DRSC/TRiP Functional Genomics Resources

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Protein Alignment CPAP and sas-4

DIOPT Version :10

Sequence 1:NP_060921.3 Gene:CPAP / 55835 HGNCID:17272 Length:1338 Species:Homo sapiens
Sequence 2:NP_498828.2 Gene:sas-4 / 176172 WormBaseID:WBGene00004726 Length:808 Species:Caenorhabditis elegans


Alignment Length:1030 Identity:193/1030 - (18%)
Similarity:327/1030 - (31%) Gaps:397/1030 - (38%)


- Green bases have known domain annotations that are detailed below.


Human   361 AEGPLPIKAKPKQPFLKRGEGLARF---TNAKSKFQKGKESKLVTNQSTSEDQPLFKMDRQQLQR 422
            |:|    :.||.:|||::|:|.|||   .|.|:.......|:|.:..|.|.:.|.|.:       
 Worm     9 ADG----EQKPSRPFLRKGQGTARFRMPRNNKTSAGAPPTSELSSASSPSINVPRFSL------- 62

Human   423 KTALKNKELCADNPILKKDSKARTKSGSVTLSQKPKMLKCSNRKSLSPSGLKIQTGKKCDGQFRD 487
            ..||.|.....|:.|..:|......:.|:.:.|              ||                
 Worm    63 SNALPNSARTVDSGISNEDETRPPTTASLPMDQ--------------PS---------------- 97

Human   488 QIKFENKVTSNNKENVTECPKPCDTGCTGWNKTQGKDRLPLSTGPASRLAAKSPIRETMKESESS 552
                                                    ||:.|.:||   :|.....:|...|
 Worm    98 ----------------------------------------LSSSPENRL---NPAPSVAEEHGHS 119

Human   553 LDVSLQKKLETWEREKEKENLELDEFLFLEQAADEISFSSNSSFVLKILERDQQICKGHRMSSTP 617
                       .:..:|:|:.:.||            .|:..|||                    
 Worm   120 -----------GQHAEEEEDNDTDE------------VSAMPSFV-------------------- 141

Human   618 VKAVPQKTNPADPISHCNRSEDLDHTA---REKESECEVAPKQLHSLSSADELREQPCKIRKAVQ 679
                     |.:|.:..|...:|...|   :...:|.:...:::.|:.||..:............
 Worm   142 ---------PDEPSTLVNSDHELSDDALKYKNAAAEFKAFERRMDSMRSASTITTSLATPSSCAP 197

Human   680 KSTSENQTEWN-ARDDEGV-PNSDSSTDSEEQLDVTIKPSTEDRERGISSREDSPQVCDDKGPFK 742
            .::||..|... ..:|.|| ||:.:...|.::|.            |||.  ::||.    .|..
 Worm   198 SNSSEPPTRSTPIMNDLGVGPNNHNWPSSMQELS------------GISL--ETPQA----RPLG 244

Human   743 DTRTQEDKRRDVDLDLSDKDYSSDESIMESIKHKVSEPSRSSSLSLSKMDFDDERTWTDLEENLC 807
            ..|..:..|.:                              :...:|.:...:..|.|       
 Worm   245 SNRINQLVRSE------------------------------AQTGISLLQHHERPTVT------- 272

Human   808 NHDVVLGNESTYGTPQTCYPNNEIGILDKTIKRKIAPVKRGEDLSKSRRSRSPPTSELMMKFFPS 872
                                               ||::|.:.::.||::               
 Worm   273 -----------------------------------APLRRNDMMNSSRQN--------------- 287

Human   873 LKPKPKSDSHLGNELKLNISQDQP---PGDNARSQVLREKIIELETEIEKFKAENASL----AKL 930
                 ..:.::.:|.:.....|||   ||    |.:.|:|   ||.||.:.:..|..|    |.|
 Worm   288 -----PQNGNVQDENRPEHVYDQPIHVPG----SSLDRQK---LEIEIRRHRNLNIQLRDTIAHL 340

