DRSC/TRiP Functional Genomics Resources

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Protein Alignment CAND1 and Cand1

DIOPT Version :10

Sequence 1:NP_060918.2 Gene:CAND1 / 55832 HGNCID:30688 Length:1230 Species:Homo sapiens
Sequence 2:NP_609389.1 Gene:Cand1 / 34403 FlyBaseID:FBgn0027568 Length:1248 Species:Drosophila melanogaster


Alignment Length:1256 Identity:737/1256 - (58%)
Similarity:941/1256 - (74%) Gaps:34/1256 - (2%)


- Green bases have known domain annotations that are detailed below.


Human     1 MASASYH-ISNLLEKMTSSDKDFRFMATNDLMTELQKDSIKLDDDSERKVVKMILKLLEDKNGEV 64
            |||..|| |:||||||||:|||||||||||||||||||||.|||:||:|||:|:|||||||||||
  Fly     1 MASHQYHQIANLLEKMTSTDKDFRFMATNDLMTELQKDSIILDDESEKKVVRMVLKLLEDKNGEV 65

Human    65 QNLAVKCLGPLVSKVKEYQVETIVDTLCTNMLSDKEQLRDISSIGLKTVIGELPPASSGSALAAN 129
            ||||||||||||:||||.|||||||:||.||:|:.|||||||||||||||.|||  .|.::||.|
  Fly    66 QNLAVKCLGPLVNKVKEIQVETIVDSLCANMMSNTEQLRDISSIGLKTVIAELP--QSSNSLAPN 128

Human   130 VCKKITGRLTSAIAKQEDVSVQLEALDIMADMLSRQGGLLVNFHPSILTCLLPQLTSPRLAVRKR 194
            ||::|||:|::||.| |||||:||:|||:||:|||.|..||.||.:||..|:|||.|.|.|||||
  Fly   129 VCQRITGKLSTAIEK-EDVSVKLESLDILADLLSRFGEFLVPFHSTILKALMPQLASSRQAVRKR 192

Human   195 TIIALGHLVMSCGNIVFVDLIEHLLSELSKNDSMSTTRTYIQCIAAISRQAGHRIGEYLEKIIPL 259
            ||:||..|::...:..:..:|:|||..|....:.:..||||||:|:|.||||||:..::::.:.|
  Fly   193 TIVALSFLLIQANSNAYNGVIDHLLDGLENPPNPAAIRTYIQCLASICRQAGHRLCNHIDRSMLL 257

Human   260 VVKFCNVDDDELREYCIQAFESFVRRCPKEVYPHVSTIINICLKYLTYDPNYNYDDEDEDE-NAM 323
            :.::...|||||||:|:||.|:||.|||..:.||:..|:.:||.|:||||||||:.:|.|. |||
  Fly   258 LSQYSQRDDDELREFCLQACEAFVMRCPDAINPHIPMILELCLNYITYDPNYNYETDDGDTGNAM 322

Human   324 DADGGDDDDQGSDDEYSDDDDMSWKVRRAAAKCLDAVVSTRHEMLPEFYKTVSPALISRFKEREE 388
            |.   :||:....:||||||||||||||||||||:.::|||.|::.:||:::|||||:|||||||
  Fly   323 DT---EDDEYVDSEEYSDDDDMSWKVRRAAAKCLEVLISTRQELVEDFYRSLSPALIARFKEREE 384

Human   389 NVKADVFHAYLSLLKQTRPVQSWLCDPDAMEQGETPLTMLQSQVPNIVKALHKQMKEKSVKTRQC 453
            |||:|:||||::|||.||.......|.|:|:|...|.::|..|:|.||||:...|:|||:||||.
  Fly   385 NVKSDIFHAYVALLKNTRLTDDVANDHDSMDQVSGPTSLLIEQLPLIVKAIQPLMREKSMKTRQD 449

Human   454 CFNMLTELVNVLPGALTQHIPVLVPGIIFSLNDKSSSSNLKIDALSCLYVILCNHSPQVFHPHVQ 518
            ||.:|.||:|.|||||..::..:||||.:|||||||:||:||::|..||.:|..|.|.|||||:.
  Fly   450 CFLLLRELLNSLPGALGPYLDSIVPGISYSLNDKSSTSNMKIESLGFLYSLLQGHPPHVFHPHIP 514

