221
            ||||||||||||||:|||||||||||||||:||||||||||||||||:||:||||||||||||||
  Rat  1163 DGKVEKVYKNGCRVVLFPNGTRKEVSADGKSITVTFFNGDVKQVMPDERVVYYYAAAQTTHTTYP 1227

Human  1222 EGLEVLHFSSGQIEKHYPDGRKEITFPDQTVKNLFPDGQEESIFPDGTIVRVQRDGNKLIEFNNG 1286
            ||||||||||||||||:|||||||||||||:|.||.||||||||||||||||||||||:||||||
  Rat  1228 EGLEVLHFSSGQIEKHFPDGRKEITFPDQTIKTLFADGQEESIFPDGTIVRVQRDGNKIIEFNNG 1292

Human  1287 QRELHTAQFKRREYPDGTVKTVYANGHQETKYRSGRIRVKDKEGNVLMDTEL 1338
            ||||||||||||||||||||||||||||||||.|||:|||||:||||||||:
  Rat  1293 QRELHTAQFKRREYPDGTVKTVYANGHQETKYTSGRVRVKDKDGNVLMDTEM 1344

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CENPJ	NP_060921.3	Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	190..211		14/20 (70%)
		Alpha/beta-tubulin binding. /evidence=ECO:0000269\|PubMed:19131341	319..394		62/74 (84%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	386..414		19/27 (70%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	436..479		25/42 (60%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	521..551		14/29 (48%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	611..789		102/182 (56%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	845..865		14/19 (74%)
		Interaction with STIL. /evidence=ECO:0000269\|PubMed:22020124, ECO:0000269\|PubMed:25385835	895..1338		380/449 (85%)
		Ax_dynein_light	<921..1012	CDD:287215	81/90 (90%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	1096..1153		42/57 (74%)
		Tcp10_C	1161..1335	CDD:284589	161/173 (93%)
Cenpj	NP_001382046.1	Smc	<901..>1046	CDD:224117	130/144 (90%)
		Tcp10_C	1158..1187	CDD:399882	26/28 (93%)
		Tcp10_C	1227..1260	CDD:399882	30/32 (94%)
		Tcp10_C	1264..1297	CDD:399882	31/32 (97%)
		Tcp10_C	1301..1331	CDD:399882	27/29 (93%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C83693847
Domainoid	1	1.000	1404	1.000	Domainoid score	I690
eggNOG	0	0.000	Not matched by this tool.
HGNC	1	1.500	-	-
Hieranoid	1	1.000	-	-
Homologene	1	1.000	-	-		H10204
Inparanoid	1	1.050	1744	1.000	Inparanoid score	I2010
NCBI	1	1.000	-	-
OMA	1	1.010	-	-		QHG38507
OrthoDB	1	1.010	-	-		D122802at2759
OrthoFinder	1	1.000	-	-		FOG0009529
OrthoInspector	1	1.000	-	-		oto129948
orthoMCL	1	0.900	-	-		OOG6_105142
Panther	1	1.100	-	-	LDO	PTHR10331
Phylome	1	0.910	-	-
SonicParanoid	1	1.000	-	-		X6202
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
	16	16.410