Protein Alignment PRKCG and aurA

DIOPT Version :10

• Sequence 1: NP_001303258.1
• Gene: PRKCG / 5582
• HGNCID: 9402
• Length: 710
• Species: Homo sapiens
• Sequence 2: NP_476749.1
• Gene: aurA / 41446
• FlyBaseID: FBgn0000147
• Length: 411
• Species: Drosophila melanogaster
• Alignment Length: 288
• Identity: 90/288 - (31%)
• Similarity: 147/288 - (51%)
• Gaps: 27/288 - (9%)

Human   331 PTDPKRCFFGASPGRLHISDFSFLMVLGKGSFGKVMLAERRGSDELYAIKILKKDVIVQDDDVDC 395
            |..||:.:        .:::|....:||:|.||.|.||..:.|..:.|:|:|.|..|.:.:
  Fly   142 PQKPKKTW--------ELNNFDIGRLLGRGKFGNVYLAREKESQFVVALKVLFKRQIGESN---- 194

Human   396 TLVEKRV-LALGGRGPGGRPHFLTQLHSTFQTPDRLYFVMEYVTGGDLM--YHIQQLGKFKEPHA 457
              ||.:| ..:..:.....||.| :|::.|....|:|.::||...|.|.  ...|.:.:|.|..:
  Fly   195 --VEHQVRREIEIQSHLRHPHIL-RLYAYFHDDVRIYLILEYAPQGTLFNALQAQPMKRFDERQS 256

Human   458 AFYAAEIAIGLFFLHNQGIIYRDLKLDNVMLDAEGHIKITDFGMCKENVFPGTTTRTFCGTPDYI 522
            |.|...:...|.:||.:.||:||:|.:|::|..:|.:||.|||.....  |.:...|.|||.||:
  Fly   257 ATYIQALCSALLYLHERDIIHRDIKPENLLLGHKGVLKIADFGWSVHE--PNSMRMTLCGTVDYL 319

Human   523 APEIIAYQPYGKSVDWWSFGVLLYEMLAGQPPFDGEDEEELFQAIMEQTVTYPKSLSREAVAICK 587
            .||::..:|:.|:||.||.|||.:|:|.|..||..::.:|.::.|::.....|:.:|:.|..:..
  Fly   320 PPEMVQGKPHTKNVDLWSLGVLCFELLVGHAPFYSKNYDETYKKILKVDYKLPEHISKAASHLIS 384

Human   588 GFLTKHPGKRLGSGPDGE----PTIRAH 611
            ..|..:|..||   |..:    |.|.||
  Fly   385 KLLVLNPQHRL---PLDQVMVHPWILAH 409

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
PRKCG	NP_001303258.1	C1_cPKC_rpt1	34..91	CDD:410383
		C1_cPKC_rpt2	101..154	CDD:410386
		C2_PKC_alpha_gamma	158..289	CDD:175992
		STKc_cPKC	354..677	CDD:270739	86/265 (32%)
aurA	NP_476749.1	STKc_Aurora	153..407	CDD:270909	84/265 (32%)