Protein Alignment PRKCG and aPKC

DIOPT Version :10

• Sequence 1: NP_001303258.1
• Gene: PRKCG / 5582
• HGNCID: 9402
• Length: 710
• Species: Homo sapiens
• Sequence 2: NP_001260984.1
• Gene: aPKC / 47594
• FlyBaseID: FBgn0261854
• Length: 958
• Species: Drosophila melanogaster
• Alignment Length: 687
• Identity: 236/687 - (34%)
• Similarity: 317/687 - (46%)
• Gaps: 221/687 - (32%)

Human     6 PGVGDSEGGPRPLFCRKGALRQKVVHEVKSHKFTARFFKQPTFCSHCTDFIWGIGKQGLQCQVCS 70
            ||: ..:|..|.:: |:||.|.:.::.|..|.|.|:.|.:..||::|.|.|||:|:||.:|..|.
  Fly   470 PGL-SCDGEDRSIY-RRGARRWRKLYRVNGHIFQAKRFNRRAFCAYCQDRIWGLGRQGFKCIQCK 532

Human    71 FVVHRRCHEFVTFECPGAGKGPQTDDPRNKHKFRLHSYSSPTFCDHCGSLLYGLVHQGMKCSCCE 135
            .:||::||:.|...|        ||.|....|.|....|.|
  Fly   533 LLVHKKCHKLVQKHC--------TDQPEPLVKERAEESSDP------------------------ 565

Human   136 MNVHRRCVRSVPSLCGVDHTERRGRLQLEIRAPTADEIHVTVGEARNLIPMDPNGLSDPYVKLKL 200
                      :|                                    :|:.|.    ||
  Fly   566 ----------IP------------------------------------VPLPPL----PY----- 575

Human   201 IPDPRNLTKQKTRTVKATLNPVWNETFVFNLKPGDVERRLSVEVWDWDRTSRNDFMGAMSFGVSE 265
                                                                    .|||.|.
  Fly   576 --------------------------------------------------------EAMSGGA-- 582

Human   266 LLKAPVDGWYKLLNQEEGEYYNVPVADADNCSLLQKFEACNYPLELYERVRMGPSSSPIPSPSPS 330
                                                 |||    |.::...       |.:| |.
  Fly   583 -------------------------------------EAC----ETHDHAH-------IVAP-PP 598

Human   331 PTDPKRCFFGASPG---RLHISDFSFLMVLGKGSFGKVMLAERRGSDELYAIKILKKDVIVQDDD 392
            |.||      ..||   :..::||..:.|:|:||:.||::.|.|.:..:||:|::||.::..|:|
  Fly   599 PEDP------LEPGTQRQYSLNDFELIRVIGRGSYAKVLMVELRRTRRIYAMKVIKKALVTDDED 657

Human   393 VDCTLVEKRVLALGGRGPGGRPHFLTQLHSTFQTPDRLYFVMEYVTGGDLMYHIQQLGKFKEPHA 457
            :|....||.|.......|     ||..|||.||||.||:||:|:|.|||||||:|:..:..|.||
  Fly   658 IDWVQTEKHVFETASNHP-----FLVGLHSCFQTPSRLFFVIEFVRGGDLMYHMQRQRRLPEEHA 717

Human   458 AFYAAEIAIGLFFLHNQGIIYRDLKLDNVMLDAEGHIKITDFGMCKENVFPGTTTRTFCGTPDYI 522
            .||||||::.|.|||.:||||||||||||:||.|||||:||:|||||.:.||.||.||||||:||
  Fly   718 RFYAAEISLALNFLHEKGIIYRDLKLDNVLLDHEGHIKLTDYGMCKEGIRPGDTTSTFCGTPNYI 782

Human   523 APEIIAYQPYGKSVDWWSFGVLLYEMLAGQPPF---------DGEDEEELFQAIMEQTVTYPKSL 578
            ||||:..:.||.|||||:.||||||||||:.||         |...|:.|||.|:|:|:..|:||
  Fly   783 APEILRGEDYGFSVDWWALGVLLYEMLAGRSPFDLAGASENPDQNTEDYLFQVILEKTIRIPRSL 847

Human   579 SREAVAICKGFLTKHPGKRLGSGPDGE-PTIRAHGFFRWIDWERLERLEIPPPFRPR-PCGRSGE 641
            |..|.::.||||.|:|..|||...:.. ..|.:|.||:.:|||.|||.::.|||:|| ...|...
  Fly   848 SVRAASVLKGFLNKNPADRLGCHRESAFMDIVSHPFFKNMDWELLERKQVTPPFKPRLDSDRDLA 912

Human   642 NFDKFFTRAAPALTPPDRLVLASIDQADFQGFTYVNP 678
            ||...||..|..|||.|..|:.:|||::|:||.||||
  Fly   913 NFPPEFTGEAVQLTPDDDHVIDNIDQSEFEGFEYVNP 949

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
PRKCG	NP_001303258.1	C1_cPKC_rpt1	34..91	CDD:410383	22/56 (39%)
		C1_cPKC_rpt2	101..154	CDD:410386	5/52 (10%)
		C2_PKC_alpha_gamma	158..289	CDD:175992	8/130 (6%)
		STKc_cPKC	354..677	CDD:270739	172/333 (52%)
aPKC	NP_001260984.1	C1_aPKC	496..550	CDD:410344	23/61 (38%)
		STKc_aPKC	620..947	CDD:270740	171/331 (52%)