DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment PRKCH and Pkcdelta

DIOPT Version :9

Sequence 1:	NP_006246.2	Gene:	PRKCH / 5583	HGNCID:	9403	Length:	683	Species:	Homo sapiens
Sequence 2:	NP_572797.3	Gene:	Pkcdelta / 32191	FlyBaseID:	FBgn0259680	Length:	1894	Species:	Drosophila melanogaster

Alignment Length:	417	Identity:	199/417 - (47%)
Similarity:	262/417 - (62%)	Gaps:	37/417 - (8%)

- Green bases have known domain annotations that are detailed below.

Human   296 GVNAVELAKTLAGMGLQPG-NISPTSKLVSRSTLRRQGKESSKEGNGIGVNSSNRL--------- 350
            |.||..|:...||.|...| :.|.:..::..||.   ..:|..|| |...:|..::
  Fly  1481 GSNAGTLSVPSAGSGSGGGASTSSSPSIIRMSTC---SNDSGFEG-GTAPSSPKKMLETSYTYSQ 1541

Human   351 --------------------GIDNFEFIRVLGKGSFGKVMLARVKETGDLYAVKVLKKDVILQDD 395
                                .:|:|.|:.||||||||||:||.:::|...||:|.|||||:|:||
  Fly  1542 FQKSGRFTAPATVIPRFKNYSVDDFHFLAVLGKGSFGKVLLAELRDTTYYYAIKCLKKDVVLEDD 1606

Human   396 DVECTMTEKRILSLARNHPFLTQLFCCFQTPDRLFFVMEFVNGGDLMFHIQKSRRFDEARARFYA 460
            ||:.|:.|:::|:|...||:|..|||.|||...||||||::||||||||||:|.||.|.|||||.
  Fly  1607 DVDSTLIERKVLALGTKHPYLCHLFCTFQTESHLFFVMEYLNGGDLMFHIQESGRFSEERARFYG 1671

Human   461 AEIISALMFLHDKGIIYRDLKLDNVLLDHEGHCKLADFGMCKEGICNGVTTATFCGTPDYIAPEI 525
            |||||.|.|||.||||||||||||||||:|||.::|||||||..|....|..:|||||||:||||
  Fly  1672 AEIISGLKFLHKKGIIYRDLKLDNVLLDYEGHVRIADFGMCKLQIYLDKTADSFCGTPDYMAPEI 1736

Human   526 LQEMLYGPAVDWWAMGVLLYEMLCGHAPFEAENEDDLFEAILNDEVVYPTWLHEDATGILKSFMT 590
            ::...|...||||:.||||||||.|.:||...:||:||.:|.|:...:|.::..:||||||..:.
  Fly  1737 IKGEKYNQNVDWWSFGVLLYEMLIGQSPFSGCDEDELFWSICNEIPWFPVYISAEATGILKGLLE 1801

Human   591 KNPTMRLGS-LTQGGEHAILRHPFFKEIDWAQLNHRQIEPPFRPRIKSREDVSNFDPDFIKEEPV 654
            |:.|.|:|| .:..|:  |..|.||:.|||..|..|||||||:|::|...|...||..|.:|...
  Fly  1802 KDYTKRIGSQYSPAGD--IADHIFFRPIDWGLLEKRQIEPPFKPQVKHPLDTQYFDRVFTRERVR 1864

Human   655 LTPIDEGHLPMINQDEFRNFSYVSPEL 681
            |||||:..|..::|.:|..|:|.:|.:
  Fly  1865 LTPIDKEILASMDQKQFHGFTYTNPHI 1891

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
PRKCH	NP_006246.2	C2_PKC_epsilon	8..140	CDD:175981
		C1_1	172..225	CDD:278556
		C1_1	246..298	CDD:278556	1/1 (100%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	320..342		5/21 (24%)
		S_TKc	355..614	CDD:214567	151/259 (58%)
		STKc_nPKC_eta	359..681	CDD:270742	180/322 (56%)
Pkcdelta	NP_572797.3	S_TKc	1566..1824	CDD:214567	151/259 (58%)
Pkcdelta	NP_572797.3	STKc_nPKC_theta_like	1570..1889	CDD:270744	179/320 (56%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C165149253
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D222529at2759
OrthoFinder	1	1.000	-	-		FOG0000117
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	1	1.030	-	avgDist	Average_Evolutionary_Distance	R891
SonicParanoid	1	1.000	-	-		X125
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	6	5.880