Protein Alignment CPAP and tcp10l2

DIOPT Version :10

• Sequence 1: NP_060921.3
• Gene: CPAP / 55835
• HGNCID: 17272
• Length: 1338
• Species: Homo sapiens
• Sequence 2: XP_012819173.2
• Gene: tcp10l2 / 100493055
• XenbaseID: XB-GENE-29099683
• Length: 1280
• Species: Xenopus tropicalis
• Alignment Length: 1520
• Identity: 418/1520 - (27%)
• Similarity: 648/1520 - (42%)
• Gaps: 466/1520 - (30%)

Human    35 FPILEADKEKRAAVDISTSFPIKGTHFSDSFSFINEEDSLLEEQKLESNNPYKPQSDKSETHTAF 99
            ||.|:.:..||....:..::  |.|....|..|.:.|.:..:......||    .||.|...|.
 Frog     6 FPELQTENSKRLPEHLLANY--KNTIHEHSPYFYSLEKNQGKNNDFADNN----FSDLSAILTN- 63

Human   100 PCIKKGPQVAACHSAPGHQEENKNDFIPDLASEFKEGAYKDPLFKKLEQLKEVQQKKQEQLKRQQ 164
               |.|.|    ..:|...:..:|.::..|.::.::..:..|        |:....:|:||.:||
 Frog    64 ---KIGKQ----FGSPPSIDTKENVYLSPLVTQNQDNRFYMP--------KQQNMTQQDQLMKQQ 113

Human   165 LEQLQRLMEEQEKLLTMVSGQCTLPGLSLLPDDQSQKHRSPGNTTTGERATCCFPSYVYPDPTQE 229
            :||||.|::||:||:.::.     |||:..|     |..||        .....|::|...|..|
 Frog   114 MEQLQILIKEQQKLINLIH-----PGLNFPP-----KLTSP--------LVPLMPNHVPKHPIGE 160

Human   230 ETYPSN---ILSHEQS-------NFCRTAHGDFVLTSKRASPN--LFSEAQYQEAPVEKNNLKEE 282
            |...:|   :|:.|.|       ......|.||::.|..||.:  :.:||......|||...:|.
 Frog   161 EMSANNSVKLLNQECSQTGSVLEQLVEENHRDFMMISDMASSSTQISAEASKTLYLVEKEKNEEP 225

Human   283 NRNHPTGESILCWEKVTEQIQEANDKNLQKHDDSSEVANIEERPIKAAIGERKQTFEDYLEEQIQ 347
            :...|                      |.......:..|.||||::..||.:::|||:::|||::
 Frog   226 STQTP----------------------LSPFGIRLKTKNHEERPLRPGIGVKQKTFEEFVEEQLK 268

Human   348 LEEQELKQKQLKEAEGPLPIKAKPKQPFLKRGEGLARFTNAKSKFQKGKESKLVTNQSTSEDQPL 412
            .:.:..::||  ..|.....||..::.|||||||:.||........|.:....:.|.|.||
 Frog   269 ADSEFAQKKQ--STESTFERKASFRKSFLKRGEGITRFEKKPINMAKEERKHSLPNVSRSE---- 327

Human   413 FKMDRQQLQRKTALKNKELCADNPILKKDSKARTKSGSVTLSQKPKMLKCSNRKSLSPSGLKIQT 477
             ..|.:......:: :.|:.:.|  |.|:.:|..::.::|||..|......:....:..|
 Frog   328 -SFDSKHRNSLPSI-HGEVKSCN--LSKEKQASEENTNITLSDIPGTSDIMHSLQRNDKG----- 383

Human   478 GKKC---DGQF-RDQIKFENKVTSNNKENVTECPKPCDTGCTGWNKTQGKDRLPLS---TGPASR 535
              ||   |.:| .|.::...:|:|..:...:          :.:|.|..|....||   |..|.:
 Frog   384 --KCLTEDQEFSHDTLQQHTRVSSEMELQYS----------SYYNPTLSKTETALSLHETNNAHK 436

