DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment CPAP and Cpap

DIOPT Version :10

Sequence 1:	NP_060921.3	Gene:	CPAP / 55835	HGNCID:	17272	Length:	1338	Species:	Homo sapiens
Sequence 2:	NP_001014996.2	Gene:	Cpap / 219103	MGIID:	2684927	Length:	1344	Species:	Mus musculus

Alignment Length:	1359	Identity:	989/1359 - (72%)
Similarity:	1113/1359 - (81%)	Gaps:	36/1359 - (2%)

- Green bases have known domain annotations that are detailed below.

Human     1 MFLMPTSSELNSGQNFLTQWMTNPSRAGVILNRGFPILEADKEKRAAVDISTSFPIKGTHFSDSF 65
            ||||||||||||||||||||||:|||||||||||||||||| :|:||.::|||||.|.||||:||
Mouse     1 MFLMPTSSELNSGQNFLTQWMTSPSRAGVILNRGFPILEAD-DKQAATNVSTSFPAKATHFSNSF 64

Human    66 SFINEEDSLLEEQKLESNNPYKPQSDKSETHTAFPCIKKGPQVAACHSAPGHQEENKNDFIPDLA 130
            |..:||||..||||||:..||||.|:..|....||.::|.| :|:...|||.||:|.||..|.|.
Mouse    65 SISSEEDSFHEEQKLEAGGPYKPWSENPEAPPVFPSVRKEP-IASRQDAPGCQEDNNNDLTPHLE 128

Human   131 SEFKEGAYKDPLFKKLEQLKEVQQKKQEQLKRQQLEQLQRLMEEQEKLLTMVSGQCTLPGLSLLP 195
            |||||.|.|:|||||||||||:|||||||||||||||||||||||||||||||.|...|| :|||
Mouse   129 SEFKEVANKNPLFKKLEQLKEIQQKKQEQLKRQQLEQLQRLMEEQEKLLTMVSAQHAFPG-TLLP 192

Human   196 DDQSQKHRSPGNTTTGERATCCFPSYVYPDPTQEETYPSNILSHEQSNFCRTAHGDFVLTSKRAS 260
            |||||||||||:.|        .|.:.|.:||||.:..||:|..||||||| |..|.|||||.||
Mouse   193 DDQSQKHRSPGDLT--------LPPHSYSNPTQENSCASNVLPDEQSNFCR-ATQDSVLTSKNAS 248

Human   261 PNLFSEAQYQEAPVEKNNLKEENRNHPTGESIL-CWEKVTEQIQEANDKNLQKHDDSSEVANIEE 324
             :||.|:|||||.|::|:||||:..||:||..| .|||...:.||..|.||||..|||||.||:|
Mouse   249 -DLFYESQYQEAHVKRNDLKEESPAHPSGEGALPRWEKKMGRSQEGKDVNLQKCGDSSEVVNIDE 312

Human   325 RPIKAAIGERKQTFEDYLEEQIQLEEQELKQKQLKEAEGPLPIKAKPKQPFLKRGEGLARFTNAK 389
            ||||||:.|::|||||||||||||||:||:||||:||||||..|.||||||||||||||||||||
Mouse   313 RPIKAAVREKQQTFEDYLEEQIQLEERELRQKQLQEAEGPLLAKTKPKQPFLKRGEGLARFTNAK 377

Human   390 SKFQKGKESKLVTNQSTSEDQPLFKMDRQQLQRKTALKNKELCADNPILKKDSKARTKSGSVTLS 454
            |||||||||||.:.||.|||||..|:|||.|||||||.||:|||:.|.:|||||||.|:|..:|.
Mouse   378 SKFQKGKESKLASTQSPSEDQPGSKVDRQHLQRKTALINKDLCAETPTVKKDSKARPKAGFASLR 442

Human   455 QKPKMLKCSNRKSLSPSGLKIQTGKKCDGQFRDQIKFENKVTSNNKENVTECPKPCDTGCTGWNK 519
            ||||:.|.:.|:||||.|||:|||||.|||||.|:|.|....::|||||..|.||.|.||..|:|
Mouse   443 QKPKVTKTNMRESLSPPGLKVQTGKKRDGQFRHQVKGERNAHASNKENVPACIKPWDAGCKMWSK 507