Human   931 RIERESA------LEKLRKEIADFEQQKAKELARIEEFKKEEMRKLQKERKVFEKYTTAARTFPD 989
            ....||.      ||:...|:.:|:    |||  ||||||.:....::..|.|||.         
 Worm   341 DYAEESVHTTKRQLEEKISEVNNFK----KEL--IEEFKKCKKGVEEEFEKKFEKI--------- 390

Human   990 KKEREEI-QTLKQQIADLREDLK-------RKETKWSSTHSRLRSQIQMLVRENTDLREEIKVM- 1045
            |::.:|: :.||:...||..|.|       .:..:::.|.:.||.:::....:|...|::|:|. 
 Worm   391 KEDYDELYEKLKRDQRDLERDQKILKKGTGERNKEFTETIATLRDKLRASETKNAQYRQDIRVRD 455

Human  1046 ERFRLDAWKRAEAIE----------SSLE-VEKKDKLANTSVRFQNSQISSGTQVEKYKKNYLPM 1099
            |:.:    |:.|.||          |:|: :||:.|...|.....:.:.....:|...:|...|:
 Worm   456 EKLK----KKDEEIEKLQKDGNRLKSTLQTLEKRVKQLRTEKERDDKEKEMFAKVAMNRKTSNPV 516

Human  1100 QGNPPRRSKSAPPRDLGNLDKGQAASP--------REPLEPLNFPDPEYKEEEEDQDIQG----- 1151
               ||..::|.|   :.....|.:..|        |:|..........:.:|..:|.::.     
 Worm   517 ---PPVLNQSVP---ISITSNGPSRHPSSSSLTTFRKPSTSNRERGVSWADEPNEQSLEAVPQEF 575

Human  1152 ---EISHPDGKVEK--VYKNGCRVILFPNGTRKEVSADGKTITVTFFNGDVKQVMPDQRV-IYYY 1210
               .:....||..|  :|::..      ..|.|........:...:.|||::.|.....| ||..
 Worm   576 LMMPVKEMPGKFGKCTIYRDSL------GETSKVTDTIANGLLFEYSNGDLRWVNRQNAVNIYIS 634

Human  1211 AAAQTTHTTYPE-GLEVLHFSSGQIEKHYPDGRKEITFPDQTVKNLFPDGQEESIFPDGTIVRVQ 1274
            |..:|.....|. .:.::|                 ||..|                    |.|.
 Worm   635 AVDKTVRIDLPTYNISIIH-----------------TFQRQ--------------------VEVL 662

Human  1275 RDGNKLIEFNNGQRELHTAQFKRREYPDGTVKTVYANGHQETKY--RSGRIRVKD 1327
            |.||.:...:..:||:.|             ..:|.||..:|:.  |.||...||
 Worm   663 RPGNNITLISIKRREVRT-------------DLIYQNGMYKTEIFNRDGRYVTKD 704

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
CPAPNP_060921.3 Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 190..211
Alpha/beta-tubulin binding. /evidence=ECO:0000269|PubMed:19131341 319..394 14/35 (40%)
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 386..414 7/27 (26%)
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 436..479 6/42 (14%)
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 521..551 7/29 (24%)
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 611..789 27/182 (15%)
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 845..865 3/19 (16%)
SMC_N <886..1148 CDD:481474 74/302 (25%)
Interaction with STIL. /evidence=ECO:0000269|PubMed:22020124, ECO:0000269|PubMed:25385835 895..1338 110/488 (23%)
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 1096..1153 11/72 (15%)
Tcp10_C 1152..1180 CDD:462118 5/29 (17%)
Tcp10_C 1225..1253 CDD:462118 4/27 (15%)
Tcp10_C 1261..1289 CDD:462118 5/27 (19%)
Tcp10_C 1296..1325 CDD:462118 7/30 (23%)
sas-4NP_498828.2 Mplasa_alph_rch <315..505 CDD:275316 55/211 (26%)
HSD3 454..>558 CDD:464584 22/113 (19%)
Blue background indicates that the domain is not in the aligned region.

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