Human   536 LA-AKSPIRETMKESESSLDVSLQKKLETWEREK--EKENLELDEFLFLEQAADEI--SFSSNSS 595
            :: |..|:   ..||.::.:|..::| |..|.:|  .|:|..|...|.||...|.:  :.|.::|
 Frog   437 ISIAAQPV---SPESVANHEVIKEEK-EPEENKKLNSKKNSTLHNDLSLELFKDTVLGTISEHNS 497

Human   596 FVLKILERDQQICKGHRMSS---TPVKAVPQKTNPADPISHCNRSEDLDHTAREKESECEVAPKQ 657
                        |..:...|   |..|.:..|..||||:.                   ::..:|
 Frog   498 ------------CSAYTTDSSVKTGFKKLNDKIVPADPLG-------------------DIMEEQ 531

Human   658 LHSLSSADELREQPCKIRKAVQKSTSENQTEWNARDDEGVPNSDSSTDSEEQLDVTIKPSTEDRE 722
            ..|:.:....|.:|.                             |.|||.|
 Frog   532 KFSVGTVQLKRVEPL-----------------------------SETDSVE-------------- 553

Human   723 RGISSREDSPQVCDDKGPFKDTRT----QEDKRRDVDLDLSDKDYSSDESIMESIKHKVSEPSRS 783
               |:.:|.|     |.|.....|    |:..:.|..|||||.||:|||...|..| |:..|
 Frog   554 ---SNSDDDP-----KSPCYKLITHDIPQKLNQGDCHLDLSDPDYASDEPSGEEDK-KLHLP--- 606

Human   784 SSLSLSKMDFDDERTWTDLEENLCNHDVVLGNESTYGTPQTCYP------NNEIGILDKTIKRKI 842
                               ::|:.||.  ..:||:.|: :.|..      |.......|...|::
 Frog   607 -------------------QKNMLNHQ--HPSESSSGS-EHCKETFRRRGNKAFSSFRKPSFRQL 649

Human   843 APVKRGEDLSK---------SRRSRSPPTSELMMKFFPSLKPK---PK--------SDSHLGNEL 887
            ..|::.::|:|         |..:..|.|.:|:...||..|.|   |:        |:||:.|.|
 Frog   650 RMVRQEKELNKKECDDSTKQSEPTFQPSTCDLVANLFPVFKMKADIPECVAPLQKTSESHIDNPL 714

Human   888 KLNISQDQPPGDNARSQVLREKIIELETEIEKFKAENASLAKLRIERESALEKLRKEIADFEQQK 952
                                                   |.|::.|:|.|:..||::|..||:.|
 Frog   715 ---------------------------------------LTKMKEEQEKAMAFLRQQIEHFEKVK 740

Human   953 AKELARIEEFKKEEMRKLQKERKVFEKYTTAARTFPDKKEREEIQTLKQQIADLREDLKRKETKW 1017
            |:||.::||||:|||:|||||::..||....|::..:.::.||||.||.||::|:.:..|.|::|
 Frog   741 AEELKKMEEFKREEMKKLQKEKEDLEKQAALAKSIKESEQNEEIQMLKLQISELQGEFHRHESRW 805

Human  1018 SSTHSRLRSQIQMLVRENTDLREEIKV-------MERFRLDAWKRAEAI---------------- 1059
            |:|.::|::|::.|.|||.:||:|::.       |:.::.::.. ::||
 Frog   806 STTENQLKTQVETLTRENQELRKELRAADNQFLEMQNYKSESLV-SQAIMRGTSSSMADQRMGRN 869

Human  1060 ----ESSLEVEKKD----------------KLAN------------------------------- 1073
                .||..||:|.                |:.|
 Frog   870 ERKSRSSTPVERKTLYDLSYGKQPLPENSAKVNNLIERHDIIKRTGTNGDASSGSFQSRSGTPTG 934