Human   519 ALVPPVVACVGDPFYKITSEALLVTQQLVKVIRPLD---QPSSFDATPYIKDLFTCTIKRLKAAD 580
            .|||.||..|.||||||.:|||||.||||||||||:   ..|.|||..::..:::||:::||..|
  Fly   515 LLVPLVVTSVFDPFYKIATEALLVLQQLVKVIRPLEPNAAKSDFDAPSFVGQVYSCTLQKLKVTD 579

Human   581 IDQEVKERAISCMGQIICNLGDNLGSDLPNTLQIFLERLKNEITRLTTVKALTLIAGSPLKIDLR 645
            :|||||||||:||||||.|:||.|.::|...|.||:||||||:|||::||||||||.|.|:|||.
  Fly   580 VDQEVKERAIACMGQIIANMGDMLQNELAVCLPIFMERLKNEVTRLSSVKALTLIAASSLRIDLT 644

Human   646 PVLGEGVPILASFLRKNQRALKLGTLSALDILIKNYSDSLTAAMIDAVLDELPPLISESDMHVSQ 710
            |:|.:.:|.|.:|||||.|||||.:|..::.::.|||.:..|.::...:.|:|||||:||:||:|
  Fly   645 PILHDVLPALGTFLRKNHRALKLHSLDLINKIVINYSSNFEANLLQTAIVEIPPLISDSDLHVAQ 709

Human   711 MAISFLTTLAKVYPSSLSKISGSILNELIGLVRSPLLQGGALSAMLDFFQALVVTGTNNLGYMDL 775
            .:::.|:|:|:..|.:|..|....|..::.|||||||||.||:..|:.|||||.|..:.|.|..|
  Fly   710 YSLTLLSTVARRQPQALVGIHEQFLRSVLILVRSPLLQGSALNCTLELFQALVQTQLSGLDYHSL 774

Human   776 LRMLTGPVY-------SQSTA-------LTHKQSYYSIAKCVAALTRACPKEGPAVVGQFIQDVK 826
            :..|..||.       |::||       ..|||:|:|.|||:||||:.||:....:..:.|.|::
  Fly   775 VSKLMAPVLGGNGDVKSRATAGAPSEVVQLHKQAYHSSAKCIAALTQQCPQVATPLATKLITDLQ 839

Human   827 NSRSTDSIRLLALLSLGEVGHHIDLSGQLELKSVILEAFSSPSEEVKSAASYALGSISVGNLPEY 891
            ....|:.|  ..||::||:|.|.|||....|...|:|.|.:.||:||:|||:|||::|||:|..|
  Fly   840 KRNDTEII--FCLLTIGEIGRHFDLSSIQVLPQTIIECFGATSEDVKAAASHALGAVSVGSLQTY 902

Human   892 LPFVLQEITSQPKRQYLLLHSLKEIISSASV-----VGLKPYVENIWALLLKHCECAEEGTRNVV 951
            ||.:|.||..||||||||||||||:|||.||     ..|.|.|.:||..|.|||||:|||:||||
  Fly   903 LPLILHEIEVQPKRQYLLLHSLKEVISSLSVSPSGLAQLLPSVPSIWDQLFKHCECSEEGSRNVV 967

Human   952 AECLGKLTLIDPETLLPRLKGYLISGSSYARSSVVTAVKFTISDHPQPIDPLLKNCIGDFLKTLE 1016
            |||||||.|::|:.|||:|:..|.|.|:..|:.||::|||||||.|||||.|||..||:||..|.
  Fly   968 AECLGKLVLVNPDELLPQLQQALRSESATMRTVVVSSVKFTISDQPQPIDVLLKQNIGEFLFALR 1032

Human  1017 DPDLNVRRVALVTFNSAAHNKPSLIRDLLDTVLPHLYNETKVRKELIREVEMGPFKHTVDDGLDI 1081
            ||:..|||||||.||||.||||||:||||.|:||.||:||||:.|||||||||||||||||||||
  Fly  1033 DPEPQVRRVALVAFNSAVHNKPSLVRDLLPTLLPWLYSETKVKSELIREVEMGPFKHTVDDGLDI 1097

Human  1082 RKAAFECMYTLLDSCLDRLDIFEFLNHVEDGLKDHYDIKMLTFLMLVRLSTLCPSAVLQRLDRLV 1146
            ||||||||||||:..|||:|:.:||:||:.||.|||||||||:||..||:.|||..||.|||:.:
  Fly  1098 RKAAFECMYTLLEQGLDRVDVMQFLDHVQAGLCDHYDIKMLTYLMTARLAILCPDKVLLRLDQFI 1162

