Protein Alignment PRKCG and pck1

DIOPT Version :10

• Sequence 1: NP_001303258.1
• Gene: PRKCG / 5582
• HGNCID: 9402
• Length: 710
• Species: Homo sapiens
• Sequence 2: NP_593737.2
• Gene: pck1 / 2542293
• PomBaseID: SPAC17G8.14C
• Length: 988
• Species: Schizosaccharomyces pombe
• Alignment Length: 688
• Identity: 242/688 - (35%)
• Similarity: 337/688 - (48%)
• Gaps: 134/688 - (19%)

Human    21 RKGALRQK---VVHEVKSHKFTARFFKQPTFCSHCTD-FIWGIGKQGLQCQVCSFVVHRRCHEFV 81
            |:||:|||   ||.....|:|..|.|.|...|:.|.: |.:   ..||||:.||||.|::|...|
pombe   396 RQGAIRQKKEDVVASQVGHQFVQRQFYQIMRCAVCAELFSY---SPGLQCENCSFVCHKKCVTKV 457

Human    82 TFECPGAGKGPQTD----DPRNKHKFRLHSYSSPTFCDHCGSLLYGLVHQGMKCSCCEMNVHRRC 142
            ...|.......::|    ..|..|:|...:.....:|.|||..|........||..|.:..|.:|
pombe   458 LASCIAQSNSEKSDFGGLRYRIPHRFEPFNSLGAQWCAHCGFFLPLRRKDCFKCVECGITCHGQC 522

Human   143 VRSVPSLCGVDHTERRGRL-QLEI-RAPTADEIHVTVGEARNLIPMDPNGLSDPYVKLKLIPDPR 205
            ...:|..||:.:..:...| :||: :.|...|:              ||
pombe   523 AHLIPDYCGMSNDLKHQLLTELEVSKRPKKPEL--------------PN---------------- 557

Human   206 NLTKQKTRTVKATLNPVWNETFVFNLKPGDVERRLSVEVWDWDRTSRNDF--MGAMSFGVSELLK 268
              .:.||...|....|:                           :|:|.|  :..:|.|   ||.
pombe   558 --QENKTTNEKVYRKPL---------------------------SSQNTFDTLPTISQG---LLA 590

Human   269 APVDGWYKLLNQEEGEYYNVPVADADNCSLLQKFEACNYPLELYERVRMGPSSS-PIPS-----P 327
            |                 ..||....|.|.|.|..      |....:.:.|||| |.|:     |
pombe   591 A-----------------TQPVTSVLNTSPLPKTP------EKDRSLNVTPSSSTPTPASVLAPP 632

Human   328 SPS------------PTDPKRCFFGASPGRLHISDFSFLMVLGKGSFGKVMLAERRGSDELYAIK 380
            |.:            |..|:|    ....|:.:.||:||.|||||:||||||||.:.:.:.||||
pombe   633 SSASLSSSKDANRSVPESPRR----EKKNRVTLDDFTFLAVLGKGNFGKVMLAEYKVNKKFYAIK 693

Human   381 ILKKDVIVQDDDVDCTLVEKRVLALGGRGPGGRPH-FLTQLHSTFQTPDRLYFVMEYVTGGDLMY 444
            :|||:.|:::::::....||.|..:..:    ..| ||..|.::|||..|:||||||:.|||||.
pombe   694 VLKKEAILKNEELESLKTEKHVFEVANK----EKHPFLLNLFASFQTSTRVYFVMEYILGGDLMV 754

Human   445 HIQQLGKFKEPHAAFYAAEIAIGLFFLHNQGIIYRDLKLDNVMLDAEGHIKITDFGMCKENVFPG 509
            |||: .:|....|.||.||:.:.|.:.|..||.||||||||::|..:|||:|.|:|:||||:..|
pombe   755 HIQR-QQFSVKRARFYGAEVCLALKYFHENGIAYRDLKLDNILLCPDGHIRIADYGLCKENMLLG 818

Human   510 TTTRTFCGTPDYIAPEIIAYQPYGKSVDWWSFGVLLYEMLAGQPPFDGEDEEELFQAIMEQTVTY 574
            .||.||||||:::||||:..|.|.|.||||:||||:|:||.||.||.||||||:|.||:.....:
pombe   819 NTTSTFCGTPEFMAPEILLEQQYSKDVDWWAFGVLMYQMLLGQSPFKGEDEEEIFDAILSDEPLF 883

Human   575 PKSLSREAVAICKGFLTKHPGKRLGSGPDGEPTIRAHGFFRWIDWERLERLEIPPPFRP---RPC 636
            |.::..:||::.:|.||:.|.:||||||.....:.||.||..|.|:.|......|.::|   .|
pombe   884 PINMPADAVSLLRGLLTRDPNQRLGSGPKDANEVMAHPFFASIVWDDLYNKLYEPSYKPLINDP- 947

Human   637 GRSGENFDKFFTRAAPALTPPDRLVLASIDQADFQGFT 674
             |...|||:.||.|.|.|||.: .||....|..|:||:
pombe   948 -RDLNNFDEEFTSACPTLTPVN-TVLTRQQQECFRGFS 983

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
PRKCG	NP_001303258.1	C1_cPKC_rpt1	34..91	CDD:410383	20/57 (35%)
		C1_cPKC_rpt2	101..154	CDD:410386	15/52 (29%)
		C2_PKC_alpha_gamma	158..289	CDD:175992	19/134 (14%)
		STKc_cPKC	354..677	CDD:270739	156/325 (48%)
pck1	NP_593737.2	HR1_PKC-like_1_fungi	2..73	CDD:212011
		HR1	111..180	CDD:469609
		C2	212..316	CDD:472691
		C1_ScPKC1-like_rpt1	413..464	CDD:410372	20/53 (38%)
		C1_ScPKC1-like_rpt2	477..535	CDD:410373	16/57 (28%)
		STKc_PKC	668..983	CDD:270722	154/322 (48%)