Protein Alignment PRKCG and Pka-C1

DIOPT Version :10

• Sequence 1: NP_001303258.1
• Gene: PRKCG / 5582
• HGNCID: 9402
• Length: 710
• Species: Homo sapiens
• Sequence 2: NP_476977.1
• Gene: Pka-C1 / 34284
• FlyBaseID: FBgn0000273
• Length: 353
• Species: Drosophila melanogaster
• Alignment Length: 302
• Identity: 118/302 - (39%)
• Similarity: 180/302 - (59%)
• Gaps: 14/302 - (4%)

Human   348 ISDFSFLMVLGKGSFGKVMLAERRGSDELYAIKILKKDVIVQDDDVDCTLVEKRVL-ALGGRGPG 411
            :.||..:..||.||||:||:.:.:.:.:.||:|||.|..:|:...|:.||.|||:| |:  :.|
  Fly    43 LDDFERIKTLGTGSFGRVMIVQHKPTKDYYAMKILDKQKVVKLKQVEHTLNEKRILQAI--QFP- 104

Human   412 GRPHFLTQLHSTFQTPDRLYFVMEYVTGGDLMYHIQQLGKFKEPHAAFYAAEIAIGLFFLHNQGI 476
                ||..|...|:....||.|:|||.||::..|::::|:|.|||:.||||:|.:...:||...:
  Fly   105 ----FLVSLRYHFKDNSNLYMVLEYVPGGEMFSHLRKVGRFSEPHSRFYAAQIVLAFEYLHYLDL 165

Human   477 IYRDLKLDNVMLDAEGHIKITDFGMCKENVFPGTTTRTFCGTPDYIAPEIIAYQPYGKSVDWWSF 541
            ||||||.:|:::|::|::|:||||..|.  ..|.|. |.||||:|:|||||..:.|.|:||||:.
  Fly   166 IYRDLKPENLLIDSQGYLKVTDFGFAKR--VKGRTW-TLCGTPEYLAPEIILSKGYNKAVDWWAL 227

Human   542 GVLLYEMLAGQPPFDGEDEEELFQAIMEQTVTYPKSLSREAVAICKGFLTKHPGKRLGSGPDGEP 606
            |||:|||.||.|||..:...::::.|:...|.:|.....:...:.:..|.....||.|:...|..
  Fly   228 GVLVYEMAAGYPPFFADQPIQIYEKIVSGKVRFPSHFGSDLKDLLRNLLQVDLTKRYGNLKAGVN 292

Human   607 TIRAHGFFRWIDWERLERLEIPPPFRPRPCGRSGE--NFDKF 646
            .|:...:|...||..:.:.:|..||.|| |...|:  |||.:
  Fly   293 DIKNQKWFASTDWIAIFQKKIEAPFIPR-CKGPGDTSNFDDY 333

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
PRKCG	NP_001303258.1	C1_cPKC_rpt1	34..91	CDD:410383
		C1_cPKC_rpt2	101..154	CDD:410386
		C2_PKC_alpha_gamma	158..289	CDD:175992
		STKc_cPKC	354..677	CDD:270739	116/296 (39%)
Pka-C1	NP_476977.1	STKc_PKA	44..333	CDD:271111	118/299 (39%)