DRSC/TRiP Functional Genomics Resources

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Protein Alignment CPAP and Y73F8A.20

DIOPT Version :10

Sequence 1:NP_060921.3 Gene:CPAP / 55835 HGNCID:17272 Length:1338 Species:Homo sapiens
Sequence 2:NP_502855.1 Gene:Y73F8A.20 / 178430 WormBaseID:WBGene00013526 Length:541 Species:Caenorhabditis elegans


Alignment Length:565 Identity:109/565 - (19%)
Similarity:178/565 - (31%) Gaps:189/565 - (33%)


- Green bases have known domain annotations that are detailed below.


Human    77 EQKLESNNPYKPQSDKSE-----THTAFPCIKKGPQVAACHS-APGHQEENKNDFIPDLASEFKE 135
            :|..||:|..:..|....     .:|..|...:.||....:| ||.....    .:..||||...
 Worm    34 QQSTESSNSSEGDSPAIRWTTACLNTTCPIFSRSPQFNMIYSPAPSLMMY----VVVTLASEHAM 94

Human   136 GAYKDPLF----KKLEQLKEVQQKKQEQLKRQQLEQLQR-LMEEQEKLLTMVSGQCTLPGLSLLP 195
            ......||    |.:|:::|:.||..|.....|.....| |::||:  .|.||.:..:....:..
 Worm    95 TQTLQRLFGLTDKDMEEIREMSQKLSELGAPHQFYCFIRFLVDEQQ--TTTVSRELMIRSNDVAT 157

Human   196 DDQSQKHRSPG------NTTTGERATCCFPSYVYPDPTQEETYPSNILSHEQSNFCRTAHGDFVL 254
            .......| |.      ||.|....:...|:          .:.:|  .:..:....|.||:   
 Worm   158 QQVFSSIR-PSRVIKFLNTLTFHPVSVSRPA----------LFTTN--GYASAGLNATWHGE--- 206

Human   255 TSKRASPNLFS-----------------------------EAQYQEAPVEKN------------- 277
             :|:|..|.|:                             |..:...|...|             
 Worm   207 -AKKAGLNRFACTFHRKKFEEFFEIRTTYRRVLMDHFEVIELPFTFGPSSTNFGSLLILRPHFIG 270

Human   278 NLKEENRNHPTG------------ESILCWEKVTEQIQEAND----KNLQKHDDSSEVANIEERP 326
            ||...||...||            :.||....:..|...::.    |||.:|....::...::.|
 Worm   271 NLPYSNRQLTTGALSKMLDTLYSSDWILDGHLLIPQFSASSCQDLWKNLMRHGVQPDLGQSQKAP 335

Human   327 IKAAI--------------------GERKQ-----TFEDYLEEQIQLEEQELKQKQLKEAEGP-- 364
            ..|::                    ||:.|     ||.|.:.....||:.:....::   :.|  
 Worm   336 PMASLWHWASLKVGSSGISANVKKNGEKSQTTLHKTFHDRISTDSLLEKHKSYSGRI---DSPFS 397

Human   365 -------LPI---------KAKPKQPFLKRGEGLAR----FTNAKSKFQKGKESKLVTNQSTSED 409
                   :||         ..|..|.|:...|.:..    .|..:...:..::.:|:.....||:
 Worm   398 YIVMVHGIPIFTGSYFGSPPPKSSQVFINAPERIRHRRTIITKKRRNTKITRKQRLLRKVRKSEE 462

Human   410 QPLFKMDRQQLQRKTALKNKELCADNPILKKDSKARTKSGSVTLSQKPKMLKCSNRKSLSPSGLK 474
            :...| ||:: .:|..:||..       |||..|:.:.|.|...::      .|:.||.|.|   
 Worm   463 KEKEK-DRKR-AKKALIKNSN-------LKKKRKSNSSSSSNGTTE------TSSTKSSSTS--- 509

Human   475 IQTGKKCDGQFRDQIKFENKVTSNNKENVTECPKPCDTGCTGWNK 519
                              .||....||.|.|..|     .:||.:
 Worm   510 ------------------TKVVDVPKEKVIEKSK-----SSGWRR 531

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
CPAPNP_060921.3 Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 190..211 4/26 (15%)
Alpha/beta-tubulin binding. /evidence=ECO:0000269|PubMed:19131341 319..394 18/121 (15%)
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 386..414 4/27 (15%)
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 436..479 11/42 (26%)
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 521..551
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 611..789
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 845..865
SMC_N <886..1148 CDD:481474
Interaction with STIL. /evidence=ECO:0000269|PubMed:22020124, ECO:0000269|PubMed:25385835 895..1338
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 1096..1153
Tcp10_C 1152..1180 CDD:462118
Tcp10_C 1225..1253 CDD:462118
Tcp10_C 1261..1289 CDD:462118
Tcp10_C 1296..1325 CDD:462118
Y73F8A.20NP_502855.1 None
Blue background indicates that the domain is not in the aligned region.

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