Protein Alignment PRKCG and inaC

DIOPT Version :10

• Sequence 1: NP_001303258.1
• Gene: PRKCG / 5582
• HGNCID: 9402
• Length: 710
• Species: Homo sapiens
• Sequence 2: NP_476863.1
• Gene: inaC / 36897
• FlyBaseID: FBgn0004784
• Length: 700
• Species: Drosophila melanogaster
• Alignment Length: 687
• Identity: 344/687 - (50%)
• Similarity: 456/687 - (66%)
• Gaps: 28/687 - (4%)

Human     2 AGLGPGVGDSEGGPRPLF------CRKGALRQKVVHEVKSHKFTARFFKQPTFCSHCTDFIWGIG 60
            ||.|||......|...:.      .||||:::|.:..|..|:|..||||.||:|.||.|||||.|
  Fly    32 AGKGPGNLLEITGEANIVNYMKNRLRKGAMKRKGLEMVNGHRFGVRFFKNPTYCGHCKDFIWGFG 96

Human    61 KQGLQCQVCSFVVHRRCHEFVTFECPGAGKGPQTDDPRNKHKFRLHSYSSPTFCDHCGSLLYGLV 125
            |||.||:.|.|.:|::|.:||.|:|||.......|..:.||.:...:|::|||||.||.||:|:.
  Fly    97 KQGFQCEECRFNIHQKCCKFVVFKCPGKDTDFDADCAKVKHGWISTTYTTPTFCDECGLLLHGVA 161

Human   126 HQGMKCSCCEMNVHRRCVRSVPSLCGVDHTERRGRLQLEIRAPTADEIHVTVGEARNLIPMDPNG 190
            |||:||..|.:|||..|..:||.:||.|.:|.||:|.|.:.. ..:.:.|.:.||.||||||.||
  Fly   162 HQGVKCENCNLNVHHACQETVPPMCGADISEVRGKLLLYVEL-KGNNLKVDIKEAANLIPMDTNG 225

Human   191 LSDPYVKLKLIPDPRNLTKQKTRTVKATLNPVWNETFVFNLKPGDVERRLSVEVWDWDRTSRNDF 255
            .||||:.:::.||....||:||:|::..||||:||||.|.|:|.|.::||.:|||||||||||||
  Fly   226 FSDPYIAVQMHPDRSGRTKKKTKTIQKNLNPVFNETFTFELQPQDRDKRLLIEVWDWDRTSRNDF 290

Human   256 MGAMSFGVSELLKAPVDGWYKLLNQEEGEYYNVPVADADNCSLLQKFEACNYPLELYERVRMGPS 320
            ||:.||.:.||.|.|||||||.|:|.|||:||:|..||.| .:.:..:...:.....|:.||...
  Fly   291 MGSFSFSLEELQKEPVDGWYKFLSQVEGEHYNIPCVDAFN-DIARLRDEVRHDRRPNEKRRMDNK 354

Human   321 SSPIPSPSPSPTDPKRCFFGASPGRLHISDFSFLMVLGKGSFGKVMLAERRGSDELYAIKILKKD 385
            ..|   .:.|..|           .:..:||:|:.|:||||||||:||||||:|||||:|:|:||
  Fly   355 DMP---HNMSKRD-----------MIRAADFNFVKVIGKGSFGKVLLAERRGTDELYAVKVLRKD 405

Human   386 VIVQDDDVDCTLVEKRVLALGGRGPGGRPHFLTQLHSTFQTPDRLYFVMEYVTGGDLMYHIQQLG 450
            ||:|.||::..:.||::|||     .|||.||..:||.|||.|||:|||||..|||||||:||.|
  Fly   406 VIIQTDDMELPMNEKKILAL-----SGRPPFLVSMHSCFQTMDRLFFVMEYCKGGDLMYHMQQYG 465

Human   451 KFKEPHAAFYAAEIAIGLFFLHNQGIIYRDLKLDNVMLDAEGHIKITDFGMCKENVFPGTTTRTF 515
            :|||..|.|||.|:||.|||||.:.||||||||||::||.|||:|:.|||:.||.|....|||||
  Fly   466 RFKESVAIFYAVEVAIALFFLHERDIIYRDLKLDNILLDGEGHVKLVDFGLSKEGVTERQTTRTF 530

Human   516 CGTPDYIAPEIIAYQPYGKSVDWWSFGVLLYEMLAGQPPFDGEDEEELFQAIMEQTVTYPKSLSR 580
            ||||:|:||||::|.||..:.|||||||||:|.:|||.||:|:||..:|:.|.::...:||..|.
  Fly   531 CGTPNYMAPEIVSYDPYSIAADWWSFGVLLFEFMAGQAPFEGDDETTVFRNIKDKKAVFPKHFSV 595

Human   581 EAVAICKGFLTKHPGKRLGSGPDGEPTIRAHGFFRWIDWERLERLEIPPPFRPRPCGRSG-ENFD 644
            ||:.|...||||.|..|||:|......|..|.|||.:||::.|..|:.||.:|....|.. .|||
  Fly   596 EAMDIITSFLTKKPNNRLGAGRYARQEITTHPFFRNVDWDKAEACEMEPPIKPMIKHRKDISNFD 660

Human   645 KFFTRAAPALTPPDRLVLASIDQADFQGFTYVNPDFV 681
            ..||:....|||.|:|.:.::||.||.||:::||:|:
  Fly   661 DAFTKEKTDLTPTDKLFMMNLDQNDFIGFSFMNPEFI 697

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
PRKCG	NP_001303258.1	C1_cPKC_rpt1	34..91	CDD:410383	32/56 (57%)
		C1_cPKC_rpt2	101..154	CDD:410386	26/52 (50%)
		C2_PKC_alpha_gamma	158..289	CDD:175992	74/130 (57%)
		STKc_cPKC	354..677	CDD:270739	180/323 (56%)
inaC	NP_476863.1	C1_cPKC_nPKC_rpt1	71..123	CDD:410342	30/51 (59%)
		C1	137..190	CDD:412127	26/52 (50%)
		C2_PKC_alpha_gamma	194..324	CDD:175992	74/130 (57%)
		STKc_PKC	375..692	CDD:270722	180/321 (56%)