Human  1147 EPLRATCTTKVKANSVKQEFEKQDELKRSAMRAVAALLTIPEAEKSPLMSEFQSQISSNPELAAI 1211
            :.||.|||.||||||||||:||||||||||:|||:||..||:|.|:..:.:|...|...|||..|
  Fly  1163 QQLRDTCTHKVKANSVKQEYEKQDELKRSALRAVSALSQIPKANKNQQLVDFLKSIKETPELNKI 1227

Human  1212 FESIQKDS--SSTNLESMDTS 1230
            ||.|||||  .|:::..||.|
  Fly  1228 FEYIQKDSITGSSDIIVMDQS 1248

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
CAND1NP_060918.2 HEAT 1 2..39 32/37 (86%)
HEAT repeat 11..32 CDD:293787 19/20 (95%)
HEAT 2 44..81 31/36 (86%)
HEAT repeat 53..74 CDD:293787 19/20 (95%)
HEAT 3 83..119 29/35 (83%)
HEAT repeat 87..119 CDD:293787 25/31 (81%)
HEAT repeat 129..164 CDD:293787 23/34 (68%)
HEAT 4 131..165 22/33 (67%)
HEAT_EZ 149..202 CDD:463906 34/52 (65%)
HEAT 5 171..208 20/36 (56%)
HEAT repeat 175..201 CDD:293787 17/25 (68%)
HEAT 6 210..247 16/36 (44%)
HEAT repeat 211..243 CDD:293787 13/31 (42%)
HEAT 7 248..282 13/33 (39%)
HEAT repeat 255..285 CDD:293787 14/29 (48%)
HEAT 8 289..366 45/77 (58%)
HEAT repeat 296..359 CDD:293787 40/63 (63%)
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 315..344 13/29 (45%)
HEAT 9 370..407 26/36 (72%)
HEAT repeat 372..397 CDD:293787 18/24 (75%)
HEAT 10 424..467 23/42 (55%)
HEAT 11 471..510 20/38 (53%)
HEAT 12 515..552 26/36 (72%)
HEAT 13 563..602 21/38 (55%)
HEAT repeat 573..600 CDD:293787 18/26 (69%)
HEAT 14 606..643 23/36 (64%)
HEAT repeat 610..638 CDD:293787 20/27 (74%)
HEAT 15 646..683 17/36 (47%)
HEAT repeat 647..676 CDD:293787 14/28 (50%)
HEAT 16 688..725 14/36 (39%)
HEAT repeat 690..719 CDD:293787 12/28 (43%)
HEAT 17 729..768 20/38 (53%)
HEAT 18 770..808 20/51 (39%)
HEAT 19 809..845 9/35 (26%)
HEAT repeat 817..847 CDD:293787 8/29 (28%)
HEAT 20 852..889 18/36 (50%)
HEAT repeat 856..886 CDD:293787 15/29 (52%)
HEAT 21 890..927 26/41 (63%)
HEAT repeat 894..918 CDD:293787 17/23 (74%)
HEAT 22 928..960 23/31 (74%)
HEAT repeat 929..958 CDD:293787 21/28 (75%)
HEAT 23 961..998 18/36 (50%)
HEAT 24 1002..1039 24/36 (67%)
TIP120 1040..1202 CDD:430111 113/161 (70%)
HEAT 25 1043..1097 45/53 (85%)
HEAT 26 1099..1133 21/33 (64%)
HEAT 27 1140..1189 35/48 (73%)
Cand1NP_609389.1 HEAT repeat 9..33 CDD:293787 21/23 (91%)
HEAT repeat 50..78 CDD:293787 25/27 (93%)
HEAT repeat 87..118 CDD:293787 24/30 (80%)
HEAT repeat 132..158 CDD:293787 17/26 (65%)
HEAT_EZ 147..200 CDD:463906 34/52 (65%)
HEAT repeat 171..200 CDD:293787 18/28 (64%)
HEAT repeat 212..242 CDD:293787 13/29 (45%)
HEAT repeat 253..277 CDD:293787 10/23 (43%)
HEAT repeat 513..538 CDD:293787 15/24 (63%)
HEAT repeat 545..569 CDD:293787 9/23 (39%)
HEAT repeat 609..636 CDD:293787 19/26 (73%)
HEAT repeat 647..676 CDD:293787 14/28 (50%)
HEAT repeat 982..1011 CDD:293787 15/28 (54%)
HEAT repeat 1022..1050 CDD:293787 17/27 (63%)
TIP120 1056..1210 CDD:430111 112/153 (73%)

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