Human   520 TQGKDRLPLSTGPASRLAAKSPIRETMKESESSLDVSLQKKLETWEREKEKENLELDEFLFLEQA 584
            |||::||||||||...:.::||||||.:|:|||||.|||||||.|||||||||||||||||||:|
Mouse   508 TQGRERLPLSTGPVGCVVSRSPIRETDRETESSLDFSLQKKLEIWEREKEKENLELDEFLFLERA 572

Human   585 ADEISFSSNSSFVLKILERDQQICKGHRMSSTPVKAVPQK-TNPADPISHCNRSEDLDH-TAREK 647
            ||||||||||||||:|||||||||.|||:||||||||.|: ...|||....|.||...: .|.|.
Mouse   573 ADEISFSSNSSFVLRILERDQQICDGHRLSSTPVKAVQQREAQQADPRGQSNCSEIPRYGVAHEN 637

Human   648 ESECEVAPKQLHSLSSADELREQPCK-IRKAVQKSTSENQTEWNARDDEGVPNSDSSTDSEEQLD 711
            |||||.......| .|.|.|||..|| ..||.|.||||.|::|:|||| ||.||||||:||||.|
Mouse   638 ESECEAMLLSWGS-GSPDGLRELSCKRSMKAFQTSTSEIQSQWDARDD-GVANSDSSTESEEQHD 700

Human   712 VTIKPSTEDRERGISSREDSPQVCDDKGPFKDTRTQEDKRRDVDLDLSDKDYSSDES-IMESIKH 775
            :|||||||..:|..|:|||||||||.|||.:||..||||.||.|||||||:.||||| |:||:.:
Mouse   701 ITIKPSTEVGDRVFSNREDSPQVCDAKGPIRDTGAQEDKWRDADLDLSDKECSSDESVIVESLNN 765

Human   776 KVSEPSR-SSSLSLSKMDFDDERTWTDLEENLCNHDVVLGNESTYGTPQT-CYPNNEIGILDKTI 838
            ||.||.| .||.:.||:||||||:|||||||...|.|:...|:.|||||| |:..:|..:|||||
Mouse   766 KVLEPLRLPSSQAGSKIDFDDERSWTDLEENPYEHGVIHREEAIYGTPQTQCHSKSEGCVLDKTI 830

Human   839 KRKIAPVKRGEDLSKSRRSRSPPTSELMMKFFPSLKPKPKSDSHLGNELKLNISQDQPP------ 897
            ||||||||:|||....||...||.|:||:|||||||||||.||||.||.|||:||||||
Mouse   831 KRKIAPVKKGEDFKCDRRISPPPPSDLMVKFFPSLKPKPKLDSHLENESKLNLSQDQPPEFMVCF 895

Human   898 -GDNARSQVLREKIIELETEIEKFKAENASLAKLRIERESALEKLRKEIADFEQQKAKELARIEE 961
             ||:.||||||||:.|||:|||||||||.||||||||||||||||||||||||||||:|||||||
Mouse   896 IGDSVRSQVLREKVTELESEIEKFKAENTSLAKLRIERESALEKLRKEIADFEQQKARELARIEE 960

Human   962 FKKEEMRKLQKERKVFEKYTTAARTFPDKKEREEIQTLKQQIADLREDLKRKETKWSSTHSRLRS 1026
            ::|||.||||||||||||||.|||||||||||||||.||||||||:|||||||||||||.|||||
Mouse   961 YRKEETRKLQKERKVFEKYTAAARTFPDKKEREEIQALKQQIADLQEDLKRKETKWSSTQSRLRS 1025

Human  1027 QIQMLVRENTDLREEIKVMERFRLDAWKRAEAIESS------LEVEKKDKLANTSVRFQNSQISS 1085
            ||:|||:|||||||||||||||||||||||||:|:|      :...|||:..|:|.:||.|.:||
Mouse  1026 QIEMLVKENTDLREEIKVMERFRLDAWKRAEAMENSPKACQYMMATKKDESMNSSFQFQKSHVSS 1090