Human  1074 --TSVR-------------------------------FQNSQISSGTQVEKYKKNYLPMQGNPP- 1104
              |.||                               |:.|:||  ||::....:|.....:.|
 Frog   935 RKTPVRSRLTPFEPDKVTVVSAVSHRKSPIPASHLSVFKESKIS--TQMKGRSSSYSGSSDDAPV 997

Human  1105 -----------------RRSKSAPPRDLGNLDKGQ------------------AASPREPLEPLN 1134
                             .|.:|..|    |:.|.|                  :.:|.....|::
 Frog   998 SIIKNQELLHSSQSRNLERQESETP----NIRKMQVQQSWEKQGVNTNKTRKRSVTPNGRKTPVD 1058

Human  1135 FPD-PEYK------------------EEEEDQDIQGEISHPDGKVEKVYKNGCRVILFPNGTRKE 1180
            :.. .|.|                  :..||:.||.|..:||||||::..:|..||.|.|||:||
 Frog  1059 YTQCSEVKSSKPRSILSRKSSIHVGNKSSEDESIQEETQYPDGKVEQLLSDGRTVISFSNGTKKE 1123

Human  1181 VSADGKTITVTFFNGDVKQVMPDQRVIYYYAAAQTTHTTYPEGLEVLHFSSGQIEKHYPDGRKEI 1245
            :|||||..||.|||||||::||||.|:||||.||||||:||.|||||.|.:.|||||:|:|.|||
 Frog  1124 ISADGKATTVLFFNGDVKKMMPDQSVVYYYAEAQTTHTSYPSGLEVLQFPNKQIEKHHPEGVKEI 1188

Human  1246 TFPDQTVKNLFPDGQEESIFPDGTIVRVQRDGNKLIEFNNGQRELHTAQFKRREYPDGTVKTVYA 1310
            .|||:|:|.|:.||:||:.|||||||:::.:|.|.:.|:|||:|:||||||||||||||:||||:
 Frog  1189 IFPDRTIKLLYKDGREETTFPDGTIVKLETNGMKTVIFHNGQKEIHTAQFKRREYPDGTIKTVYS 1253

Human  1311 NGHQETKYRSGRIRVKDKEGNVLMD 1335
            ||.|||||.|||:|:||::||:::|
 Frog  1254 NGRQETKYSSGRVRIKDQQGNIILD 1278

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
CPAP	NP_060921.3	Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	190..211		6/20 (30%)
		Alpha/beta-tubulin binding. /evidence=ECO:0000269|PubMed:19131341	319..394		27/74 (36%)
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	386..414		5/27 (19%)
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	436..479		8/42 (19%)
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	521..551		9/33 (27%)
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	611..789		39/184 (21%)
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	845..865		6/28 (21%)
		SMC_N	<886..1148	CDD:481474	86/423 (20%)
		Interaction with STIL. /evidence=ECO:0000269|PubMed:22020124, ECO:0000269|PubMed:25385835	895..1338		208/603 (34%)
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	1096..1153		16/111 (14%)
		Tcp10_C	1152..1180	CDD:462118	14/27 (52%)
		Tcp10_C	1225..1253	CDD:462118	18/27 (67%)
		Tcp10_C	1261..1289	CDD:462118	15/27 (56%)
		Tcp10_C	1296..1325	CDD:462118	23/28 (82%)
tcp10l2	XP_012819173.2	Smc	<715..>836	CDD:440809	52/120 (43%)
		Tcp10_C	1094..1123	CDD:462118	14/28 (50%)
		Tcp10_C	1168..1196	CDD:462118	18/27 (67%)
		Tcp10_C	1186..1212	CDD:462118	16/25 (64%)
		Tcp10_C	1204..1233	CDD:462118	15/28 (54%)
		Tcp10_C	1239..1268	CDD:462118	23/28 (82%)