Human  1086 GTQVEKYKKNYLPMQGNPPRRSKSAPPRDLGNLDKGQAASPREPLEPLNFPDPEYK-EEEEDQDI 1149
            |.|||||||.|||.|||..||.|||||||||:.||||||.|||||:.:||||.||| :||::::|
Mouse  1091 GVQVEKYKKKYLPAQGNLSRRIKSAPPRDLGSSDKGQAALPREPLQQVNFPDLEYKNKEEKEEEI 1155

Human  1150 QGEISHPDGKVEKVYKNGCRVILFPNGTRKEVSADGKTITVTFFNGDVKQVMPDQRVIYYYAAAQ 1214
            |||||||||||||:||||.||:|||||||||||||||::|||||||||||||||:||:|||||||
Mouse  1156 QGEISHPDGKVEKIYKNGRRVVLFPNGTRKEVSADGKSVTVTFFNGDVKQVMPDERVVYYYAAAQ 1220

Human  1215 TTHTTYPEGLEVLHFSSGQIEKHYPDGRKEITFPDQTVKNLFPDGQEESIFPDGTIVRVQRDGNK 1279
            |||||||||||||||||||||||:|||||||||||||:|.||.||||||||||||||||||||||
Mouse  1221 TTHTTYPEGLEVLHFSSGQIEKHFPDGRKEITFPDQTIKTLFADGQEESIFPDGTIVRVQRDGNK 1285

Human  1280 LIEFNNGQRELHTAQFKRREYPDGTVKTVYANGHQETKYRSGRIRVKDKEGNVLMDTEL 1338
            :||||||||||||||||||||||||||||||||||||||.|||:|||||:||||||||:
Mouse  1286 IIEFNNGQRELHTAQFKRREYPDGTVKTVYANGHQETKYTSGRVRVKDKDGNVLMDTEM 1344

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CPAP	NP_060921.3	Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	190..211		16/20 (80%)
		Alpha/beta-tubulin binding. /evidence=ECO:0000269\|PubMed:19131341	319..394		62/74 (84%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	386..414		22/27 (81%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	436..479		26/42 (62%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	521..551		17/29 (59%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	611..789		109/182 (60%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	845..865		10/19 (53%)
		SMC_N	<886..1148	CDD:481474	212/275 (77%)
		Interaction with STIL. /evidence=ECO:0000269\|PubMed:22020124, ECO:0000269\|PubMed:25385835	895..1338		378/456 (83%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	1096..1153		40/57 (70%)
		Tcp10_C	1152..1180	CDD:462118	24/27 (89%)
		Tcp10_C	1225..1253	CDD:462118	26/27 (96%)
		Tcp10_C	1261..1289	CDD:462118	26/27 (96%)
		Tcp10_C	1296..1325	CDD:462118	26/28 (93%)
Cpap	NP_001014996.2	Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	67..123		28/56 (50%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	187..225		24/46 (52%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	257..300		22/42 (52%)
		Alpha/beta-tubulin binding. /evidence=ECO:0000250\|UniProtKB:Q9HC77	307..382		62/74 (84%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	347..407		48/59 (81%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	425..470		28/44 (64%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	600..626		14/25 (56%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	672..735		45/63 (71%)
		Interaction with STIL. /evidence=ECO:0000250\|UniProtKB:Q9HC77	887..1344		378/456 (83%)
		COG4913	<901..>1046	CDD:443941	130/144 (90%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	1105..1133		21/27 (78%)
		Tcp10_C	1158..1186	CDD:462118	24/27 (89%)
		Tcp10_C	1231..1259	CDD:462118	26/27 (96%)
		Tcp10_C	1267..1295	CDD:462118	26/27 (96%)
		Tcp10_C	1302..1331	CDD:462118	26/28 (93%)

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DRSC/TRiP Functional Genomics Resources

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment CPAP and Cpap

DIOPT Version :10

Known Domains:

Indicated by green bases in alignment.